AIMC Topic: Insulin

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Predictors of glycaemic improvement in children and young adults with type 1 diabetes and very elevated HbA1c using the MiniMed 780G system.

Diabetes, obesity & metabolism
AIMS: This study aimed to identify key factors with the greatest influence on glycaemic outcomes in young individuals with type 1 diabetes (T1D) and very elevated glycaemia after 3 months of automated insulin delivery (AID).

Hybrid Control Policy for Artificial Pancreas via Ensemble Deep Reinforcement Learning.

IEEE transactions on bio-medical engineering
OBJECTIVE: The artificial pancreas (AP) shows promise for closed-loop glucose control in type 1 diabetes mellitus (T1DM). However, designing effective control policies for the AP remains challenging due to complex physiological processes, delayed ins...

The effect of renal function on the clinical outcomes and management of patients hospitalized with hyperglycemic crises.

Frontiers in endocrinology
BACKGROUND: The global prevalence of diabetes has been rising rapidly in recent years, leading to an increase in patients experiencing hyperglycemic crises like diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). Patients with imp...

Developing an AI-Based clinical decision support system for basal insulin titration in type 2 diabetes in primary Care: A Mixed-Methods evaluation using heuristic Analysis, user Feedback, and eye tracking.

International journal of medical informatics
BACKGROUND AND AIM: The progressive nature of type 2 diabetes often, in time, necessitates basal insulin therapy to achieve glycemic targets. However, despite standardized titration algorithms, many people remain poorly controlled after initiating in...

Modeling the fasting blood glucose response to basal insulin adjustment in type 2 diabetes: An explainable machine learning approach on real-world data.

International journal of medical informatics
INTRODUCTION: Optimal basal insulin titration for people with type 2 diabetes is vital to effectively reducing the risk of complications. However, a sizeable proportion of people (30-50 %) remain in suboptimal glycemic control six months post-initiat...

Parental perspectives following the implementation of advanced hybrid closed-loop therapy in children and adolescents with type 1 diabetes and elevated glycaemia.

Diabetic medicine : a journal of the British Diabetic Association
AIMS: To identify from a parental perspective facilitators and barriers of effective implementation of advanced hybrid closed-loop (AHCL) therapy in children and adolescents with type 1 diabetes (T1D) with elevated glycaemia.

Physiological model-based machine learning for classifying patients with binge-eating disorder (BED) from the Oral Glucose Tolerance Test (OGTT) curve.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: Binge eating disorder (BED) is the most frequent eating disorder, often confused with obesity, with which it shares several characteristics. Early identification could enable targeted therapeutic interventions. In this study...

Prediction of People With Type 2 Diabetes Not Achieving HbA1c Target After Initiation of Fast-Acting Insulin Therapy: Using Machine Learning Framework on Clinical Trial Data.

Journal of diabetes science and technology
BACKGROUND AND AIMS: Glycemic control is crucial for people with type 2 diabetes. However, only about half achieve the advocated HbA1c target of ≤7%. Identifying those who will probably struggle to reach this target may be valuable as they require ad...

Learning control-ready forecasters for Blood Glucose Management.

Computers in biology and medicine
Type 1 diabetes (T1D) presents a significant health challenge, requiring patients to actively manage their blood glucose (BG) levels through regular bolus insulin administration. Automated control solutions based on machine learning (ML) models could...

An automatic deep reinforcement learning bolus calculator for automated insulin delivery systems.

Scientific reports
In hybrid automatic insulin delivery (HAID) systems, meal disturbance is compensated by feedforward control, which requires the announcement of the meal by the patient with type 1 diabetes (DM1) to achieve the desired glycemic control performance. Th...