AIMC Topic: Prostheses and Implants

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Simultaneous spatiotemporal tracking and oxygen sensing of transient implants in vivo using hot-spot MRI and machine learning.

Proceedings of the National Academy of Sciences of the United States of America
A varying oxygen environment is known to affect cellular function in disease as well as activity of various therapeutics. For transient structures, whether they are unconstrained therapeutic transplants, migrating cells during tumor metastasis, or ce...

Classification and regression of spatio-temporal signals using NeuCube and its realization on SpiNNaker neuromorphic hardware.

Journal of neural engineering
OBJECTIVE: The objective of this work is to use the capability of spiking neural networks to capture the spatio-temporal information encoded in time-series signals and decode them without the use of hand-crafted features and vector-based learning and...

Unsupervised and real-time spike sorting chip for neural signal processing in hippocampal prosthesis.

Journal of neuroscience methods
BACKGROUND: Damage to the hippocampus will result in the loss of ability to form new long-term memories and cognitive disorders. At present, there is no effective medical treatment for this issue. Hippocampal cognitive prosthesis is proposed to repla...

CT image segmentation of bone for medical additive manufacturing using a convolutional neural network.

Computers in biology and medicine
BACKGROUND: The most tedious and time-consuming task in medical additive manufacturing (AM) is image segmentation. The aim of the present study was to develop and train a convolutional neural network (CNN) for bone segmentation in computed tomography...

Energy-Optimal Human Walking With Feedback-Controlled Robotic Prostheses: A Computational Study.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Lower-limb amputees typically experience reduced mobility and higher metabolic rates than non-amputees. It may be possible to improve their mobility and metabolic rate with an optimized robotic prosthesis. Here, we use large-scale trajectory optimiza...

Embodiment and Estrangement: Results from a First-in-Human "Intelligent BCI" Trial.

Science and engineering ethics
While new generations of implantable brain computer interface (BCI) devices are being developed, evidence in the literature about their impact on the patient experience is lagging. In this article, we address this knowledge gap by analysing data from...

Biarticular elements as a contributor to energy efficiency: biomechanical review and application in bio-inspired robotics.

Bioinspiration & biomimetics
Despite the increased interest in exoskeleton research in the last decades, not much progress has been made on the successful reduction of user effort. In humans, biarticular elements have been identified as one of the reasons for the energy economy ...

A reductionist approach to extract robust molecular markers from microarray data series - Isolating markers to track osseointegration.

Journal of biomedical informatics
Complexities in the full genome expression studies hinder the extraction of tracker genes to analyze the course of biological events. In this study, we demonstrate the applications of supervised machine learning methods to reduce the irrelevance in m...

Neural Data-Driven Musculoskeletal Modeling for Personalized Neurorehabilitation Technologies.

IEEE transactions on bio-medical engineering
OBJECTIVES: The development of neurorehabilitation technologies requires the profound understanding of the mechanisms underlying an individual's motor ability and impairment. A major factor limiting this understanding is the difficulty of bridging be...

Microrobotized blasting improves the bone-to-textured implant response. A preclinical in vivo biomechanical study.

Journal of the mechanical behavior of biomedical materials
This study evaluated the effect of microrobotized blasting of titanium endosteal implants relative to their manually blasted counterparts. Two different implant systems were utilized presenting two different implant surfaces. Control surfaces (Manual...