AIMC Topic: Gram-Negative Bacteria

Clear Filters Showing 21 to 30 of 41 articles

Predictive Model of Linear Antimicrobial Peptides Active against Gram-Negative Bacteria.

Journal of chemical information and modeling May 11, 2018
Antimicrobial peptides (AMPs) have been identified as a potential new class of anti-infectives for drug development. There are a lot of computational methods that try to predict AMPs. Most of them can only predict if a peptide will show any antimicro...
Cluster Analysis Antimicrobial Cationic Peptides Gram-Negative Bacteria Machine Learning Computer Simulation Models, Theoretical
View on PubMed DOI

Accurate prediction of Gram-negative bacterial secreted protein types by fusing multiple statistical features from PSI-BLAST profile.

SAR and QSAR in environmental research Apr 24, 2018
Gram-negative bacterial secreted proteins play different roles in invaded eukaryotic cells and cause various diseases. Prediction of Gram-negative bacterial secreted protein types is a meaningful and challenging task. In this paper, we develop a mult...
Bacterial Proteins Dipeptides Gram-Negative Bacteria Support Vector Machine Models, Statistical Structure-Activity Relationship
View on PubMed DOI

In vitro activity of eravacycline against 2213 Gram-negative and 2424 Gram-positive bacterial pathogens isolated in Canadian hospital laboratories: CANWARD surveillance study 2014-2015.

Diagnostic microbiology and infectious disease Dec 22, 2017
Gram-negative (n=2213) and Gram-positive (n=2424) pathogens isolated from patients in 13 Canadian hospitals in 2014 and 2015 were tested for in vitro susceptibility to eravacycline and comparators using the Clinical and Laboratory Standards Institute...
Laboratories, Hospital Gram-Negative Bacteria Tetracyclines Microbial Sensitivity Tests Humans Enterobacteriaceae Infections Canada Gram-Positive Bacteria Anti-Bacterial Agents Epidemiological Monitoring Enterobacteriaceae Gram-Positive Bacterial Infections Gram-Negative Bacterial Infections
View on PubMed DOI

An evidence of C16 fatty acid methyl esters extracted from microalga for effective antimicrobial and antioxidant property.

Microbial pathogenesis Dec 22, 2017
Fatty acid methyl esters (FAME) derived from lipids of microalgae is known to have wide bio-functional materials including antimicrobials. FAME is an ideal super-curator and superior anti-pathogenic. The present study evaluated the efficiency of FAME...
Anti-Bacterial Agents Microbial Sensitivity Tests Antioxidants Antifungal Agents Fungi Microalgae Gram-Negative Bacteria Palmitates Gram-Positive Bacteria Scenedesmus
View on PubMed DOI

Design, synthesis, antibacterial evaluation and molecular docking studies of some new quinoxaline derivatives targeting dihyropteroate synthase enzyme.

Bioorganic chemistry Dec 5, 2017
Development of new antimicrobial agents is a good solution to overcome drug-resistance problems. From this perspective, new quinoxaline derivatives bearing various bioactive heterocyclic moieties (thiadiazoles, oxadiazoles, pyrazoles and thiazoles) w...
Yersinia pestis Molecular Docking Simulation Drug Design Dihydropteroate Synthase Microbial Sensitivity Tests Hydrophobic and Hydrophilic Interactions Quinoxalines Catalytic Domain Protein Binding Anti-Bacterial Agents Levofloxacin Gram-Negative Bacteria Structure-Activity Relationship Gram-Positive Bacteria Molecular Structure Hydrogen Bonding
View on PubMed DOI

Synthesis and antimicrobial studies of novel derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-Acinetobacter baumannii agents.

Bioorganic & medicinal chemistry letters Dec 29, 2016
Microbial resistance to antibiotics is a global concern. The World Health Organization (WHO) has identified antimicrobial resistance as one the three greatest threats for human beings in the 21st century. Without urgent and coordinated action, the wo...
Gram-Positive Bacteria Binding Sites Benzoic Acid Pyrazoles Gram-Negative Bacteria Molecular Docking Simulation Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial Structure-Activity Relationship Catalytic Domain Acinetobacter baumannii Anti-Infective Agents
View on PubMed DOI

Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents.

Bioorganic & medicinal chemistry letters Dec 24, 2016
We attempted to optimize sulfonamide-based non-alkyne LpxC inhibitors by focusing on improvements in enzyme inhibitory and antibacterial activity. It was discovered that inhibitors possessing 2-aryl benzofuran as a hydrophobe exhibited good activity....
Gram-Negative Bacteria Amidohydrolases Structure-Activity Relationship Sulfonamides Anti-Bacterial Agents Drug Resistance, Bacterial Microbial Sensitivity Tests
View on PubMed DOI

Feature Fusion Based SVM Classifier for Protein Subcellular Localization Prediction.

Journal of integrative bioinformatics Dec 18, 2016
For the importance of protein subcellular localization in different branches of life science and drug discovery, researchers have focused their attentions on protein subcellular localization prediction. Effective representation of features from prote...
Bacterial Proteins Models, Biological Gram-Negative Bacteria Support Vector Machine
View on PubMed DOI

Synthesis, identification and in vitro biological evaluation of some novel quinoline incorporated 1,3-thiazinan-4-one derivatives.

Bioorganic & medicinal chemistry letters Jun 16, 2016
The present study describes the synthesis of two new series of 3-hydroxy-N-(4-oxo-2-phenyl-1,3-thiazinan-3-yl)-8-(trifluoromethyl)quinoline-2-carboxamide derivatives (4a-j) and 3-((7-chloroquinolin-4-ylamino)methyl)-2-phenyl-1,3-thiazinan-4-one deriv...
Anti-Bacterial Agents Plasmodium falciparum Antitubercular Agents Antimalarials Microbial Sensitivity Tests Spectroscopy, Fourier Transform Infrared Structure-Activity Relationship Magnetic Resonance Spectroscopy Mycobacterium tuberculosis Clostridium tetani Gram-Negative Bacteria Thiazines Quinolines
View on PubMed DOI

Predict Gram-Positive and Gram-Negative Subcellular Localization via Incorporating Evolutionary Information and Physicochemical Features Into Chou's General PseAAC.

IEEE transactions on nanobioscience Nov 12, 2015
In this study, we used structural and evolutionary based features to represent the sequences of gram-positive and gram-negative subcellular localizations. To do this, we proposed a normalization method to construct a normalize Position Specific Scori...
Support Vector Machine Models, Statistical Bayes Theorem Gram-Negative Bacteria Gram-Positive Bacteria Intracellular Space
View on PubMed DOI
Popular Topics
Recent Journals