AIMC Topic: Transdermal Patch

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Artificial intelligence-driven hydrogel microneedle patches integrating 5-fluorouracil inclusion complex-loaded flexible pegylated liposomes for enhanced non-melanoma skin cancer treatment.

International journal of pharmaceutics Dec 13, 2024
The current study focused on the development of crosslinked hydrogel microneedle patches (cHMNs) incorporating 5-FU-hydroxypropyl beta-cyclodextrin inclusion complex-loaded flexible PEGylated liposomes (5-FU-HPβCD-loaded FP-LPs) to enhance treatment ...
Humans Artificial Intelligence Administration, Cutaneous Needles Hydrogels Liposomes Skin Absorption Transdermal Patch Antimetabolites, Antineoplastic 2-Hydroxypropyl-beta-cyclodextrin Mice Skin Fluorouracil Polyethylene Glycols Animals Cell Line, Tumor Skin Neoplasms Drug Delivery Systems
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Development and comparison of machine learning models for in-vitro drug permeation prediction from microneedle patch.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V May 6, 2024
The field of machine learning (ML) is advancing to a larger extent and finding its applications across numerous fields. ML has the potential to optimize the development process of microneedle patch by predicting the drug release pattern prior to its ...
Needles Skin Absorption Drug Liberation Administration, Cutaneous Microinjections Transdermal Patch Drug Delivery Systems Animals Skin Permeability Neural Networks, Computer Machine Learning
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Biphasic burst and sustained transdermal delivery in vivo using an AI-optimized 3D-printed MN patch.

International journal of pharmaceutics Feb 6, 2023
The objective of the present study was to fabricate microneedles for delivering lipophilic active ingredients (APIs) using digital light processing (DLP) printing technology and quality by design (QbD) supplemented by artificial intelligence (AI) alg...
Transdermal Patch Humans Artificial Intelligence Drug Delivery Systems Pharmaceutical Preparations Administration, Cutaneous Needles Ibuprofen Printing, Three-Dimensional Skin Animals Rats
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Lidocaine 5% Patch for Treatment of Acute Pain After Robotic Cardiac Surgery and Prevention of Persistent Incisional Pain: A Randomized, Placebo-Controlled, Double-Blind Trial.

Pain medicine (Malden, Mass.) Jul 14, 2015
OBJECTIVES: To test the hypotheses that lidocaine 5% patches decrease the severity of acute pain and incidence of persistent incisional pain after robotic cardiac valve surgery.
Transdermal Patch Disability Evaluation Heart Valves Acute Pain Patient Satisfaction Double-Blind Method Male Robotics Middle Aged Pain Measurement Lidocaine Cardiac Surgical Procedures Anesthetics, Local Female Analgesia, Patient-Controlled Humans Aged Pain, Postoperative Analgesics, Opioid
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