AIMC Topic: Interleukin-2

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In Silico tool for predicting, designing and scanning IL-2 inducing peptides.

Scientific reports Jul 16, 2025
Interleukin-2 (IL-2) based immunotherapy has been approved for treating certain types of cancer, as IL-2 plays a crucial role in regulating the immune system. In this study, we developed a method for predicting IL-2-inducing peptides. Our method was ...
Humans Machine Learning Deep Learning Computational Biology Interleukin-2 Computer Simulation Peptides
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Identification of hub genes and immune-related pathways in acute myeloid leukemia: insights from bioinformatics and experimental validation.

Frontiers in immunology Jan 10, 2025
BACKGROUND: This study aims to identify the hub genes and immune-related pathways in acute myeloid leukemia (AML) to provide new theories for immunotherapy.
Signal Transduction Interleukin-2 Gene Regulatory Networks Humans Computational Biology Leukemia, Myeloid, Acute
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Predicting cryptic ligand binding sites based on normal modes guided conformational sampling.

Proteins Dec 5, 2020
To greatly expand the druggable genome, fast and accurate predictions of cryptic sites for small molecules binding in target proteins are in high demand. In this study, we have developed a fast and simple conformational sampling scheme guided by norm...
Antigens, Neoplasm Interleukin-2 ROC Curve Computational Biology Area Under Curve Antigens, CD Molecular Dynamics Simulation Models, Statistical Regression Analysis Machine Learning Algorithms Reproducibility of Results SARS-CoV-2 Humans Protein Tyrosine Phosphatase, Non-Receptor Type 1 Exportin 1 Protein Elasticity Receptors, Cytoplasmic and Nuclear Protein Conformation Binding Sites Hepacivirus Ligands Coronavirus 3C Proteases Coronavirus Papain-Like Proteases Karyopherins
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GOF/LOF knowledge inference with tensor decomposition in support of high order link discovery for gene, mutation and disease.

Mathematical biosciences and engineering : MBE Feb 20, 2019
For discovery of new usage of drugs, the function type of their target genes plays an important role, and the hypothesis of "Antagonist-GOF" and "Agonist-LOF" has laid a solid foundation for supporting drug repurposing. In this research, an active ge...
Interleukin-2 Receptor alpha Subunit Molecular Sequence Annotation Genetic Diseases, Inborn Humans Drug Repositioning Interleukin-2 Cost-Benefit Analysis Machine Learning Mutation Lymphoma Myelodysplastic Syndromes Software Algorithms Genetic Variation Recombinant Proteins Models, Genetic
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Effects of extracts from Chuanwu (Aconitum Carmichaelii) and Banxia (Rhizoma Pinelliae) on excisional wound healing in a rat's model.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Feb 1, 2019
OBJEVTIVE: To investigate the effects of extracts from Chuanwu (Aconitum Carmichaelii) and Banxia (Rhizoma Pinelliae) on the excisional wound healing in a rat's model.
Real-Time Polymerase Chain Reaction Wound Healing Interleukin-10 Fibroblast Growth Factor 2 Rats Tumor Necrosis Factor-alpha Disease Models, Animal Interleukin-4 Pinellia Drugs, Chinese Herbal Transforming Growth Factor beta1 Animals Aconitum Interleukin-2 Rats, Sprague-Dawley
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