Arthritis

Stage-specific ROMO1 in rheumatoid arthritis: predictive immune insights into the MIF pathway and HLA-DR/IL2RA axis via integrated GWAS, transcriptomic, single-cell, and spatial profiling.

Emerging evidence links reactive oxygen species modulator 1 (ROMO1), a key mitochondrial ROS regulator, to rheumatoid arthritis (RA) pathogenesis. However, its exact mechanism remains elusive given the conflicting evidence about its specific function. We used a four-level integrative framework combining multi-omics data and literature‑supported mechanistic inference. At the genetic level, Mendelia...

Integrated Toxicogenomic Analysis Reveals Potential Molecular Signatures Associated with Cadmium-Related Osteoarthritis.

Osteoarthritis (OA) is a common chronic joint disease, and cadmium (Cd) exposure may contribute to its progression. This study integrated network toxicology, transcriptomic datasets from the Gene Expression Omnibus (GEO), weighted gene co-expression network analysis (WGCNA), and machine-learning methods to identify molecular signatures potentially associated with Cd exposure-related OA. A total of...

Immunoproteomic Profiling of Autoantibodies and Antibodies against Infectious Agents in Autoimmune Diseases.

Prior research investigated limited antibody sets within individual autoimmune diseases. Using the Nucleic-Acid Programmable Protein Array platform, w...

Bibliometric analysis of 50 years of publications in Skeletal Radiology (1976-2025): trends, impact, and global collaboration patterns.

OBJECTIVE: To conduct a comprehensive bibliometric analysis of 50 years of publications in Skeletal Radiology to evaluate publication trends, citation...

AI Cautionary Guide: Pitfalls and Strategies for the Use of Machine Learning in Medical Research.

Machine learning (ML) is increasingly utilized in medical research. However, underrecognized methodological pitfalls can result in misleading conclusi...

Population-scale modeling of the natural knee: automated segmentation, finite element simulation, and machine learning prediction of time-series joint mechanics.

This study combined automated medical image segmentation, hexahedral meshing, and dynamic finite element stance-phase gait simulations with statistica...

Unsupervised machine learning with Cluster Analysis in patients with rheumatoid arthritis: insights in CV risk phenotypes from a multicentre Italian cohort.

Rheumatoid arthritis (RA) patients face increased cardiovascular (CV) risk, yet existing 10-year estimation tools often underperform. This study evalu...

AMD1 regulates cysteine metabolism and ferroptosis sensitivity in rheumatoid arthritis fibroblast-like synoviocytes.

BACKGROUND: Rheumatoid arthritis (RA) is characterized by synovial inflammation and hyperplasia, with fibroblast-like synoviocytes (FLS) playing a key...

Pharmacological personalization of JAK inhibitors in rheumatoid arthritis: A multi-omics and AI-based scoping review and evidence-gap map.

INTRODUCTION: Personalization of Janus kinase inhibitor (JAKi) therapy in rheumatoid arthritis (RA) remains an unresolved clinical task. Multi-omics/m...

Automated Femoral, Acetabular, and Global Offset Measurements on Pelvis Radiograph Using Deep Learning.

PURPOSE: Offset measurement is critical in total hip arthroplasty (THA) for guiding restoration of native anatomy. However, measurements are time-cons...

Multi-Technique Integration Identifies O-GlcNAc Transferase in Fibroblast-Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis.

Rheumatoid arthritis (RA) progression is driven by the pathogenic transformation of stromal fibroblast-like synoviocytes (FLSs). Using artificial inte...

Comparison of artificial intelligence and multidisciplinary team assessment for evaluating biologic decisions in severe uncontrolled asthma.

BACKGROUND: The management of severe asthma with biologics has become more complex involving multidisciplinary team meetings. Artificial intelligence ...

Stromal Vascular Fraction Gel for Osteoarthritis: Mechanisms and Therapeutic Benefits.

Osteoarthritis (OA), a prevalent degenerative joint disorder, is suboptimally managed by existing treatments owing to adverse effects, limited therape...

Exploration of acetylation-related biomarkers in osteoarthritis through bioinformatics analysis.

Osteoarthritis (OA) is characterized as a chronic degenerative disorder affecting the joints. A growing body of evidence indicates that acetylation ma...

Virtual single-cell perturbation and genetic causal inference reveal CSF1R-dependent immunometabolic communication in iron metabolism-associated osteoarthritis.

Iron dysregulation has emerged as a contributor to osteoarthritis (OA), yet the cell-communication mechanisms connecting iron-related genetic signals ...

Generative AI and Clinicians Show Comparable Prognostic Reasoning From Clinical Narratives in Biologic-Treated CRSwNP.

OBJECTIVE: To compare the ability of large language models (LLMs) and otolaryngologists to identify prognostic signals from brief clinical vignettes i...

Current Advances in Spatial Pathology of Nasal Polyps: Challenges, Opportunities for Artificial Intelligence, and Future Directions.

Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by inflammatory heterogeneity, epithelial hyperplasia, and tissue remodeling, with ...

Targeting Airway Remodeling in Severe Asthma: Is There a Window of Opportunity for Biologic Therapy Predicting Effects Using Causal Artificial Intelligence?

Airway remodeling is increasingly recognized as a major determinant of asthma progression, fixed airflow limitation, and long-term morbidity, particul...

Gut microbiota, microbial metabolites, and microbiome-directed nutritional interventions in hyperuricemia and gout: mechanisms and translational opportunities.

Hyperuricemia (HUA) and gout are increasingly prevalent metabolic disorders, imposing a substantial global health burden. Although conventional urate-...

[Advances in deep learning multimodal fusion for early diagnosis of knee osteoarthritis].

Knee osteoarthritis (KOA) is a common chronic degenerative disease that causes pain, functional limitation, and reduced quality of life in middle-aged...