AIMS: The efficacy of cariprazine for major depressive disorder (MDD) (adjunctive therapy) and bipolar I (BP-I) depression has been demonstrated in clinical trials. This study evaluated the real-world effectiveness of cariprazine in reducing depressi...
Clinical pharmacology and therapeutics
Apr 8, 2025
Measuring medication discontinuation in claims data primarily relies on the gaps between prescription fills, but such definitions are rarely validated. This study aimed to establish a natural language processing (NLP)-based validation framework to ev...
IEEE journal of biomedical and health informatics
Feb 10, 2025
Accurate detection and prevalence estimation of behavioral health conditions, such as opioid use disorder (OUD), are crucial for identifying at-risk individuals, determining treatment needs, monitoring prevention and intervention efforts, and recruit...
Identifying patients with rare diseases like alpha-1 antitrypsin deficiency (AATD) is challenging. Machine-learning models may be trained to identify patients with rare diseases using large-scale, real-world databases, whereas electronic medical reco...
Healthcare fraud, waste and abuse are costly problems that have huge impact on society. Traditional approaches to identify non-compliant claims rely on auditing strategies requiring trained professionals, or on machine learning methods requiring labe...
BMC medical informatics and decision making
Feb 3, 2022
BACKGROUND: Accurate prediction of healthcare costs is important for optimally managing health costs. However, methods leveraging the medical richness from data such as health insurance claims or electronic health records are missing.
Identification of medical conditions using claims data is generally conducted with algorithms based on subject-matter knowledge. However, these claims-based algorithms (CBAs) are highly dependent on the knowledge level and not necessarily optimized f...
BACKGROUND: There are few large studies examining and predicting the diversified cardiovascular/noncardiovascular comorbidity relationships with stroke. We investigated stroke risks in a very large prospective cohort of patients with multimorbidity, ...
BACKGROUND: The clinical impact of postoperative opioid use requires accurate prediction strategies to identify at-risk patients. We utilize preoperative claims data to predict postoperative opioid refill and new persistent use in opioid-naïve patien...
Journal of the American Heart Association
Sep 29, 2020
Background Real-world healthcare data are an important resource for epidemiologic research. However, accurate identification of patient cohorts-a crucial first step underpinning the validity of research results-remains a challenge. We developed and e...
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