AIMC Topic: Polymerase Chain Reaction

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Developing a Machine Learning 'Smart' Polymerase Chain Reaction Thermocycler Part 2: Putting the Theoretical Framework into Practice.

Genes Sep 12, 2024
The introduction of PCR into forensic science and the rapid increases in the sensitivity, specificity and discrimination power of DNA profiling that followed have been fundamental in shaping the field of forensic biology. Despite these developments, ...
Polymerase Chain Reaction Forensic Genetics DNA DNA Fingerprinting Humans Machine Learning
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Developing a Machine-Learning 'Smart' PCR Thermocycler, Part 1: Construction of a Theoretical Framework.

Genes Sep 11, 2024
The use of PCR is widespread in biological fields. Some fields, such as forensic biology, push PCR to its limits as DNA profiling may be required in short timeframes, may be produced from minute amounts of starting material, and may be required to pe...
Machine Learning Polymerase Chain Reaction Humans
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Diagnosis model of early Pneumocystis jirovecii pneumonia based on convolutional neural network: a comparison with traditional PCR diagnostic method.

BMC pulmonary medicine Apr 25, 2024
BACKGROUND: Pneumocystis jirovecii pneumonia (PJP) is an interstitial pneumonia caused by pneumocystis jirovecii (PJ). The diagnosis of PJP primarily relies on the detection of the pathogen from lower respiratory tract specimens. However, it faces ch...
Neural Networks, Computer Tomography, X-Ray Computed Humans Adult Male Female Aged Pneumonia, Pneumocystis Early Diagnosis Middle Aged Pneumocystis carinii Polymerase Chain Reaction
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Advances in next-generation sequencing and emerging technologies for hematologic malignancies.

Haematologica Feb 1, 2024
Innovations in molecular diagnostics have often evolved through the study of hematologic malignancies. Examples include the pioneering characterization of the Philadelphia chromosome by cytogenetics in the 1970s, the implementation of polymerase chai...
Hematologic Neoplasms Mutation High-Throughput Nucleotide Sequencing Polymerase Chain Reaction Humans Artificial Intelligence
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Development of fecal microbial diagnostic marker sets of colorectal cancer using natural language processing method.

The International journal of biological markers Dec 21, 2023
BACKGROUND: Cancer screening and early detection greatly increase the chances of successful treatment. However, most cancer types lack effective early screening biomarkers. In recent years, natural language processing (NLP)-based text-mining methods ...
Polymerase Chain Reaction Biomarkers, Tumor Feces Early Detection of Cancer Natural Language Processing Humans Colorectal Neoplasms
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Deep-qGFP: A Generalist Deep Learning Assisted Pipeline for Accurate Quantification of Green Fluorescent Protein Labeled Biological Samples in Microreactors.

Small methods Nov 27, 2023
Absolute quantification of biological samples provides precise numerical expression levels, enhancing accuracy, and performance for rare templates. Current methodologies, however, face challenges-flow cytometers are costly and complex, whereas fluore...
Software Deep Learning Polymerase Chain Reaction Green Fluorescent Proteins Sepharose
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Novel plant disease detection techniques-a brief review.

Molecular biology reports Oct 12, 2023
Plant pathogens cause severe losses to agricultural yield worldwide. Tracking plant health and early disease detection is important to reduce the disease spread and thus economic loss. Though visual scouting has been practiced from former times, dete...
Plant Diseases Polymerase Chain Reaction Plants Artificial Intelligence
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A one-stage deep learning based method for automatic analysis of droplet-based digital PCR images.

The Analyst Jun 26, 2023
Droplet-based dPCR offers many advantages over chip-based dPCR, such as lower processing cost, higher droplet density, higher throughput, while requiring less sample. However, the stochastic nature of droplet locations, uneven illuminations, and uncl...
Algorithms Polymerase Chain Reaction Deep Learning Image Processing, Computer-Assisted
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Diagnosis of invasive fungal infections: challenges and recent developments.

Journal of biomedical science Jun 19, 2023
BACKGROUND: The global burden of invasive fungal infections (IFIs) has shown an upsurge in recent years due to the higher load of immunocompromised patients suffering from various diseases. The role of early and accurate diagnosis in the aggressive c...
Invasive Fungal Infections Humans Polymerase Chain Reaction Artificial Intelligence
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A deep learning based method for automatic analysis of high-throughput droplet digital PCR images.

The Analyst Jan 16, 2023
Droplet digital PCR (ddPCR) is a technique for absolute quantification of nucleic acid molecules and is widely used in biomedical research and clinical diagnosis. ddPCR partitions the reaction solution containing target molecules into a large number ...
Nucleic Acids Deep Learning Neural Networks, Computer Polymerase Chain Reaction Poisson Distribution
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