AIMC Topic: Hemolysis

Clear Filters Showing 21 to 30 of 33 articles

Design and synthesis of cell selective α/β-diastereomeric peptidomimetic with potent in vivo antibacterial activity against methicillin resistant S. Aureus.

Bioorganic chemistry Dec 26, 2017
Design of therapeutically viable antimicrobial peptides with cell selectivity against microorganisms is an important step towards the development of new antimicrobial agents. Here, we report four de novo designed, short amphipathic sequences based on...
Peptidomimetics Female Phosphatidylglycerols Animals Stereoisomerism Amino Acid Sequence Microbial Sensitivity Tests Pseudomonas aeruginosa Keratinocytes Acinetobacter baumannii Humans Enterococcus faecalis Anti-Bacterial Agents Hemolysis Phosphatidylcholines Lipid Bilayers Erythrocytes Escherichia coli Methicillin-Resistant Staphylococcus aureus Mice, Inbred BALB C
View on PubMed DOI

Automatic hemolysis identification on aligned dual-lighting images of cultured blood agar plates.

Computer methods and programs in biomedicine Dec 18, 2017
BACKGROUND AND OBJECTIVE: The recent introduction of Full Laboratory Automation systems in clinical microbiology opens to the availability of streams of high definition images representing bacteria culturing plates. This creates new opportunities to ...
Agar Signal Processing, Computer-Assisted Reproducibility of Results Programming Languages Urinary Tract Infections Humans Bacteria Hemolysis Models, Statistical Lighting Electronic Data Processing Software Algorithms
View on PubMed DOI

HemoPred: a web server for predicting the hemolytic activity of peptides.

Future medicinal chemistry Feb 17, 2017
AIM: Toxicity arising from hemolytic activity of peptides hinders its further progress as drug candidates.
Hemolysis Hemolytic Agents Peptides Databases, Protein Amino Acid Sequence Humans Machine Learning Software Computer Simulation
View on PubMed DOI

Antihemolytic and antioxidant properties of pearl powder against 2,2'-azobis(2-amidinopropane) dihydrochloride-induced hemolysis and oxidative damage to erythrocyte membrane lipids and proteins.

Journal of food and drug analysis Dec 1, 2016
Pearl powder, a well-known traditional mineral medicine, is reported to be used for well-being and to treat several diseases from centuries in Taiwan and China. We investigated the in vitro antihemolytic and antioxidant properties of pearl powder tha...
Humans Membrane Lipids Powders Animals Oxidative Stress Erythrocytes Amidines Pinctada China Antioxidants Erythrocyte Membrane Hemolysis Membrane Proteins
View on PubMed DOI

A Web Server and Mobile App for Computing Hemolytic Potency of Peptides.

Scientific reports Mar 8, 2016
Numerous therapeutic peptides do not enter the clinical trials just because of their high hemolytic activity. Recently, we developed a database, Hemolytik, for maintaining experimentally validated hemolytic and non-hemolytic peptides. The present stu...
Sequence Analysis, Protein Hemolytic Agents Internet Amino Acid Sequence Hemolysis Computer Simulation Mobile Applications Peptides Support Vector Machine Databases, Protein Humans
View on PubMed DOI

ConsAMPHemo: A computational framework for predicting hemolysis of antimicrobial peptides based on machine learning approaches.

Protein science : a publication of the Protein Society Jul 1, 2025
Many antimicrobial peptides (AMPs) function by disrupting the cell membranes of microbes. While this ability is crucial for their efficacy, it also raises questions about their safety. Specifically, the membrane-disrupting ability could lead to hemol...
Machine Learning Deep Learning Hemolysis Humans Antimicrobial Peptides
View on PubMed DOI

Deep-Learning-Based Approaches for Rational Design of Stapled Peptides With High Antimicrobial Activity and Stability.

Microbial biotechnology Mar 1, 2025
Antimicrobial peptides (AMPs) face stability and toxicity challenges in clinical use. Stapled modification enhances their stability and effectiveness, but its application in peptide design is rarely reported. This study built ten prediction models fo...
Microbial Sensitivity Tests Bacteria Protein Stability Anti-Bacterial Agents Drug Design Deep Learning Humans Hemolysis Antimicrobial Peptides
View on PubMed DOI

[Study on lightweight plasma recognition algorithm based on depth image perception].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi Feb 25, 2025
In the clinical stage, suspected hemolytic plasma may cause hemolysis illness, manifesting as symptoms such as heart failure, severe anemia, etc. Applying a deep learning method to plasma images significantly improves recognition accuracy, so that th...
Algorithms Deep Learning Image Processing, Computer-Assisted Hemolysis Humans Plasma
View on PubMed DOI

[Optimization of centrifugal artificial heart pump blade parameters based on back propagation neural network and grey wolf optimization algorithm].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi Dec 25, 2024
The impeller, as a key component of artificial heart pumps, experiences high shear stress due to its rapid rotation, which may lead to hemolysis. To enhance the hemolytic performance of artificial heart pumps and identify the optimal combination of b...
Humans Neural Networks, Computer Algorithms Stress, Mechanical Hemolysis Computer Simulation Equipment Design Heart-Assist Devices
View on PubMed DOI

Structure-aware deep learning model for peptide toxicity prediction.

Protein science : a publication of the Protein Society Jul 1, 2024
Antimicrobial resistance is a critical public health concern, necessitating the exploration of alternative treatments. While antimicrobial peptides (AMPs) show promise, assessing their toxicity using traditional wet lab methods is both time-consuming...
Neural Networks, Computer Deep Learning Hemolysis Antimicrobial Peptides
View on PubMed DOI
Popular Topics
Recent Journals