AIMC Topic: Artemisinins

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Unraveling tissue-specific molecular targets of dihydroartemisinin in non-small cell lung cancer: an integrative machine learning and network pharmacology approach.

Medical oncology (Northwood, London, England)
Non-small cell lung cancer (NSCLC) presents significant therapeutic challenges due to resistance and immune evasion. Dihydroartemisinin (DHA), a derivative of artemisinin, exhibits broad anti-tumor activity, but its molecular targets and mechanisms i...

Automatic detection of harmful cyanobacterial genera using deep CNN models and artemisinin optimization.

Scientific reports
Concerns over the spread of Cyanobacteria, which can lead to dangerous blooms that harm drinking water quality and, therefore, the health of plants and animals, are being raised by global warming. Traditional methods for assessing the amount of toxic...

How to use learning curves to evaluate the sample size for malaria prediction models developed using machine learning algorithms.

Malaria journal
BACKGROUND: Machine learning algorithms have been used to predict malaria risk and severity, identify immunity biomarkers for malaria vaccine candidates, and determine molecular biomarkers of antimalarial drug resistance. Developing these prediction ...

QSAR Study of Artemisinin Analogues as Antimalarial Drugs by Neural Network and Replacement Method.

Drug research
Quantitative structure-activity relationship (QSAR) models were derived for 179 analogues of artemisinin, a potent antimalarial agent. Molecular descriptors derived solely from molecular structure were used to represent molecular structure. Utilizing...

FABRICATION AND EVALUATION OF SMART NANOCRYSTALS OF ARTEMISININ FOR ANTIMALARIAL AND ANTIBACTERIAL EFFICACY.

African journal of traditional, complementary, and alternative medicines : AJTCAM
BACKGROUND: Nanocrystals have the potential to substantially increase dissolution rate, solubility with subsequent enhanced bioavailability via the oral route of a range of poor water soluble drugs. Regardless of other issues, scale up of the batch s...

[Effect of dihydroartemisinin on multidrug resistance of human oral squamous cell carcinoma cell line KBV200 by regulating ROS-MAPK pathway].

Shanghai kou qiang yi xue = Shanghai journal of stomatology
PURROSE: To investigate the effect of dihydroartemisinin (DHA) on multidrug resistance of human oral squamous cell carcinoma cell line KBV200 and to explore its relationship with ROS-MAPK pathway.