Artificial Intelligence Medical Compendium

Explore the latest research on artificial intelligence and machine learning in medicine.

Showing 2,321 to 2,330 of 202,214 articles

Precise calcium-to-spike inference using biophysical generative models

bioRxiv Jun 4, 2026
The intramolecular dynamics of fluorescent calcium indicators distort the relationship between calcium signals and action potentials (spikes), hampering efficient spike inference from calcium imaging. To address this problem, we characterized the cal... read more 
neuroscience

A Real-Time Automated Deep Learning Workflow for Non-invasive High-Magnification Imaging of C. elegans

bioRxiv Jun 4, 2026
Caenorhabditis elegans is a premier model organism for aging and neurobiology research, valued for its short lifespan, optical transparency, genetic tractability, and well-mapped nervous system. Non-invasive automated recording of biomarkers is a fun... read more 
bioengineering

Learning residue-level context for modeling protein-protein interactions

bioRxiv Jun 4, 2026
Protein language models (PLMs) enable prediction of protein properties by learning residue-level features from sequence, yet most PLM-based approaches to protein-protein interactions aggregate information across entire proteins, limiting resolution a... read more 
bioinformatics

Predicting P-glycoprotein Substrate Status Using a Pretrained Graph Neural Network: A TDC Benchmark Study

bioRxiv Jun 4, 2026
P-glycoprotein (Pgp/ABCB1) is a critical efflux transporter that significantly impacts drug bioavailability and multidrug resistance. Accurate prediction of Pgp substrate status is essential for early-stage drug discovery. In this study, we evaluate ... read more 
bioinformatics

Visual field map size constrains working memory precision

bioRxiv Jun 4, 2026
Individual differences in working memory are associated with cognitive functioning and real-world outcomes, including general intelligence, academic achievement, and psychiatric and neurological disorders. Despite its importance, the neurobiological ... read more 
neuroscience

R-loop Prediction Reveals Generalization Limits of DNA Foundation Models Beyond Regulatory Genomics

bioRxiv Jun 4, 2026
DNA foundation models are increasingly proposed as general-purpose representations for genomic prediction and design, yet their evaluation remains largely centered on conventional regulatory tasks. This leaves a critical question unresolved: do DNA f... read more 
bioinformatics

An open-source stereotaxic container with an integrated cutting guide for human brain fixation during magnetic resonance imaging and sectioning for histology

bioRxiv Jun 4, 2026
Introduction: Postmortem imaging at ultrahigh field strengths, such as 7 Tesla (7T) magnetic resonance imaging (MRI), enables unprecedented visualization of fine brain structures and pathology. However, precise registration between MRI and histology ... read more 
bioengineering

Direct Detection and Atomic Modeling of Ligands in Cryo-EM Maps Using Deep Learning

bioRxiv Jun 4, 2026
Cryogenic electron microscopy (cryo-EM) has become an increasingly important for structure-based drug discovery by enabling characterization of interactions between macromolecules and small-molecule ligands. However, computational interpretation of l... read more 
bioinformatics

Multi-omic data fusion reveals the in vivo enzyme kinetics of Vibrio natriegens at the genome-scale

bioRxiv Jun 4, 2026
Vibrio natriegens is a halophilic, Gram-negative marine bacterium that is increasingly used in metabolic engineering applications due to its fast growth rate. In sparse minimal medium the organism has a doubling time of 25 minutes, which is about twi... read more 
systems biology

Low-dimensional prefrontal representations of objects during working memory

bioRxiv Jun 4, 2026
There is an ongoing debate regarding the dimensionality of neural representations. Some accounts emphasize representation within low-dimensional subspaces or manifolds, while others suggest high-dimensional neural codes where neurons respond independ... read more 
neuroscience
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