AIMC Topic: Tumor Suppressor Proteins

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Deep learning of the splicing (epi)genetic code reveals a novel candidate mechanism linking histone modifications to ESC fate decision.

Nucleic acids research Dec 1, 2017
Alternative splicing (AS) is a genetically and epigenetically regulated pre-mRNA processing to increase transcriptome and proteome diversity. Comprehensively decoding these regulatory mechanisms holds promise in getting deeper insights into a variety...
Humans Neural Networks, Computer Machine Learning Sequence Analysis, RNA Epigenesis, Genetic Cell Line Cell Differentiation High-Throughput Nucleotide Sequencing Tumor Suppressor Proteins Ubiquitin-Protein Ligases Cell Lineage Alternative Splicing Embryonic Stem Cells Histone Code
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Regulation of demethylation and re-expression of RASSF1A gene in hepatocellular carcinoma cell lines treated with NCTD in vitro.

Journal of cancer research and therapeutics Jan 1, 2015
BACKGROUND: Hepatocellular carcinoma, a lethal malignant neoplasm with poor prognosis, has dismal results of surgical resection and chemoradiotherapy. Norcantharidin (NCTD), the demethylated analog of cantharidin derived from a traditional Chinese me...
Humans In Vitro Techniques Liver Neoplasms Carcinoma, Hepatocellular Gene Expression Regulation, Neoplastic DNA Methylation Blotting, Western Tumor Suppressor Proteins Bridged Bicyclo Compounds, Heterocyclic Tumor Cells, Cultured
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