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Gram-Negative Bacteria

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In vitro activity of eravacycline against 2213 Gram-negative and 2424 Gram-positive bacterial pathogens isolated in Canadian hospital laboratories: CANWARD surveillance study 2014-2015.

Diagnostic microbiology and infectious disease 29338931
Gram-negative (n=2213) and Gram-positive (n=2424) pathogens isolated from patients in 13 Canadian hospitals in 2014 and 2015 were tested for in vitro susceptibility to eravacycline and comparators using the Clinical and Laboratory Standards Institute...
Anti-Bacterial Agents Canada Enterobacteriaceae Enterobacteriaceae Infections Epidemiological Monitoring Gram-Negative Bacteria Gram-Negative Bacterial Infections Gram-Positive Bacteria Gram-Positive Bacterial Infections Humans Laboratories, Hospital Microbial Sensitivity Tests Tetracyclines
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Design, synthesis, antibacterial evaluation and molecular docking studies of some new quinoxaline derivatives targeting dihyropteroate synthase enzyme.

Bioorganic chemistry 29275262
Development of new antimicrobial agents is a good solution to overcome drug-resistance problems. From this perspective, new quinoxaline derivatives bearing various bioactive heterocyclic moieties (thiadiazoles, oxadiazoles, pyrazoles and thiazoles) w...
Anti-Bacterial Agents Catalytic Domain Dihydropteroate Synthase Drug Design Gram-Negative Bacteria Gram-Positive Bacteria Hydrogen Bonding Hydrophobic and Hydrophilic Interactions Levofloxacin Microbial Sensitivity Tests Molecular Docking Simulation Molecular Structure Protein Binding Quinoxalines Structure-Activity Relationship Yersinia pestis
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An evidence of C16 fatty acid methyl esters extracted from microalga for effective antimicrobial and antioxidant property.

Microbial pathogenesis 29277474
Fatty acid methyl esters (FAME) derived from lipids of microalgae is known to have wide bio-functional materials including antimicrobials. FAME is an ideal super-curator and superior anti-pathogenic. The present study evaluated the efficiency of FAME...
Anti-Bacterial Agents Antifungal Agents Antioxidants Fungi Gram-Negative Bacteria Gram-Positive Bacteria Microalgae Microbial Sensitivity Tests Palmitates Scenedesmus
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Feature Fusion Based SVM Classifier for Protein Subcellular Localization Prediction.

Journal of integrative bioinformatics 28187424
For the importance of protein subcellular localization in different branches of life science and drug discovery, researchers have focused their attentions on protein subcellular localization prediction. Effective representation of features from prote...
Bacterial Proteins Gram-Negative Bacteria Models, Biological Support Vector Machine
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Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents.

Bioorganic & medicinal chemistry letters 28082037
We attempted to optimize sulfonamide-based non-alkyne LpxC inhibitors by focusing on improvements in enzyme inhibitory and antibacterial activity. It was discovered that inhibitors possessing 2-aryl benzofuran as a hydrophobe exhibited good activity....
Amidohydrolases Anti-Bacterial Agents Drug Resistance, Bacterial Gram-Negative Bacteria Microbial Sensitivity Tests Structure-Activity Relationship Sulfonamides
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Synthesis and antimicrobial studies of novel derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-Acinetobacter baumannii agents.

Bioorganic & medicinal chemistry letters 28065568
Microbial resistance to antibiotics is a global concern. The World Health Organization (WHO) has identified antimicrobial resistance as one the three greatest threats for human beings in the 21st century. Without urgent and coordinated action, the wo...
Acinetobacter baumannii Anti-Infective Agents Benzoic Acid Binding Sites Catalytic Domain Drug Resistance, Multiple, Bacterial Gram-Negative Bacteria Gram-Positive Bacteria Microbial Sensitivity Tests Molecular Docking Simulation Pyrazoles Structure-Activity Relationship
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Synthesis, identification and in vitro biological evaluation of some novel quinoline incorporated 1,3-thiazinan-4-one derivatives.

Bioorganic & medicinal chemistry letters 28065567
The present study describes the synthesis of two new series of 3-hydroxy-N-(4-oxo-2-phenyl-1,3-thiazinan-3-yl)-8-(trifluoromethyl)quinoline-2-carboxamide derivatives (4a-j) and 3-((7-chloroquinolin-4-ylamino)methyl)-2-phenyl-1,3-thiazinan-4-one deriv...
Anti-Bacterial Agents Antimalarials Antitubercular Agents Clostridium tetani Gram-Negative Bacteria Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Mycobacterium tuberculosis Plasmodium falciparum Quinolines Spectroscopy, Fourier Transform Infrared Structure-Activity Relationship Thiazines
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Improving Recognition of Antimicrobial Peptides and Target Selectivity through Machine Learning and Genetic Programming.

IEEE/ACM transactions on computational biology and bioinformatics 28368808
Growing bacterial resistance to antibiotics is spurring research on utilizing naturally-occurring antimicrobial peptides (AMPs) as templates for novel drug design. While experimentalists mainly focus on systematic point mutations to measure the effec...
Algorithms Antimicrobial Cationic Peptides Computational Biology Decision Trees Drug Design Genetic Engineering Gram-Negative Bacteria Gram-Positive Bacteria Machine Learning Neural Networks, Computer
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Accurate prediction of Gram-negative bacterial secreted protein types by fusing multiple statistical features from PSI-BLAST profile.

SAR and QSAR in environmental research 29688029
Gram-negative bacterial secreted proteins play different roles in invaded eukaryotic cells and cause various diseases. Prediction of Gram-negative bacterial secreted protein types is a meaningful and challenging task. In this paper, we develop a mult...
Bacterial Proteins Dipeptides Gram-Negative Bacteria Models, Statistical Structure-Activity Relationship Support Vector Machine
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Predictive Model of Linear Antimicrobial Peptides Active against Gram-Negative Bacteria.

Journal of chemical information and modeling 29716188
Antimicrobial peptides (AMPs) have been identified as a potential new class of anti-infectives for drug development. There are a lot of computational methods that try to predict AMPs. Most of them can only predict if a peptide will show any antimicro...
Antimicrobial Cationic Peptides Cluster Analysis Computer Simulation Gram-Negative Bacteria Machine Learning Models, Theoretical
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