AIMC Topic: Recombinant Proteins
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Clinical cure induced by pegylated interferon α-2b in the advantaged population of chronic hepatitis B virus infection: a retrospective cohort study.
Frontiers in cellular and infection microbiology
Jan 16, 2024
BACKGROUND: Among the advantaged population with clinical cure of chronic hepatitis B, chronic inactive hepatitis B virus carriers (IHCs) and nucleoside analog-experienced patients have similar serological manifestations. This study established non-i...
High-Yield Preparation of American Oyster Defensin (AOD) via a Small and Acidic Fusion Tag and Its Functional Characterization.
Marine drugs
Dec 20, 2023
The marine peptide, American oyster defensin (AOD), is derived from and exhibits a potent bactericidal effect. However, recombinant preparation has not been achieved due to the high charge and hydrophobicity. Although the traditional fusion tags suc...
Deep learning for optimization of protein expression.
Current opinion in biotechnology
Apr 21, 2023
Advances in high-throughput DNA synthesis and sequencing have fuelled the use of massively parallel reporter assays for strain characterization. These experiments produce large datasets that map DNA sequences to protein expression levels, and have sp...
Data-driven prediction models for forecasting multistep ahead profiles of mammalian cell culture toward bioprocess digital twins.
Biotechnology and bioengineering
Apr 20, 2023
Recently, the advancement in process analytical technology and artificial intelligence (AI) has enabled the generation of enormous culture data sets from biomanufacturing processes that produce various recombinant therapeutic proteins (RTPs), such as...
CPV of the Future: AI-Powered Continued Process Verification for Bioreactor Processes.
PDA journal of pharmaceutical science and technology
Sep 19, 2022
According to the standard guidelines by the FDA, process validation in biopharma manufacturing encompasses a life cycle consisting of three stages: process design (PD), process qualification (PQ), and continued process verification (CPV). The validit...
Reversing radiation-induced immunosuppression using a new therapeutic modality.
Life sciences in space research
May 11, 2022
Radiation-induced immune suppression poses significant health challenges for millions of patients undergoing cancer chemotherapy and radiotherapy treatment, and astronauts and space tourists travelling to outer space. While a limited number of recomb...
Stem-cell mobilization of healthy sibling donors with pegfilgrastim-A prospective open-label phase II trial (EudraCT no: 2005-004971-39).
Transfusion
Dec 10, 2021
BACKGROUND: Pegfilgrastim is a covalently bound conjugate of filgrastim and mono-methoxypolyethylene glycol with a longer half-life.
Deep protein representations enable recombinant protein expression prediction.
Computational biology and chemistry
Oct 27, 2021
A crucial process in the production of industrial enzymes is recombinant gene expression, which aims to induce enzyme overexpression of the genes in a host microbe. Current approaches for securing overexpression rely on molecular tools such as adjust...
Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity.
Nature communications
Jun 10, 2021
In systemic light chain amyloidosis (AL), pathogenic monoclonal immunoglobulin light chains (LC) form toxic aggregates and amyloid fibrils in target organs. Prompt diagnosis is crucial to avoid permanent organ damage, but delayed diagnosis is common ...
Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning.
Journal of the American Chemical Society
Mar 8, 2021
Macrocycles, including macrocyclic peptides, have shown promise for targeting challenging protein-protein interactions (PPIs). One PPI of high interest is between Kelch-like ECH-Associated Protein-1 (KEAP1) and Nuclear Factor (Erythroid-derived 2)-li...
Humans
Nuclear Magnetic Resonance, Biomolecular
Machine Learning
NF-E2-Related Factor 2
Peptides
Crystallography, X-Ray
Protein Binding
Mutagenesis, Site-Directed
Amino Acid Motifs
Hydrogen Bonding
Cyclization
Recombinant Proteins
Fluorescence Polarization
Kelch-Like ECH-Associated Protein 1
Structure-Activity Relationship
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