AIMC Topic: Gene Expression Profiling

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Molecular modeling of C1-inhibitor as SARS-CoV-2 target identified from the immune signatures of multiple tissues: An integrated bioinformatics study.

Cell biochemistry and function Dec 14, 2022
The expeditious transmission of the severe acute respiratory coronavirus 2 (SARS-CoV-2), a strain of COVID-19, crumbled the global economic strength and caused a veritable collapse in health infrastructure. The molecular modeling of the novel coronav...
SARS-CoV-2 Gene Expression Profiling Machine Learning COVID-19 Immunity COVID-19 Drug Treatment Humans Complement C1 Inhibitor Protein Artificial Intelligence COVID-19 Vaccines Computational Biology
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Application of Deep Learning on Single-cell RNA Sequencing Data Analysis: A Review.

Genomics, proteomics & bioinformatics Dec 14, 2022
Single-cell RNA sequencing (scRNA-seq) has become a routinely used technique to quantify the gene expression profile of thousands of single cells simultaneously. Analysis of scRNA-seq data plays an important role in the study of cell states and pheno...
Cluster Analysis Single-Cell Analysis Sequence Analysis, RNA Humans Artificial Intelligence Gene Expression Profiling COVID-19 Deep Learning
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Deepgmd: A Graph-Neural-Network-Based Method to Detect Gene Regulator Module.

IEEE/ACM transactions on computational biology and bioinformatics Dec 8, 2022
Regulatory module mining methods divide genes into multiple gene subgroups and explore potential biological mechanisms from omics data. By transforming gene expression profile data into gene co-expression network, we transform the task of gene module...
Gene Expression Profiling Transcriptome Gene Regulatory Networks Neural Networks, Computer Algorithms
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Integrative transcriptome analysis of SARS-CoV-2 human-infected cells combined with deep learning algorithms identifies two potential cellular targets for the treatment of coronavirus disease.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] Nov 26, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) quickly spread worldwide, leading coronavirus disease 2019 (COVID-19) to hit pandemic level less than 4 months after the first official cases. Hence, the search for drugs and vaccines that ...
SARS-CoV-2 Molecular Docking Simulation Humans COVID-19 Gene Expression Profiling Deep Learning
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Graph deep learning for the characterization of tumour microenvironments from spatial protein profiles in tissue specimens.

Nature biomedical engineering Nov 10, 2022
Multiplexed immunofluorescence imaging allows the multidimensional molecular profiling of cellular environments at subcellular resolution. However, identifying and characterizing disease-relevant microenvironments from these rich datasets is challeng...
Humans Neural Networks, Computer Tumor Microenvironment Gene Expression Profiling Deep Learning
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A model-based constrained deep learning clustering approach for spatially resolved single-cell data.

Genome research Oct 5, 2022
Spatially resolved scRNA-seq (sp-scRNA-seq) technologies provide the potential to comprehensively profile gene expression patterns in tissue context. However, the development of computational methods lags behind the advances in these technologies, wh...
Deep Learning Single-Cell Analysis Sequence Analysis, RNA Cluster Analysis Gene Expression Profiling
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Integrative Histology-Genomic Analysis Predicts Hepatocellular Carcinoma Prognosis Using Deep Learning.

Genes Sep 30, 2022
Cancer prognosis analysis is of essential interest in clinical practice. In order to explore the prognostic power of computational histopathology and genomics, this paper constructs a multi-modality prognostic model for survival prediction. We collec...
Carcinoma, Hepatocellular Genomics Deep Learning Gene Expression Regulation, Neoplastic RNA, Messenger Liver Neoplasms Humans Prognosis Gene Expression Profiling
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Transforming L1000 profiles to RNA-seq-like profiles with deep learning.

BMC bioinformatics Sep 13, 2022
The L1000 technology, a cost-effective high-throughput transcriptomics technology, has been applied to profile a collection of human cell lines for their gene expression response to > 30,000 chemical and genetic perturbations. In total, there are cur...
Humans Deep Learning RNA-Seq Gene Expression Profiling Transcriptome
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A survey on gene expression data analysis using deep learning methods for cancer diagnosis.

Progress in biophysics and molecular biology Aug 19, 2022
Gene Expression Data is the biological data to extract meaningful hidden information from the gene dataset. This gene information is used for disease diagnosis especially in cancer treatment based on the variations in gene expression levels. DNA micr...
Neural Networks, Computer Deep Learning Data Analysis Neoplasms Gene Expression Gene Expression Profiling
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Gene Identification and Potential Drug Therapy for Drug-Resistant Melanoma with Bioinformatics and Deep Learning Technology.

Disease markers Jul 23, 2022
BACKGROUND: Melanomas are skin malignant tumors that arise from melanocytes which are primarily treated with surgery, chemotherapy, targeted therapy, immunotherapy, radiation therapy, etc. Targeted therapy is a promising approach to treating advanced...
Gene Expression Regulation, Neoplastic Gene Ontology Gene Expression Profiling Deep Learning Prognosis Humans Protein Interaction Maps Melanoma Technology Computational Biology
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