MOTIVATION: MicroRNAs (miRNAs) are one class of small noncoding RNA molecules, which regulate gene expression at the post-transcriptional level and play important roles in health and disease. To dissect the critical miRNAs in miRNAome, it is needed t...
Journal of the American Medical Informatics Association : JAMIA
Mar 1, 2019
OBJECTIVE: We aim to deliver a framework with 2 main objectives: 1) facilitating the design of theory-driven, adaptive, digital interventions addressing chronic illnesses or health problems and 2) producing personalized intervention delivery strategi...
MOTIVATION: A major component in increasing our understanding of the biology of an organism is the mapping of its genotypic potential into its phenotypic expression profiles. This mapping is executed by the machinery of gene regulation, which is esse...
Physical chemistry chemical physics : PCCP
Feb 27, 2019
We establish a comprehensive quantitative structure-activity relationship (QSAR) model termed AlphaQ through the machine learning algorithm to associate the fully quantum mechanical molecular descriptors with various biochemical and pharmacological p...
Mathematical biosciences and engineering : MBE
Feb 20, 2019
For discovery of new usage of drugs, the function type of their target genes plays an important role, and the hypothesis of "Antagonist-GOF" and "Agonist-LOF" has laid a solid foundation for supporting drug repurposing. In this research, an active ge...
Mathematical biosciences and engineering : MBE
Feb 20, 2019
Deep learning tools have been a new way for privacy attacks on remote sensing images. However, since labeled data of privacy objects in remote sensing images are less, the samples for training are commonly small. Besides, traditional deep neural netw...
Mathematical biosciences and engineering : MBE
Feb 19, 2019
The Hough transform has been widely used in image analysis and digital image processing due to its capability of transforming image space detection to parameter space accumulation. In this paper, we propose a novel Angle-Aided Circle Detection (AACD)...
Mathematical biosciences and engineering : MBE
Feb 18, 2019
Particle swarm optimizer was proposed in 1995, and since then, it has become an extremely popular swarm intelligent algorithm with widespread applications. Many modified versions of it have been developed, in which, comprehensive learning particle sw...
MOTIVATION: N4-methylcytosine (4mC), an important epigenetic modification formed by the action of specific methyltransferases, plays an essential role in DNA repair, expression and replication. The accurate identification of 4mC sites aids in-depth r...
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