AIMC Topic: RNA, Circular

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Prediction of circRNA-Disease Associations Based on the Combination of Multi-Head Graph Attention Network and Graph Convolutional Network.

Biomolecules Jul 2, 2022
Circular RNAs (circRNAs) are covalently closed single-stranded RNA molecules, which have many biological functions. Previous experiments have shown that circRNAs are involved in numerous biological processes, especially regulatory functions. It has a...
Humans Computational Biology RNA RNA, Circular Neural Networks, Computer Algorithms
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CRBPDL: Identification of circRNA-RBP interaction sites using an ensemble neural network approach.

PLoS computational biology Jan 20, 2022
Circular RNAs (circRNAs) are non-coding RNAs with a special circular structure produced formed by the reverse splicing mechanism. Increasing evidence shows that circular RNAs can directly bind to RNA-binding proteins (RBP) and play an important role ...
RNA Splicing RNA, Circular Models, Biological Binding Sites Machine Learning Algorithms Neural Networks, Computer Computational Biology Animals RNA-Binding Proteins
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GATNNCDA: A Method Based on Graph Attention Network and Multi-Layer Neural Network for Predicting circRNA-Disease Associations.

International journal of molecular sciences Aug 7, 2021
Circular RNAs (circRNAs) are a new class of endogenous non-coding RNAs with covalent closed loop structure. Researchers have revealed that circRNAs play an important role in human diseases. As experimental identification of interactions between circR...
Humans Breast Neoplasms Liver Neoplasms Carcinoma, Hepatocellular Neural Networks, Computer Female RNA, Neoplasm Computational Biology RNA, Circular Databases, Nucleic Acid
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Deep Matrix Factorization Improves Prediction of Human CircRNA-Disease Associations.

IEEE journal of biomedical and health informatics Mar 5, 2021
In recent years, more and more evidence indicates that circular RNAs (circRNAs) with covalently closed loop play various roles in biological processes. Dysregulation and mutation of circRNAs may be implicated in diseases. Due to its stable structure ...
Research Design RNA, Circular Neural Networks, Computer Forecasting Humans
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PCirc: random forest-based plant circRNA identification software.

BMC bioinformatics Jan 6, 2021
BACKGROUND: Circular RNA (circRNA) is a novel type of RNA with a closed-loop structure. Increasing numbers of circRNAs are being identified in plants and animals, and recent studies have shown that circRNAs play an important role in gene regulation. ...
Software Computational Biology RNA, Circular Plants Machine Learning
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DeepciRGO: functional prediction of circular RNAs through hierarchical deep neural networks using heterogeneous network features.

BMC bioinformatics Nov 12, 2020
BACKGROUND: Circular RNAs (circRNAs) are special noncoding RNA molecules with closed loop structures. Compared with the traditional linear RNA, circRNA is more stable and not easily degraded. Many studies have shown that circRNAs are involved in the ...
Gene Ontology Genetic Loci RNA, Circular Ubiquitin-Protein Ligases Cell Line, Tumor DNA Helicases Humans Protein Interaction Maps Cell Movement Neural Networks, Computer Cell Proliferation
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An ensemble approach for CircRNA-disease association prediction based on autoencoder and deep neural network.

Gene Aug 7, 2020
Circular RNAs (circRNA) are a special kind of covalently closed single-stranded RNA molecules. They have been shown to control and coordinate various biological processes. Recent researches show that circRNAs are closely associated with numerous chro...
Deep Learning Genome-Wide Association Study Humans Genomics RNA, Circular Genetic Predisposition to Disease
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Matrix factorization with neural network for predicting circRNA-RBP interactions.

BMC bioinformatics Jun 5, 2020
BACKGROUND: Circular RNA (circRNA) has been extensively identified in cells and tissues, and plays crucial roles in human diseases and biological processes. circRNA could act as dynamic scaffolding molecules that modulate protein-protein interactions...
Area Under Curve RNA, Circular Cell Line, Tumor ROC Curve RNA-Binding Proteins Humans Neural Networks, Computer Databases, Factual Neoplasms
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Identifying Cancer-Specific circRNA-RBP Binding Sites Based on Deep Learning.

Molecules (Basel, Switzerland) Nov 7, 2019
Circular RNAs (circRNAs) are extensively expressed in cells and tissues, and play crucial roles in human diseases and biological processes. Recent studies have reported that circRNAs could function as RNA binding protein (RBP) sponges, meanwhile RBPs...
Databases, Protein Humans Neoplasm Proteins RNA, Circular Binding Sites Deep Learning Neoplasms Sequence Analysis, Protein RNA-Binding Proteins RNA, Neoplasm
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Computational Prediction of Human Disease- Associated circRNAs Based on Manifold Regularization Learning Framework.

IEEE journal of biomedical and health informatics Jan 9, 2019
The accumulating evidences regarding circular RNAs (circRNAs) indicate that they play crucial roles in a wide range of biological processes and participate in tumorigenesis and progression. The number of newly discovered circRNAs have increased drama...
Area Under Curve Coronary Artery Disease Humans Algorithms Neoplasms Machine Learning RNA, Circular Computational Biology
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