AIMC Topic: Mice, Obese

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Machine-Learning-Guided Peptide Drug Discovery: Development of GLP-1 Receptor Agonists with Improved Drug Properties.

Journal of medicinal chemistry Jul 8, 2024
Peptide-based drug discovery has surged with the development of peptide hormone-derived analogs for the treatment of diabetes and obesity. Machine learning (ML)-enabled quantitative structure-activity relationship (QSAR) approaches have shown great p...
Humans Machine Learning Animals Male Peptides Drug Discovery Mice Mice, Inbred C57BL Obesity Quantitative Structure-Activity Relationship Mice, Obese Glucagon-Like Peptide-1 Receptor Agonists
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The Anti-Adiposity Mechanisms of Ampelopsin and Vine Tea Extract in High Fat Diet and Alcohol-Induced Fatty Liver Mouse Models.

Molecules (Basel, Switzerland) Jan 18, 2022
(AG) is an ancient medicinal plant that is mainly distributed and used in southwest China. It exerts therapeutic effects, such as antioxidant, anti-diabetic, and anti-inflammatory activities, reductions in blood pressure and cholesterol and hepatopr...
Animals Male Mice Antioxidants Plant Extracts Rats Rats, Sprague-Dawley Mice, Inbred C57BL Obesity Diet, High-Fat Anti-Obesity Agents Tea Flavonoids Mice, Inbred ICR Lipid Metabolism Non-alcoholic Fatty Liver Disease Adiposity 3T3-L1 Cells Phytotherapy Lipogenesis Fatty Liver, Alcoholic Mice, Obese
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Robust mouse tracking in complex environments using neural networks.

Communications biology Mar 29, 2019
The ability to track animals accurately is critical for behavioral experiments. For video-based assays, this is often accomplished by manipulating environmental conditions to increase contrast between the animal and the background in order to achieve...
Neural Networks, Computer Female Animals Male Mice Mice, Nude Housing, Animal Models, Animal Behavior, Animal Locomotion Mice, Obese Photoperiod
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