OBJECTIVE: This study aimed to improve treatment effectiveness in childhood-onset systemic lupus erythematosus (cSLE) by developing machine learning algorithms integrated with pharmacokinetic parameters to predict individualized tacrolimus dosing for...
BACKGROUND: Fracture healing is a complex, time-dependent process governed by biological and mechanical factors, including implant properties. While finite element (FE) modeling provides detailed mechanobiological insights into this process, its comp...
European journal of clinical pharmacology
Sep 1, 2025
PURPOSE: This study develops and compares population pharmacokinetics (PopPK) models and machine learning methods, including neural networks, to predict steady-state trough concentrations in pediatric patients and provide improved dosing recommendati...
Journal of the science of food and agriculture
Sep 1, 2025
BACKGROUND: The present study aimed to measure bioavailability (BA) indicators, including epithelial barrier function, apparent permeability (P) and efflux ratio, of 84 types of phytochemicals using Caco-2 cell and to develop predictive model systems...
Decades of research into the molecular signalling determinants of B cell fates, and recent progress in characterising the genetic drivers of lymphoma, has led to a detailed understanding of B cell malignancies but also revealed daunting heterogeneity...
Cell motility in dense cell collectives is pivotal in various diseases like cancer metastasis and asthma. A central aspect in these phenomena is the heterogeneity in cell motility, but identifying the motility of individual cells is challenging. Prev...
Journal of controlled release : official journal of the Controlled Release Society
Aug 10, 2025
The lymphatic system hosts a large number of therapeutic targets that can be used to modulate a wide range of diseases including cancers, autoimmune and inflammatory disorders, infectious diseases and metabolic syndrome; however, drug access to the l...
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Aug 1, 2025
BACKGROUND: Mycophenolate mofetil (MMF), a cornerstone immunosuppressant for lupus nephritis, is increasingly used off-label in pediatric immune-mediated renal diseases. The aims of this study were to develop and validate pharmacokinetic models for m...
PURPOSE OF REVIEW: To summarize recent developments in the understanding of the pharmacology of the hypnotic and opioid drugs, with relevance to target-controlled infusions and newer pharmacokinetic models.
Aedes aegypti and Aedes albopictus are 2 medically important vectors that have established populations globally. In the United States, Ae. aegypti populations declined post-Ae. albopictus introduction, though both species now can be readily found thr...
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