Recently, pharmaceutical cocrystal technology has garnered considerable global attention because of its innovativeness and environmental sustainability. This technology effectively enhances the bioavailability of poorly soluble drugs and optimizes th...
International journal of pharmaceutics
Dec 8, 2025
Driven by the Food and Drug Administration's Quality-by-Design initiative and the advancements of Industry 4.0, the pharmaceutical industry is transitioning from traditional batch manufacturing to advanced manufacturing. This transition requires resh...
International journal of pharmaceutics
Nov 24, 2025
Over the past two decades, a diverse array of ultrasonic and acoustic elastic-wave techniques has been developed to non-destructively assess macro- and micro-scale properties of compressed Oral Solid Dosage (OSD) forms. These methods are increasingly...
International journal of pharmaceutics
Nov 16, 2025
Pharmaceutical 3D printing is an emerging digital manufacturing technology capable of autonomously producing personalised medicines. However, the same reliance on digital workflows that enables this innovation also introduces new vulnerabilities, mos...
International journal of pharmaceutics
Nov 15, 2025
Transdermal drug delivery systems (TDDS) offer a painless and non-invasive route of administration but are limited by the skin barrier. Microneedles (MNs) have been shown to overcome this challenge and enable the delivery of small molecules, peptides...
International journal of pharmaceutics
Oct 27, 2025
Assessing the feasibility of a manufacturing route for a given formulation and process is a key initial step in drug product development. Additionally, the final product must meet a series of critical quality attributes to be considered suitable to m...
International journal of pharmaceutics
Oct 4, 2025
The transition from traditional batch to continuous pharmaceutical manufacturing puts additional demands on the efficient process development and operation. The comprehensive understanding of complex interdependencies between critical process paramet...
Poor oral bioavailability in most modern pharmaceuticals is primarily caused by poor aqueous solubility. Most NCEs (New Chemical Entities) and nearly 40% of drugs on the market fall into either Biopharmaceutical Classification System (BCS) class II o...
International journal of pharmaceutics
Sep 19, 2025
Ribbon splitting, a phenomenon that can occur during the roller compaction operation used in dry granulation processes, can lead to compromised granule uniformity, poor tabletability, and ultimately, off-specification tablet production. Despite its i...
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Jun 21, 2025
The application of artificial neural networks (ANNs) has the potential to fundamentally change the pharmaceutical industry, making manufacturing more agile, robust, efficient and reliable. Although ANNs' application as data-driven soft sensors has a ...
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