Proceedings of the National Academy of Sciences of the United States of America
Dec 3, 2025
Currently approved vaccines for the prevention of malaria provide only partial protection against disease due to high variability in the quality of induced antibodies. These vaccines present the unstructured central repeat region, as well as the C-te...
BACKGROUND: The National Framework for Malaria Elimination, formulated in 2016, aims to eliminate malaria in India by 2030, focusing on the districts as the strategic units for planning and implementing intervention measures. In this study, the spati...
BACKGROUND: Machine learning algorithms have been used to predict malaria risk and severity, identify immunity biomarkers for malaria vaccine candidates, and determine molecular biomarkers of antimalarial drug resistance. Developing these prediction ...
BACKGROUND: In sub-Saharan Africa, Plasmodium falciparum is the most prevalent species of malaria parasites. In endemic areas, malaria is mainly diagnosed using microscopy or rapid diagnostic tests (RDTs), which have limited sensitivity, and microsco...
Continuous high-resolution imaging of the disease-mediating blood stages of the human malaria parasite Plasmodium falciparum faces challenges due to photosensitivity, small parasite size, and the anisotropy and large refractive index of host erythroc...
Accurate malaria diagnosis with precise identification of Plasmodium species is crucial for an effective treatment. While microscopy is still the gold standard in malaria diagnosis, it relies heavily on trained personnel. Artificial intelligence (AI)...
Over the past few decades, machine learning and deep learning (DL) have incredibly influenced a broader range of scientific disciplines. DL-based strategies have displayed superior performance in image processing compared to conventional standard met...
Diagnosing malaria using standard techniques is time-consuming. With limited staffing in many laboratories, this may lead to delays in reporting. Innovative technologies are changing the diagnostic landscape and may help alleviate staffing shortages....
Immunization through repeated direct venous inoculation of Plasmodium falciparum (Pf) sporozoites (PfSPZ) under chloroquine chemoprophylaxis, using the PfSPZ Chemoprophylaxis Vaccine (PfSPZ-CVac), induces high-level protection against controlled huma...
Field-derived metrics are critical for effective control of malaria, particularly in sub-Saharan Africa where the disease kills over half a million people yearly. One key metric is entomological inoculation rate, a direct measure of transmission inte...
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