AIMC Topic: Knowledge Bases

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Introducing the Big Knowledge to Use (BK2U) challenge.

Annals of the New York Academy of Sciences Oct 17, 2016
The purpose of the Big Data to Knowledge initiative is to develop methods for discovering new knowledge from large amounts of data. However, if the resulting knowledge is so large that it resists comprehension, referred to here as Big Knowledge (BK),...
Models, Neurological Pharmaceutical Preparations Drug Interactions Image Processing, Computer-Assisted Computational Biology Data Mining Image Interpretation, Computer-Assisted Systematized Nomenclature of Medicine Translational Research, Biomedical Knowledge Bases Humans Animals Decision Making, Computer-Assisted Terminology as Topic Intracranial Hemorrhages
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Boolean regulatory network reconstruction using literature based knowledge with a genetic algorithm optimization method.

BMC bioinformatics Oct 6, 2016
BACKGROUND: Prior knowledge networks (PKNs) provide a framework for the development of computational biological models, including Boolean models of regulatory networks which are the focus of this work. PKNs are created by a painstaking process of lit...
Humans Software Algorithms Publications Gene Regulatory Networks Models, Biological Computer Simulation Models, Genetic Knowledge Bases
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An evidence synthesis of the international knowledge base for new care models to inform and mobilise knowledge for multispecialty community providers (MCPs).

Systematic reviews Oct 1, 2016
BACKGROUND: NHS England's Five Year Forward View (NHS England, Five Year Forward View, 2014) formally introduced a strategy for new models of care driven by simultaneous pressures to contain costs, improve care and deliver services closer to home thr...
Community Networks England Community Health Services Knowledge Bases State Medicine Humans Evidence-Based Medicine Medicine Cost-Benefit Analysis
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A knowledge-based expert rule system for predicting mutagenicity (Ames test) of aromatic amines and azo compounds.

Toxicology Sep 16, 2016
Cancer is one of the main causes of death in Western countries, and a major issue for human health. Prolonged exposure to a number of chemicals was observed to be one of the primary causes of cancer in occupationally exposed persons. Thus, the develo...
Amines Mutagens Mutagenicity Tests Databases, Factual Models, Theoretical Knowledge Bases Azo Compounds Molecular Structure Humans
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DMAK: A curated pan-cancer DNA methylation annotation knowledgebase.

Bioengineered Aug 12, 2016
Pan-cancer analysis can identify cell- and tissue-specific genomic loci and regions with underlying biological functions. Here we present an online curated DNA Methylation Annotation Knowledgebase, DMAK, which includes the pan-cancer analysis results...
DNA Methylation Knowledge Bases CpG Islands Humans Neoplasms
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Chemogenomics knowledgebase and systems pharmacology for hallucinogen target identification-Salvinorin A as a case study.

Journal of molecular graphics & modelling Aug 8, 2016
Drug abuse is a serious problem worldwide. Recently, hallucinogens have been reported as a potential preventative and auxiliary therapy for substance abuse. However, the use of hallucinogens as a drug abuse treatment has potential risks, as the funda...
Genomics Models, Molecular Reproducibility of Results Databases, Chemical Diterpenes, Clerodane Knowledge Bases Hallucinogens
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Literature-based knowledgebase of pancreatic cancer gene to prioritize the key genes and pathways.

Journal of genetics and genomics = Yi chuan xue bao Jul 9, 2016
Pancreatic Neoplasms Knowledge Bases Oncogenes Humans
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Publication, discovery and interoperability of Clinical Decision Support Systems: A Linked Data approach.

Journal of biomedical informatics Jul 8, 2016
BACKGROUND: The high costs involved in the development of Clinical Decision Support Systems (CDSS) make it necessary to share their functionality across different systems and organizations. Service Oriented Architectures (SOA) have been proposed to a...
Knowledge Discovery Semantic Web Publishing Publications Knowledge Bases Humans Decision Support Systems, Clinical
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An ontology-driven, case-based clinical decision support model for removable partial denture design.

Scientific reports Jun 14, 2016
We present the initial work toward developing a clinical decision support model for specific design of removable partial dentures (RPDs) in dentistry. We developed an ontological paradigm to represent knowledge of a patient's oral conditions and dent...
Natural Language Processing Knowledge Bases Denture Retention Denture, Partial, Removable Biological Ontologies Decision Support Techniques Reproducibility of Results Decision Support Systems, Clinical Humans Algorithms
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A knowledge base for tracking the impact of genomics on population health.

Genetics in medicine : official journal of the American College of Medical Genetics Jun 9, 2016
PURPOSE: We created an online knowledge base (the Public Health Genomics Knowledge Base (PHGKB)) to provide systematically curated and updated information that bridges population-based research on genomics with clinical and public health applications...
Genomics Databases, Genetic Internet Humans Public Health Knowledge Bases
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