Mechanistic models have been used for centuries to describe complex interconnected processes, including biological ones. As the scope of these models has widened, so have their computational demands. This complexity can limit their suitability when r...
Journal of the Royal Society, Interface
Apr 19, 2023
Increasing fungicide dose tends to lead to better short-term control of plant diseases. However, high doses select more rapidly for fungicide resistant strains, reducing long-term disease control. When resistance is qualitative and complete-i.e. resi...
Oral medicines represent the largest pharmaceutical market area. To achieve a therapeutic effect, a drug must penetrate the intestinal walls, the main absorption site for orally delivered active pharmaceutical ingredients (APIs). Indeed, predicting d...
Progress in biophysics and molecular biology
Apr 15, 2023
The constrained disorder principle (CDP) defines systems based on their degree of disorder bounded by dynamic boundaries. The principle explains stochasticity in living and non-living systems. Denis Noble described the importance of stochasticity in ...
Gait recognition, the task of identifying an individual based on their unique walking style, can be difficult because walking styles can be influenced by external factors such as clothing, viewing angle, and carrying conditions. To address these chal...
We report on the development of separated and laterally arranged two-leg (SLTL) models with/without differentiated leg properties and their use as the dynamic running and turning templates for a hexapod robot. The laterally arranged two-leg morpholog...
To solve the problem of inaccurate prediction caused by the lack of representativeness of samples due to the small sample size of the collected clinical data when using machine learning methods to predict drug concentration in plasma and describe the...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Feb 12, 2023
Annelids such as earthworms are considered to have central pattern generators (CPGs) that generate rhythms in neural circuits to coordinate the deformation of body segments for effective locomotion. At present, the states of earthworm-like robot segm...
Metabolism is characterised by chemical reactions linked to each other, creating a complex network structure. The whole metabolic network is divided into pathways of chemical reactions, such that every pathway is a metabolic function. A simplified re...
BACKGROUND: Therapeutic drug monitoring (TDM) and model-informed precision dosing (MIPD) have greatly benefitted from computational and mathematical advances over the past 60 years. Furthermore, the use of artificial intelligence (AI) and machine lea...