AIMC Topic: Receptors, GABA-A

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From neurotoxicity to neuroprotection: Rethinking GABAR-targeting anesthetics.

Cell biology and toxicology Jun 14, 2025
The brain growth spurt (BGS) represents a pivotal window in neurodevelopment, defined by rapid neurogenesis, heightened synaptogenesis, and the dynamic establishment of neural networks. During this phase, heightened brain plasticity significantly enh...
Brain-Derived Neurotrophic Factor Neuroprotective Agents Humans Animals Brain Oxidative Stress Neuroprotection Anesthetics Neurotoxicity Syndromes Receptors, GABA-A
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Network models incorporating chloride dynamics predict optimal strategies for terminating status epilepticus.

Neurobiology of disease May 20, 2025
Status epilepticus (SE), seizures lasting beyond five minutes, is a medical emergency commonly treated with benzodiazepines which enhance GABA receptor (GABAR) conductance. Despite widespread use, benzodiazepines fail in over one-third of patients, p...
Humans Neural Networks, Computer Action Potentials Electroencephalography Animals Models, Neurological Chlorides Receptors, GABA-A Nerve Net Status Epilepticus Anticonvulsants Benzodiazepines
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Application of Single-Nucleotide Polymorphisms in the Diagnosis of Autism Spectrum Disorders: A Preliminary Study with Artificial Neural Networks.

Journal of molecular neuroscience : MN Apr 1, 2019
Autism spectrum disorder (ASD) includes different neurodevelopmental disorders characterized by deficits in social communication, and restricted, repetitive patterns of behavior, interests or activities. Based on the importance of early diagnosis for...
Receptors, Metabotropic Glutamate Synaptosomal-Associated Protein 25 Child Polymorphism, Single Nucleotide Genetic Testing Receptors, GABA-A Male Deep Learning Sensitivity and Specificity Autism Spectrum Disorder Female Humans
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In Silico Prediction of Gamma-Aminobutyric Acid Type-A Receptors Using Novel Machine-Learning-Based SVM and GBDT Approaches.

BioMed research international Aug 8, 2016
Gamma-aminobutyric acid type-A receptors (GABAARs) belong to multisubunit membrane spanning ligand-gated ion channels (LGICs) which act as the principal mediators of rapid inhibitory synaptic transmission in the human brain. Therefore, the category p...
Models, Statistical Decision Trees Support Vector Machine Decision Making Brain Receptors, GABA-A Computer Simulation Ligands Machine Learning Reproducibility of Results Amino Acid Motifs Databases, Protein Algorithms Humans Computational Biology Amino Acids
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γ-Aminobutyric Acid Type A Receptor Potentiation Inhibits Learning in a Computational Network Model.

Anesthesiology Jul 1, 2018
BACKGROUND: Propofol produces memory impairment at concentrations well below those abolishing consciousness. Episodic memory, mediated by the hippocampus, is most sensitive. Two potentially overlapping scenarios may explain how γ-aminobutyric acid re...
Computer Simulation GABA-A Receptor Agonists Learning Memory Anesthetics, Intravenous Receptors, GABA-A Humans Propofol Hippocampus Neural Networks, Computer Neuronal Plasticity
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