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Nerve Tissue Proteins

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Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism.

BMC bioinformatics 26047810
BACKGROUND: People with an autistic spectrum disorder (ASD) display a variety of characteristic behavioral traits, including impaired social interaction, communication difficulties and repetitive behavior. This complex neurodevelopment disorder is kn...
Animals Autistic Disorder Calcium-Binding Proteins Cell Adhesion Molecules, Neuronal Cell Physiological Phenomena Gene Ontology Genome Genomics High-Throughput Nucleotide Sequencing Humans Membrane Potentials Mice Models, Molecular Nerve Tissue Proteins Neural Cell Adhesion Molecules Phenotype Rats Social Behavior Synapses Synaptic Potentials
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Development of 3D-QSAR Model for Acetylcholinesterase Inhibitors Using a Combination of Fingerprint, Molecular Docking, and Structure-Based Pharmacophore Approaches.

Toxicological sciences : an official journal of the Society of Toxicology 26202430
Acetylcholinesterase (AChE), a serine hydrolase vital for regulating the neurotransmitter acetylcholine in animals, has been used as a target for drugs and pesticides. With the increasing availability of AChE crystal structures, with or without ligan...
Acetylcholinesterase Animals Artificial Intelligence Binding Sites Catalytic Domain Cholinesterase Inhibitors Computational Biology Databases, Protein Expert Systems GPI-Linked Proteins Humans Imaging, Three-Dimensional Insecticides Ligands Models, Molecular Molecular Conformation Molecular Docking Simulation Nerve Tissue Proteins Nootropic Agents Peptide Mapping Quantitative Structure-Activity Relationship
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Impact of sub and supra-threshold adaptation currents in networks of spiking neurons.

Journal of computational neuroscience 26400658
Neuronal adaptation is the intrinsic capacity of the brain to change, by various mechanisms, its dynamical responses as a function of the context. Such a phenomena, widely observed in vivo and in vitro, is known to be crucial in homeostatic regulatio...
Action Potentials Adaptation, Physiological Animals Calcium Channels Cerebral Cortex Computer Simulation Humans Models, Neurological Nerve Net Nerve Tissue Proteins Neural Networks, Computer Neurons Nonlinear Dynamics Potassium Channels, Voltage-Gated Synapses
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