Briefings in bioinformatics
Jan 17, 2022
The innovation of biotechnologies has allowed the accumulation of omics data at an alarming rate, thus introducing the era of 'big data'. Extracting inherent valuable knowledge from various omics data remains a daunting problem in bioinformatics. Bet...
Briefings in bioinformatics
Jan 17, 2022
High-throughput next-generation sequencing now makes it possible to generate a vast amount of multi-omics data for various applications. These data have revolutionized biomedical research by providing a more comprehensive understanding of the biologi...
Nucleic acids research
Jan 7, 2022
The Human Disease Ontology (DO) (www.disease-ontology.org) database, has significantly expanded the disease content and enhanced our userbase and website since the DO's 2018 Nucleic Acids Research DATABASE issue paper. Conservatively, based on availa...
Journal of biosciences
Jan 1, 2022
An organism's genome contains many sequence regions that perform diverse functions. Examples of such regions include genes, promoters, enhancers, and binding sites for regulatory proteins and RNAs. One of biology's most important open problems is how...
Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Jan 1, 2022
We are constructing the "Percellome Database" containing many transcriptomes of mice exposed to a series of chemicals to elucidate the molecular mechanism of toxicity and to develop toxicity prediction technology. Acute toxicity of a chemical can be ...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2022
The dramatic convergence of molecular biology, genomics, proteomics, metabolomics, bioinformatics, and artificial intelligence has provided a substrate for deep understanding of the biological basis of health and disease. Systems biology is a holisti...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2022
Often likened to "the new electricity," artificial intelligence (AI) has broad and sweeping impact in many areas. Perhaps most exciting among these are in bioinformatics as AI allows for new and increasingly powerful ways of understanding genomics, p...
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Jan 1, 2022
As the last decade of human genomics research begins to bear the fruit of advancements in precision medicine, it is important to ensure that genomics' improvements in human health are distributed globally and equitably. An important step to ensuring ...
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
Dec 30, 2021
Clinical genomics mainly studies the clinical application of genomics in diagnosis,treatment decision,and prognosis prediction.Artificial intelligence enables the processing of complex and massive data in genomics which are difficult to be dealt with...
Blood
Nov 11, 2021
Although genomic alterations drive the pathogenesis of acute myeloid leukemia (AML), traditional classifications are largely based on morphology, and prototypic genetic founder lesions define only a small proportion of AML patients. The historical su...