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Interleukin-2

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Identification of hub genes and immune-related pathways in acute myeloid leukemia: insights from bioinformatics and experimental validation.

Frontiers in immunology 39867885
BACKGROUND: This study aims to identify the hub genes and immune-related pathways in acute myeloid leukemia (AML) to provide new theories for immunotherapy.
Computational Biology Gene Regulatory Networks Humans Interleukin-2 Leukemia, Myeloid, Acute Signal Transduction
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Effects of extracts from Chuanwu (Aconitum Carmichaelii) and Banxia (Rhizoma Pinelliae) on excisional wound healing in a rat's model.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 32186025
OBJEVTIVE: To investigate the effects of extracts from Chuanwu (Aconitum Carmichaelii) and Banxia (Rhizoma Pinelliae) on the excisional wound healing in a rat's model.
Aconitum Animals Disease Models, Animal Drugs, Chinese Herbal Fibroblast Growth Factor 2 Interleukin-10 Interleukin-2 Interleukin-4 Pinellia Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Transforming Growth Factor beta1 Tumor Necrosis Factor-alpha Wound Healing
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GOF/LOF knowledge inference with tensor decomposition in support of high order link discovery for gene, mutation and disease.

Mathematical biosciences and engineering : MBE 30947425
For discovery of new usage of drugs, the function type of their target genes plays an important role, and the hypothesis of "Antagonist-GOF" and "Agonist-LOF" has laid a solid foundation for supporting drug repurposing. In this research, an active ge...
Algorithms Cost-Benefit Analysis Drug Repositioning Genetic Diseases, Inborn Genetic Variation Humans Interleukin-2 Interleukin-2 Receptor alpha Subunit Lymphoma Machine Learning Models, Genetic Molecular Sequence Annotation Mutation Myelodysplastic Syndromes Recombinant Proteins Software
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Predicting cryptic ligand binding sites based on normal modes guided conformational sampling.

Proteins 33244830
To greatly expand the druggable genome, fast and accurate predictions of cryptic sites for small molecules binding in target proteins are in high demand. In this study, we have developed a fast and simple conformational sampling scheme guided by norm...
Algorithms Antigens, CD Antigens, Neoplasm Area Under Curve Binding Sites Computational Biology Coronavirus 3C Proteases Coronavirus Papain-Like Proteases Elasticity Exportin 1 Protein Hepacivirus Humans Interleukin-2 Karyopherins Ligands Machine Learning Models, Statistical Molecular Dynamics Simulation Protein Conformation Protein Tyrosine Phosphatase, Non-Receptor Type 1 Receptors, Cytoplasmic and Nuclear Regression Analysis Reproducibility of Results ROC Curve SARS-CoV-2
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