AIMC Topic: Lab-On-A-Chip Devices

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Advancements in Circulating Tumor Cell Detection for Early Cancer Diagnosis: An Integration of Machine Learning Algorithms with Microfluidic Technologies.

Biosensors
Circulating tumor cells (CTCs) are vital indicators of metastasis and provide a non-invasive method for early cancer diagnosis, prognosis, and therapeutic monitoring. However, their low prevalence and heterogeneity in the bloodstream pose significant...

High-throughput microfluidics for precise separation and focusing of circulating tumor cells with optimized triangular microchannel design.

Talanta
The precise separation and focusing of circulating tumor cells (CTCs) from blood cells are crucial for advancing cancer diagnosis, optimizing therapeutic strategies, and fostering progress in cellular research. Inertial microfluidics offers an effici...

Transformative biomedical devices to overcome biomatrix effects.

Biosensors & bioelectronics
The emergence of high-performance biomedical devices and sensing technologies highlights the technological advancements in the field. Recently during COVID-19 pandemic, biosensors played an important role in medical diagnostics and disease monitoring...

Sensing the Future of Thrombosis Management: Integrating Vessel-on-a-Chip Models, Advanced Biosensors, and AI-Driven Digital Twins.

ACS sensors
Thrombotic events, such as strokes and deep vein thrombosis, remain a significant global health burden, with traditional diagnostic methods often failing to capture the complex, patient-specific nuances of thrombosis risk. This Perspective explores t...

Automated Electrical Detection of Proteins for Oral Squamous Cell Carcinoma in an Integrated Microfluidic Chip Using Multi-Frequency Impedance Cytometry and Machine Learning.

Sensors (Basel, Switzerland)
Proteins can act as suitable biomarkers for the prognosis and diagnosis of certain conditions and can help us gain an understanding of the fundamental processes that occur inside an organism. In this work, we present a fully automated machine learnin...

Machine Learning Assisted Nanofluidic Array for Multiprotein Detection.

ACS nano
Solid-state nanopore and nanochannel biosensors have revolutionized protein detection by offering label-free, highly sensitive analyses. Traditional sensing systems (1st and 2nd stages) primarily focus on inner wall (IW) interactions, facing challeng...

Neural Network-Enhanced Electrochemical/SERS Dual-Mode Microfluidic Platform for Accurate Detection of Interleukin-6 in Diabetic Wound Exudates.

Analytical chemistry
Interleukin-6 (IL-6) plays a pivotal role in the inflammatory response of diabetic wounds, providing critical insights for clinicians in the development of personalized treatment strategies. However, the low concentration of IL-6 in biological sample...

TimePAD─Unveiling Temporal Sequence ELISA Signal by Deep Learning for Rapid Readout and Improved Accuracy in a Microfluidic Paper-Based Analytical Platform.

Analytical chemistry
The integration of paper-based microfluidics with deep learning represents a pivotal trend in enhancing diagnostic capabilities. This paper introduces a new approach to improve the performance of a paper-based microfluidic enzyme-linked immunosorbent...

Machine Learning Identification and Classification of Mitosis and Migration of Cancer Cells in a Lab-on-CMOS Capacitance Sensing Platform.

IEEE journal of biomedical and health informatics
Cell culture assays play a vital role in various fields of biology. Conventional assay techniques like immunohistochemistry, immunofluorescence, and flow cytometry offer valuable insights into cell phenotype and behavior. However, each of these techn...

An Integrated Microfluidic Microwave Array Sensor with Machine Learning for Enrichment and Detection of Mixed Biological Solution.

Biosensors
In this work, an integrated microfluidic microwave array sensor is proposed for the enrichment and detection of mixed biological solution. In individuals with urinary tract infections or intestinal health issues, the levels of white blood cells (WBCs...