AIMC Topic: RNA, Circular
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Combined bioinformatics and machine learning methodologies reveal prognosis-related ceRNA network and propose ABCA8, CAT, and CXCL12 as independent protective factors against osteosarcoma.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Aug 1, 2024
BACKGROUND: Aberrant circular RNA (circRNA) acts as an oncogene or suppressor during neoplasm initiation and development. However, the functions of most circRNAs in osteosarcoma (OS) remain unclear.
Humans
MicroRNAs
Chemokine CXCL12
Osteosarcoma
Bone Neoplasms
Protective Factors
RNA, Competitive Endogenous
ATP-Binding Cassette Transporters
RNA, Circular
Gene Regulatory Networks
Computational Biology
RNA, Messenger
Gene Expression Regulation, Neoplastic
Machine Learning
Prognosis
Biomarkers, Tumor
THGNCDA: circRNA-disease association prediction based on triple heterogeneous graph network.
Briefings in functional genomics
Jul 19, 2024
Circular RNAs (circRNAs) are a class of noncoding RNA molecules featuring a closed circular structure. They have been proved to play a significant role in the reduction of many diseases. Besides, many researches in clinical diagnosis and treatment of...
Identification of circRNA-disease associations via multi-model fusion and ensemble learning.
Journal of cellular and molecular medicine
Apr 1, 2024
Circular RNA (circRNA) is a common non-coding RNA and plays an important role in the diagnosis and therapy of human diseases, circRNA-disease associations prediction based on computational methods can provide a new way for better clinical diagnosis. ...
BioKA: a curated and integrated biomarker knowledgebase for animals.
Nucleic acids research
Jan 5, 2024
Biomarkers play an important role in various area such as personalized medicine, drug development, clinical care, and molecule breeding. However, existing animals' biomarker resources predominantly focus on human diseases, leaving a significant gap i...
MLNGCF: circRNA-disease associations prediction with multilayer attention neural graph-based collaborative filtering.
Bioinformatics (Oxford, England)
Aug 1, 2023
MOTIVATION: CircRNAs play a critical regulatory role in physiological processes, and the abnormal expression of circRNAs can mediate the processes of diseases. Therefore, exploring circRNAs-disease associations is gradually becoming an important area...
MPCLCDA: predicting circRNA-disease associations by using automatically selected meta-path and contrastive learning.
Briefings in bioinformatics
Jul 20, 2023
Circular RNA (circRNA) is closely associated with human diseases. Accordingly, identifying the associations between human diseases and circRNA can help in disease prevention, diagnosis and treatment. Traditional methods are time consuming and laborio...
Collaborative deep learning improves disease-related circRNA prediction based on multi-source functional information.
Briefings in bioinformatics
Mar 19, 2023
Emerging studies have shown that circular RNAs (circRNAs) are involved in a variety of biological processes and play a key role in disease diagnosing, treating and inferring. Although many methods, including traditional machine learning and deep lear...
MNMDCDA: prediction of circRNA-disease associations by learning mixed neighborhood information from multiple distances.
Briefings in bioinformatics
Nov 19, 2022
Emerging evidence suggests that circular RNA (circRNA) is an important regulator of a variety of pathological processes and serves as a promising biomarker for many complex human diseases. Nevertheless, there are relatively few known circRNA-disease ...
Deep learning models for disease-associated circRNA prediction: a review.
Briefings in bioinformatics
Nov 19, 2022
Emerging evidence indicates that circular RNAs (circRNAs) can provide new insights and potential therapeutic targets for disease diagnosis and treatment. However, traditional biological experiments are expensive and time-consuming. Recently, deep lea...
A machine learning framework based on multi-source feature fusion for circRNA-disease association prediction.
Briefings in bioinformatics
Sep 20, 2022
Circular RNAs (circRNAs) are involved in the regulatory mechanisms of multiple complex diseases, and the identification of their associations is critical to the diagnosis and treatment of diseases. In recent years, many computational methods have bee...
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