Ultrasound Localization Microscopy (ULM) can map microvessels at a resolution of a few micrometers ( [Formula: see text]). Transcranial ULM remains challenging in presence of aberrations caused by the skull, which lead to localization errors. Herein,...
Urinary tract infection (UTI) is a common disorder. Its diagnosis can be made by microscopic examination of voided urine for markers of infection. This manual technique is technically difficult, time-consuming and prone to inter-observer errors. The ...
Staining is a crucial step in histopathology that prepares tissue sections for microscopic examination. Hematoxylin and eosin (H&E) staining, also known as basic or routine staining, is used in 80% of histopathology slides worldwide. To enhance the h...
The development of high-resolution microscopes has made it possible to investigate cellular processes in 3D and over time. However, observing fast cellular dynamics remains challenging because of photobleaching and phototoxicity. Here we report the i...
Light-sheet microscopes enable rapid high-resolution imaging of biological specimens; however, biological processes span spatiotemporal scales. Moreover, long-term phenotypes are often instigated by rare or fleeting biological events that are difficu...
The diagnosis of kidney disease often involves analysing urine sediment particles. Traditionally, urinalysis was performed manually by collecting urine samples and using a centrifuge, which was prone to manual errors and relied on labour-intensive pr...
. Ultrasound localization microscopy (ULM) enables microvascular reconstruction by localizing microbubbles (MBs). Although ULM can obtain microvascular images that are beyond the ultimate resolution of the ultrasound (US) diffraction limit, it requir...
Recent work shows that the developmental potential of progenitor cells in the HH10 chick brain changes rapidly, accompanied by subtle changes in morphology. This demands increased temporal resolution for studies of the brain at this stage, necessitat...
Computer methods and programs in biomedicine
Nov 13, 2023
BACKGROUND AND OBJECTIVE: The classification of bone marrow (BM) cells by light microscopy is an important cornerstone of hematological diagnosis, performed thousands of times a day by highly trained specialists in laboratories worldwide. As the manu...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Nov 4, 2023
Conventional histopathology involves expensive and labor-intensive processes that often consume tissue samples, rendering them unavailable for other analyses. We present a novel end-to-end workflow for pathology powered by hyperspectral microscopy an...
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