AIMC Topic: Genes, Essential
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A Machine Learning Approach for Predicting Essentiality of Metabolic Genes.
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2024
The identification of essential genes is a key challenge in systems and synthetic biology, particularly for engineering metabolic pathways that convert feedstocks into valuable products. Assessment of gene essentiality at a genome scale requires larg...
Machine learning approach to gene essentiality prediction: a review.
Briefings in bioinformatics
Sep 2, 2021
UNLABELLED: Essential genes are critical for the growth and survival of any organism. The machine learning approach complements the experimental methods to minimize the resources required for essentiality assays. Previous studies revealed the need to...
ICG: a wiki-driven knowledgebase of internal control genes for RT-qPCR normalization.
Nucleic acids research
Jan 4, 2018
Real-time quantitative PCR (RT-qPCR) has become a widely used method for accurate expression profiling of targeted mRNA and ncRNA. Selection of appropriate internal control genes for RT-qPCR normalization is an elementary prerequisite for reliable ex...
An integrative machine learning strategy for improved prediction of essential genes in Escherichia coli metabolism using flux-coupled features.
Molecular bioSystems
Jul 25, 2017
Prediction of essential genes helps to identify a minimal set of genes that are absolutely required for the appropriate functioning and survival of a cell. The available machine learning techniques for essential gene prediction have inherent problems...
Gene essentiality prediction based on fractal features and machine learning.
Molecular bioSystems
Feb 28, 2017
Essential genes are required for the viability of an organism. Accurate and rapid identification of new essential genes is of substantial theoretical interest to synthetic biology and has practical applications in biomedicine. Fractals provide facili...
An integrated machine-learning model to predict prokaryotic essential genes.
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2015
Essential genes are indispensable for the target organism's survival. Large-scale identification and characterization of essential genes has shown to be beneficial in both fundamental biology and medicine fields. Current existing genome-scale experim...
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