AIMC Topic: RNA, Circular

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GATNNCDA: A Method Based on Graph Attention Network and Multi-Layer Neural Network for Predicting circRNA-Disease Associations.

International journal of molecular sciences Aug 7, 2021
Circular RNAs (circRNAs) are a new class of endogenous non-coding RNAs with covalent closed loop structure. Researchers have revealed that circRNAs play an important role in human diseases. As experimental identification of interactions between circR...
Humans Neural Networks, Computer Computational Biology Databases, Nucleic Acid RNA, Circular RNA, Neoplasm Liver Neoplasms Carcinoma, Hepatocellular Female Breast Neoplasms
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Deep Matrix Factorization Improves Prediction of Human CircRNA-Disease Associations.

IEEE journal of biomedical and health informatics Mar 5, 2021
In recent years, more and more evidence indicates that circular RNAs (circRNAs) with covalently closed loop play various roles in biological processes. Dysregulation and mutation of circRNAs may be implicated in diseases. Due to its stable structure ...
RNA, Circular Forecasting Research Design Humans Neural Networks, Computer
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PCirc: random forest-based plant circRNA identification software.

BMC bioinformatics Jan 6, 2021
BACKGROUND: Circular RNA (circRNA) is a novel type of RNA with a closed-loop structure. Increasing numbers of circRNAs are being identified in plants and animals, and recent studies have shown that circRNAs play an important role in gene regulation. ...
RNA, Circular Computational Biology Plants Machine Learning Software
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DeepciRGO: functional prediction of circular RNAs through hierarchical deep neural networks using heterogeneous network features.

BMC bioinformatics Nov 12, 2020
BACKGROUND: Circular RNAs (circRNAs) are special noncoding RNA molecules with closed loop structures. Compared with the traditional linear RNA, circRNA is more stable and not easily degraded. Many studies have shown that circRNAs are involved in the ...
Ubiquitin-Protein Ligases Gene Ontology RNA, Circular Cell Movement Genetic Loci Cell Proliferation DNA Helicases Humans Cell Line, Tumor Protein Interaction Maps Neural Networks, Computer
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An ensemble approach for CircRNA-disease association prediction based on autoencoder and deep neural network.

Gene Aug 7, 2020
Circular RNAs (circRNA) are a special kind of covalently closed single-stranded RNA molecules. They have been shown to control and coordinate various biological processes. Recent researches show that circRNAs are closely associated with numerous chro...
RNA, Circular Genome-Wide Association Study Genomics Genetic Predisposition to Disease Humans Deep Learning
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Matrix factorization with neural network for predicting circRNA-RBP interactions.

BMC bioinformatics Jun 5, 2020
BACKGROUND: Circular RNA (circRNA) has been extensively identified in cells and tissues, and plays crucial roles in human diseases and biological processes. circRNA could act as dynamic scaffolding molecules that modulate protein-protein interactions...
Cell Line, Tumor ROC Curve Area Under Curve RNA, Circular RNA-Binding Proteins Databases, Factual Neoplasms Humans Neural Networks, Computer
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Identifying Cancer-Specific circRNA-RBP Binding Sites Based on Deep Learning.

Molecules (Basel, Switzerland) Nov 7, 2019
Circular RNAs (circRNAs) are extensively expressed in cells and tissues, and play crucial roles in human diseases and biological processes. Recent studies have reported that circRNAs could function as RNA binding protein (RBP) sponges, meanwhile RBPs...
RNA-Binding Proteins Databases, Protein Neoplasms Deep Learning Sequence Analysis, Protein RNA, Neoplasm Humans RNA, Circular Neoplasm Proteins Binding Sites
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Computational Prediction of Human Disease- Associated circRNAs Based on Manifold Regularization Learning Framework.

IEEE journal of biomedical and health informatics Jan 9, 2019
The accumulating evidences regarding circular RNAs (circRNAs) indicate that they play crucial roles in a wide range of biological processes and participate in tumorigenesis and progression. The number of newly discovered circRNAs have increased drama...
Computational Biology Area Under Curve RNA, Circular Algorithms Coronary Artery Disease Neoplasms Humans Machine Learning
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CR-deal: Explainable Neural Network for circRNA-RBP Binding Site Recognition and Interpretation.

Interdisciplinary sciences, computational life sciences Jun 1, 2025
circRNAs are a type of single-stranded non-coding RNA molecules, and their unique feature is their closed circular structure. The interaction between circRNAs and RNA-binding proteins (RBPs) plays a key role in biological functions and is crucial for...
Humans Neural Networks, Computer RNA-Binding Proteins Binding Sites RNA, Circular Deep Learning Computational Biology
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Interpretable multi-instance heterogeneous graph network learning modelling CircRNA-drug sensitivity association prediction.

BMC biology May 14, 2025
BACKGROUND: Different expression levels of circular RNAs (circRNAs) affect the sensitivity of human cells to drugs, thus producing different responses to the therapeutic effects of drugs. Using traditional biomedical experiments to discover and confi...
RNA, Circular Neural Networks, Computer Machine Learning Humans
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