AIMC Topic: Nerve Tissue Proteins

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Deep learning analyses of splicing variants identify the link of PCP4 with amyotrophic lateral sclerosis.

Brain : a journal of neurology Jul 7, 2025
Amyotrophic lateral sclerosis (ALS) is a severe motor neuron disease, with most sporadic cases lacking clear genetic causes. Abnormal pre-mRNA splicing is a fundamental mechanism in neurodegenerative diseases. For example, TAR DNA-binding protein 43 ...
Deep Learning Nerve Tissue Proteins Humans Introns RNA Splicing Mutation Amyotrophic Lateral Sclerosis
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Integrative PPI network and random forest analysis identifies KIF4A, TOP2A, and ASPM protein macromolecules as novel protein biomarkers in renal carcinoma pathogenesis.

International journal of biological macromolecules Jun 1, 2025
The pathogenesis of kidney cancer is not fully understood, so there is an urgent need to identify new biomarkers to improve diagnosis and treatment. The study identified KIF4A, TOP2A and ASPM as novel protein biomarkers for renal cancer and explored ...
DNA Topoisomerases, Type II Kidney Neoplasms Carcinoma, Renal Cell Kinesins Poly-ADP-Ribose Binding Proteins Epithelial-Mesenchymal Transition Random Forest Nerve Tissue Proteins Cell Line, Tumor Protein Interaction Maps Biomarkers, Tumor Computational Biology Humans Gene Expression Profiling Prognosis Gene Expression Regulation, Neoplastic
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An enhanced workflow for variant interpretation in UniProtKB/Swiss-Prot improves consistency and reuse in ClinVar.

Database : the journal of biological databases and curation Jan 1, 2019
Personalized genomic medicine depends on integrated analyses that combine genetic and phenotypic data from individual patients with reference knowledge of the functional and clinical significance of sequence variants. Sources of this reference knowle...
Zinc Finger Protein Gli3 Workflow Knowledge Bases Databases, Protein Genetic Variation Nerve Tissue Proteins Copper-Transporting ATPases
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CAMELOT: A machine learning approach for coarse-grained simulations of aggregation of block-copolymeric protein sequences.

The Journal of chemical physics Dec 28, 2015
We report the development and deployment of a coarse-graining method that is well suited for computer simulations of aggregation and phase separation of protein sequences with block-copolymeric architectures. Our algorithm, named CAMELOT for Coarse-g...
Humans Machine Learning Amino Acid Sequence Molecular Sequence Data Computer Simulation Nerve Tissue Proteins Huntingtin Protein
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Correlation of Brain Neuropeptide (Nesfatin-1 and Orexin-A) Concentrations with Anthropometric and Biochemical Parameters in Malnourished Children.

Journal of clinical research in pediatric endocrinology Sep 1, 2015
OBJECTIVE: Malnutrition continues to be a leading cause of stunted growth in many countries. This study aimed to investigate serum nesfatin-1 and orexin-A levels in underweight children and the potential correlations of these levels with anthropometr...
Nerve Tissue Proteins Child Nutrition Disorders Thyrotropin Body Mass Index Orexins Calcium-Binding Proteins Anthropometry Body Weight Case-Control Studies Nucleobindins Body Height Multivariate Analysis Female Child Child, Preschool Vitamin B 12 Humans Thyroxine Male Enzyme-Linked Immunosorbent Assay DNA-Binding Proteins
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