AIMC Topic: Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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Cutaneous squamous cell carcinoma characterized by MALDI mass spectrometry imaging in combination with machine learning.

Scientific reports
Cutaneous squamous cell carcinoma (SCC) is an increasingly prevalent global health concern. Current diagnostic and surgical methods are reliable, but they require considerable resources and do not provide metabolomic insight. Matrix-assisted laser de...

Predicting the age of field mosquitoes using mass spectrometry and deep learning.

Science advances
Mosquito-borne diseases like malaria are rising globally, and improved mosquito vector surveillance is needed. Survival of mosquitoes is key for epidemiological monitoring of malaria transmission and evaluation of vector control strategies targeting...

Application of MALDI-TOF MS and machine learning for the detection of SARS-CoV-2 and non-SARS-CoV-2 respiratory infections.

Microbiology spectrum
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) could aid the diagnosis of acute respiratory infections (ARIs) owing to its affordability and high-throughput capacity. MALDI-TOF MS has been proposed for use...

A Machine Learning-Driven Comparison of Ion Images Obtained by MALDI and MALDI-2 Mass Spectrometry Imaging.

Journal of the American Society for Mass Spectrometry
Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) enables label-free imaging of biomolecules in biological tissues. However, many species remain undetected due to their poor ionization efficiencies. MALDI-2 (laser-indu...

Multiscale biochemical mapping of the brain through deep-learning-enhanced high-throughput mass spectrometry.

Nature methods
Spatial omics technologies can reveal the molecular intricacy of the brain. While mass spectrometry imaging (MSI) provides spatial localization of compounds, comprehensive biochemical profiling at a brain-wide scale in three dimensions by MSI with si...

Protein profile pattern analysis: A multifarious, in vitro diagnosis technique for universal screening.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Universal health care is attracting increased attention nowadays, because of the large increase in population all over the world, and a similar increase in life expectancy, leading to an increase in the incidence of non-communicable (various cancers,...

Workflow for Evaluating Normalization Tools for Omics Data Using Supervised and Unsupervised Machine Learning.

Journal of the American Society for Mass Spectrometry
To achieve high quality omics results, systematic variability in mass spectrometry (MS) data must be adequately addressed. Effective data normalization is essential for minimizing this variability. The abundance of approaches and the data-dependent n...

Rapid identification of Salmonella serovars Enteritidis and Typhimurium using whole cell matrix assisted laser desorption ionization - Time of flight mass spectrometry (MALDI-TOF MS) coupled with multivariate analysis and artificial intelligence.

Journal of microbiological methods
Salmonella is a common food-borne pathogen with Enteritidis and Typhimurium being among the most important serovars causing numerous outbreaks. A rapid method was investigated to identify these serovars using whole-cell MALDI-TOF MS coupled with mult...

Rapid Discrimination of ST175 Isolates Involved in a Nosocomial Outbreak Using MALDI-TOF Mass Spectrometry and FTIR Spectroscopy Coupled with Machine Learning.

Transboundary and emerging diseases
The goal of this study was to evaluate matrix-assisted laser desorption ionization-iime of flight mass spectrometry (MALDI-TOF MS) and Fourier-transform infrared spectroscopy (FTIR-S) as diagnostic alternatives to DNA-based methods for the detection ...

Urine and serum metabolic profiling combined with machine learning for autoimmune disease discrimination and classification.

Chemical communications (Cambridge, England)
Precision diagnosis and classification of autoimmune diseases (ADs) is challenging due to the obscure symptoms and pathological causes. Biofluid metabolic analysis has the potential for disease screening, in which high throughput, rapid analysis and ...