AIMC Topic: Interleukin-2

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Identification of hub genes and immune-related pathways in acute myeloid leukemia: insights from bioinformatics and experimental validation.

Frontiers in immunology Jan 10, 2025
BACKGROUND: This study aims to identify the hub genes and immune-related pathways in acute myeloid leukemia (AML) to provide new theories for immunotherapy.
Interleukin-2 Humans Leukemia, Myeloid, Acute Gene Regulatory Networks Computational Biology Signal Transduction
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Predicting cryptic ligand binding sites based on normal modes guided conformational sampling.

Proteins Dec 5, 2020
To greatly expand the druggable genome, fast and accurate predictions of cryptic sites for small molecules binding in target proteins are in high demand. In this study, we have developed a fast and simple conformational sampling scheme guided by norm...
Reproducibility of Results SARS-CoV-2 Machine Learning Algorithms Antigens, Neoplasm Interleukin-2 ROC Curve Computational Biology Binding Sites Coronavirus 3C Proteases Protein Conformation Receptors, Cytoplasmic and Nuclear Protein Tyrosine Phosphatase, Non-Receptor Type 1 Humans Exportin 1 Protein Coronavirus Papain-Like Proteases Karyopherins Molecular Dynamics Simulation Hepacivirus Ligands Elasticity Area Under Curve Models, Statistical Antigens, CD Regression Analysis
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GOF/LOF knowledge inference with tensor decomposition in support of high order link discovery for gene, mutation and disease.

Mathematical biosciences and engineering : MBE Feb 20, 2019
For discovery of new usage of drugs, the function type of their target genes plays an important role, and the hypothesis of "Antagonist-GOF" and "Agonist-LOF" has laid a solid foundation for supporting drug repurposing. In this research, an active ge...
Molecular Sequence Annotation Genetic Diseases, Inborn Interleukin-2 Receptor alpha Subunit Cost-Benefit Analysis Myelodysplastic Syndromes Genetic Variation Humans Machine Learning Interleukin-2 Recombinant Proteins Software Drug Repositioning Lymphoma Models, Genetic Algorithms Mutation
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Effects of extracts from Chuanwu (Aconitum Carmichaelii) and Banxia (Rhizoma Pinelliae) on excisional wound healing in a rat's model.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Feb 1, 2019
OBJEVTIVE: To investigate the effects of extracts from Chuanwu (Aconitum Carmichaelii) and Banxia (Rhizoma Pinelliae) on the excisional wound healing in a rat's model.
Fibroblast Growth Factor 2 Pinellia Transforming Growth Factor beta1 Aconitum Disease Models, Animal Animals Drugs, Chinese Herbal Real-Time Polymerase Chain Reaction Rats, Sprague-Dawley Tumor Necrosis Factor-alpha Interleukin-10 Wound Healing Rats Interleukin-4 Interleukin-2
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