AIMC Topic: Intracellular Signaling Peptides and Proteins

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Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data.

PloS one Jul 26, 2018
Chemogenomic approaches involving highly annotated compound sets and cell based high throughput screening are emerging as a means to identify novel drug targets. We have previously screened a collection of highly characterized kinase inhibitors (Khan...
Humans Machine Learning Drug Discovery Antiviral Agents Cell Line Protein Serine-Threonine Kinases Cytomegalovirus Cytomegalovirus Infections RNA, Small Interfering Virus Replication Protein Kinase Inhibitors Intracellular Signaling Peptides and Proteins
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Classification of signaling proteins based on molecular star graph descriptors using Machine Learning models.

Journal of theoretical biology Aug 20, 2015
Signaling proteins are an important topic in drug development due to the increased importance of finding fast, accurate and cheap methods to evaluate new molecular targets involved in specific diseases. The complexity of the protein structure hinders...
Humans Machine Learning Signal Transduction Databases, Protein Quantitative Structure-Activity Relationship Intracellular Signaling Peptides and Proteins
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