AIMC Topic: Neuropeptides

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Investigation of serum neuroserpin levels in pregnant women diagnosed with pre-eclampsia: a prospective case-control study.

BMC pregnancy and childbirth May 10, 2025
OBJECTIVE: Neuroserpin, a serine protease inhibitor, is recognized for its anti-inflammatory and neuroprotective properties. Given the central role of inflammation and neurological involvement in the pathophysiology of preeclampsia, this study aimed ...
Female Neuroserpin Young Adult Pre-Eclampsia Neuropeptides Adult Gestational Age Turkey Case-Control Studies Severity of Illness Index Biomarkers Serpins ROC Curve Humans Pregnancy Prospective Studies
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Machine learning-based rational design for efficient discovery of allatostatin analogs as promising lead candidates for novel IGRs.

Pest management science Nov 8, 2024
BACKGROUND: Insect neuropeptide allatostatins (ASTs) play a vital role in regulating insect growth, development, and reproduction, making them potential candidates for new insect growth regulators (IGRs). However, the practical use of natural ASTs in...
Juvenile Hormones Drug Design Machine Learning Drug Discovery Animals Structure-Activity Relationship Neuropeptides
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A novel framework based on explainable AI and genetic algorithms for designing neurological medicines.

Scientific reports Jun 4, 2024
The advent of the fourth industrial revolution, characterized by artificial intelligence (AI) as its central component, has resulted in the mechanization of numerous previously labor-intensive activities. The use of in silico tools has become prevale...
Algorithms Computer Simulation Deep Learning Neuropeptides Drug Design Humans Artificial Intelligence
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NeuroPpred-SVM: A New Model for Predicting Neuropeptides Based on Embeddings of BERT.

Journal of proteome research Feb 7, 2023
Neuropeptides play pivotal roles in different physiological processes and are related to different kinds of diseases. Identification of neuropeptides is of great benefit for studying the mechanism of these physiological processes and the treatment of...
Algorithms ROC Curve Support Vector Machine Area Under Curve Neuropeptides
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AI protein structure prediction-based modeling and mutagenesis of a protostome receptor and peptide ligands reveal key residues for their interaction.

The Journal of biological chemistry Aug 30, 2022
The protostome leucokinin (LK) signaling system, including LK peptides and their G protein-coupled receptors, has been characterized in several species. Despite the progress, molecular mechanisms governing LK peptide-receptor interactions remain to b...
Protein Conformation Mutagenesis Amides Ligands Neuropeptides Aplysia Animals Receptors, Neuropeptide Artificial Intelligence
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Identification of Synovial Fibroblast-Associated Neuropeptide Genes and m6A Factors in Rheumatoid Arthritis Using Single-Cell Analysis and Machine Learning.

Disease markers Feb 9, 2022
OBJECTIVES: Synovial fibroblasts (SFs) play an important role in the development and progression of rheumatoid arthritis (RA). However, the pathogenic mechanism of SFs remains unclear. The objective of this study was to investigate how neuropeptides ...
Adenosine Neuropeptides Synovial Membrane Fibroblasts Single-Cell Analysis Arthritis, Rheumatoid Humans Machine Learning
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Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features.

Journal of proteome research Aug 14, 2020
As hormones in the endocrine system and neurotransmitters in the immune system, neuropeptides (NPs) provide many opportunities for the discovery of new drugs and targets for nervous system disorders. In spite of their importance in the hormonal regul...
Algorithms Computational Biology Neuropeptides Machine Learning
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NeuroPIpred: a tool to predict, design and scan insect neuropeptides.

Scientific reports Mar 26, 2019
Insect neuropeptides and their associated receptors have been one of the potential targets for the pest control. The present study describes in silico models developed using natural and modified insect neuropeptides for predicting and designing new n...
Sequence Analysis, Protein Amino Acid Sequence Neuropeptides Humans Animals Software Support Vector Machine Databases, Protein
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NeuroScale: evolutional scale-based protein language models enable prediction of neuropeptides.

BMC biology May 28, 2025
BACKGROUND: Neuropeptides (NPs) are critical signaling molecules involved in various physiological and behavioral processes, including development, metabolism, and memory. They function within both the nervous and endocrine systems and have emerged a...
Neural Networks, Computer Neuropeptides
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NeuroPred-AIMP: Multimodal Deep Learning for Neuropeptide Prediction via Protein Language Modeling and Temporal Convolutional Networks.

Journal of chemical information and modeling May 12, 2025
Neuropeptides are key signaling molecules that regulate fundamental physiological processes ranging from metabolism to cognitive function. However, accurate identification is a huge challenge due to sequence heterogeneity, obscured functional motifs ...
Computational Biology Humans Neuropeptides Neural Networks, Computer Deep Learning
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