AIMC Topic: Receptors, Glucocorticoid

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BGATT-GR: accurate identification of glucocorticoid receptor antagonists based on data augmentation combined with BiGRU-attention.

Scientific reports Jul 1, 2025
The glucocorticoid receptor (GR) is a critical nuclear receptor that regulates a broad spectrum of physiological functions, including stress adaptation, immune response, and metabolism. Given the association between aberrant GR signaling and various ...
Humans Drug Discovery Deep Learning Receptors, Glucocorticoid
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M3S-GRPred: a novel ensemble learning approach for the interpretable prediction of glucocorticoid receptor antagonists using a multi-step stacking strategy.

BMC bioinformatics Apr 30, 2025
Accelerating drug discovery for glucocorticoid receptor (GR)-related disorders, including innovative machine learning (ML)-based approaches, holds promise in advancing therapeutic development, optimizing treatment efficacy, and mitigating adverse eff...
Humans Machine Learning Algorithms Drug Discovery Computational Biology Ensemble Learning Receptors, Glucocorticoid
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Development of in silico classification models for binding affinity to the glucocorticoid receptor.

Chemosphere Jun 8, 2023
The endocrine disrupting properties of chemicals acting through the glucocorticoid receptor (GR) have attracted considerable interest. Since there are few data for most chemicals on their endocrine properties in silico approaches seem to be the most ...
Neural Networks, Computer Endocrine System Receptors, Glucocorticoid
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Utilization of machine learning for prediction of post-traumatic stress: a re-examination of cortisol in the prediction and pathways to non-remitting PTSD.

Translational psychiatry Mar 21, 2017
To date, studies of biological risk factors have revealed inconsistent relationships with subsequent post-traumatic stress disorder (PTSD). The inconsistent signal may reflect the use of data analytic tools that are ill equipped for modeling the comp...
Humans Machine Learning Algorithms Female Young Adult Adult Male Risk Assessment Stress Disorders, Post-Traumatic ROC Curve Support Vector Machine Longitudinal Studies Blood Pressure Area Under Curve Emergency Service, Hospital Norepinephrine Hydrocortisone Saliva Lymphocytes Heart Rate Adrenocorticotropic Hormone Linear Models Urine Wounds and Injuries Psychological Trauma Receptors, Glucocorticoid
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