AIMC Topic: Tumor Suppressor Proteins

Clear Filters Showing 31 to 35 of 35 articles

A quantitative characterization of the heterogeneous response of glioblastoma U-87 MG cell line to temozolomide.

Scientific reports May 8, 2025
Most cancers are genetically and phenotypically heterogeneous. This includes subpopulations of cells with different levels of sensitivity to chemotherapy, which may lead to treatment failure as the more resistant cells can survive drug treatment and ...
Drug Resistance, Neoplasm Tumor Suppressor Proteins Cell Cycle Temozolomide DNA Modification Methylases DNA Repair Enzymes Cell Movement Glioblastoma Cell Line, Tumor Antineoplastic Agents, Alkylating Cell Proliferation Humans Machine Learning Brain Neoplasms
View on PubMed DOI

Intratumoral Resolution of Driver Gene Mutation Heterogeneity in Renal Cancer Using Deep Learning.

Cancer research Aug 3, 2022
UNLABELLED: Intratumoral heterogeneity arising from tumor evolution poses significant challenges biologically and clinically. Dissecting this complexity may benefit from deep learning (DL) algorithms, which can infer molecular features from ubiquitou...
Humans Animals Tumor Suppressor Proteins Nuclear Proteins Kidney Neoplasms Carcinoma, Renal Cell Deep Learning Mutation Ubiquitin Thiolesterase
View on PubMed DOI

MRI to MGMT: predicting methylation status in glioblastoma patients using convolutional recurrent neural networks.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing Jan 1, 2018
Glioblastoma Multiforme (GBM), a malignant brain tumor, is among the most lethal of all cancers. Temozolomide is the primary chemotherapy treatment for patients diagnosed with GBM. The methylation status of the promoter or the enhancer regions of the...
Computational Biology Databases, Genetic Neural Networks, Computer Brain Neoplasms Glioblastoma Dacarbazine Magnetic Resonance Imaging DNA Methylation Humans Temozolomide Antineoplastic Agents, Alkylating Regulatory Sequences, Nucleic Acid Drug Resistance, Neoplasm Tumor Suppressor Proteins DNA Modification Methylases DNA Repair Enzymes
View on PubMed

Deep learning of the splicing (epi)genetic code reveals a novel candidate mechanism linking histone modifications to ESC fate decision.

Nucleic acids research Dec 1, 2017
Alternative splicing (AS) is a genetically and epigenetically regulated pre-mRNA processing to increase transcriptome and proteome diversity. Comprehensively decoding these regulatory mechanisms holds promise in getting deeper insights into a variety...
Alternative Splicing Embryonic Stem Cells Histone Code Ubiquitin-Protein Ligases Cell Lineage High-Throughput Nucleotide Sequencing Tumor Suppressor Proteins Sequence Analysis, RNA Epigenesis, Genetic Cell Line Cell Differentiation Neural Networks, Computer Humans Machine Learning
View on PubMed DOI

Regulation of demethylation and re-expression of RASSF1A gene in hepatocellular carcinoma cell lines treated with NCTD in vitro.

Journal of cancer research and therapeutics Jan 1, 2015
BACKGROUND: Hepatocellular carcinoma, a lethal malignant neoplasm with poor prognosis, has dismal results of surgical resection and chemoradiotherapy. Norcantharidin (NCTD), the demethylated analog of cantharidin derived from a traditional Chinese me...
Tumor Cells, Cultured Tumor Suppressor Proteins Bridged Bicyclo Compounds, Heterocyclic Carcinoma, Hepatocellular DNA Methylation In Vitro Techniques Humans Gene Expression Regulation, Neoplastic Liver Neoplasms Blotting, Western
View on PubMed DOI
Popular Topics
Recent Journals