AIMC Topic: Translocation, Genetic

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A multi-omic single-cell landscape reveals transcription and epigenetic regulatory features of t(8;21) AML.

Journal of translational medicine Jul 24, 2025
BACKGROUND: Comprehensive analysis of single-cell transcriptome and chromatin accessibility will contribute to interpret the heterogeneity of acute myeloid leukemia (AML). We hypothesize that integrating single-cell transcriptomic and chromatin acces...
Humans Transcription, Genetic Gene Expression Regulation, Leukemic Multiomics Epigenesis, Genetic Chromosomes, Human, Pair 8 Chromosomes, Human, Pair 21 Chromatin Translocation, Genetic Leukemia, Myeloid, Acute Male Middle Aged Single-Cell Analysis Reproducibility of Results Adult Female
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Artificial intelligence to detect MYC translocation in slides of diffuse large B-cell lymphoma.

Virchows Archiv : an international journal of pathology Sep 26, 2020
In patients with suspected lymphoma, the tissue biopsy provides lymphoma confirmation, classification, and prognostic factors, including genetic changes. We developed a deep learning algorithm to detect MYC rearrangement in scanned histological slide...
Biomarkers, Tumor Proto-Oncogene Proteins c-myc Predictive Value of Tests Lymphoma, Large B-Cell, Diffuse Deep Learning Immunohistochemistry Microscopy Translocation, Genetic Phenotype Genetic Predisposition to Disease Proof of Concept Study Antigens, CD20 Reproducibility of Results In Situ Hybridization, Fluorescence Staining and Labeling Humans Image Interpretation, Computer-Assisted
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Prediction of B/T Subtype and ETV6-RUNX1 Translocation in Pediatric Acute Lymphoblastic Leukemia by Deep Learning Analysis of Giemsa-Stained Whole Slide Images of Bone Marrow Aspirates.

Pediatric blood & cancer Aug 1, 2025
BACKGROUND: Accurate determination of B/T-cell lineage and the presence of the ETV6-RUNX1 translocation is critical for diagnosing acute lymphoblastic leukemia (ALL), as these factors influence treatment decisions and outcomes. However, these diagnos...
Precursor Cell Lymphoblastic Leukemia-Lymphoma Translocation, Genetic Bone Marrow ETS Translocation Variant 6 Protein Oncogene Proteins, Fusion Core Binding Factor Alpha 2 Subunit Deep Learning Adolescent Child, Preschool Child Male Infant Female Humans Prognosis
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Machine learning integrates genomic signatures for subclassification beyond primary and secondary acute myeloid leukemia.

Blood Nov 11, 2021
Although genomic alterations drive the pathogenesis of acute myeloid leukemia (AML), traditional classifications are largely based on morphology, and prototypic genetic founder lesions define only a small proportion of AML patients. The historical su...
Humans Translocation, Genetic Machine Learning Leukemia, Myeloid, Acute Cytogenetics Neoplasms, Second Primary Bayes Theorem Genomics Gene Expression Regulation, Leukemic Mutation
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