Hemophilia

Activation of sigma non-opioid intracellular receptor 1 (S1R) receptor inhibits plexin domain containing 2 (Plxdc2) driven microglial inflammation to ameliorate depressive-like behaviours in mice.

BACKGROUND AND PURPOSE: Microglia are central regulators of neuroinflammation in depression. Drivers...

Unraveling the Mechanism of Drug Binding to SARS-CoV-2 RNA Pseudoknot With Thermodynamics-Driven Machine Learning.

The pseudoknot secondary structure in SARS-CoV-2 RNA is essential for regulating protein synthesis t...

Disease-modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis after failure of biologic or targeted synthetic therapy: a systematic review and network meta-analysis.

RATIONALE: After inadequate response to first-line biologic or targeted synthetic (b/ts) disease-mod...

A machine learning-driven multitask framework for antibiotic resistance prediction in Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae bloodstream infections among hematological malignancy patients.

BACKGROUND: Inappropriate empirical antimicrobial therapy (IEAT) significantly increases mortality i...

Personalized antiplatelet therapy: are we ready for a precision medicine approach.

Dual antiplatelet therapy (DAPT), combining aspirin with a P2Y12 inhibitor, remains central to secon...

Genotype-Specific Electrophysiological Remodeling in PLN R14del Cardiomyopathy: Implications for Precision Antiarrhythmic Therapy.

BACKGROUND: Inherited PLN (phospholamban) R14del variants cause dilated cardiomyopathy with a high b...

Integrated transcriptomic and experimental validation reveal that N‑acetylcysteine ameliorates acute liver failure through multi‑target synergistic regulation of pyroptosis and related signaling networks.

Pyroptosis is a major contributor to the pathophysiology of acute liver failure (ALF), a condition w...

AI-Powered Discovery of Rosmarinic Acid as a Novel Ferroptosis Inhibitor for Ulcerative Colitis via Targeting the ALOX15-VDAC1 Axis.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited mechanism-based therapi...

Identification of the oxidation stress-related gene signatures and functional verification of MINK1 in prostate cancer cells.

BACKGROUND: A major challenge facing prostate cancer (PCa) cells is oxidative stress, yet the precis...

Experimental and Mechanistic Validation of PARP1pred for Identifying Potent Leads.

Poly(adenosine diphosphate-ribose) polymerase 1 (PARP1) is a pivotal target for treating homologous ...

Advances in Antiviral Drug Development Targeting Viral Proteases.

Viral proteases are critical targets in antiviral drug development due to their essential role in th...

Targeting galactose metabolic reprogramming overcomes immunotherapy resistance in KRAS-mutant lung adenocarcinoma: Integrative multi-omics and machine learning approaches.

BACKGROUND: KRAS-mutant lung adenocarcinoma (LUAD) is associated with aggressive phenotypes and ther...

Developing and validating an interpretable machine learning model for predicting postoperative nausea and vomiting in pulmonary resection patients: a retrospective observational study.

BACKGROUND: Postoperative nausea and vomiting (PONV) remains a prevalent complication hindering Enha...

Integrating machine learning and structure-based simulations to prioritise Z4P as a mutation-resilient IRE1α inhibitor for breast cancer.

Breast cancer is one of the most prevalent and lethal malignancies affecting women globally. The inc...

SAP18 drives vasculogenic mimicry in esophageal squamous cell carcinoma: a machine learning and multi-omics investigation.

Vasculogenic mimicry (VM), a novel endothelial-independent blood perfusion pathway, is linked to adv...

Machine-learning prediction of affinity and epistasis in the bovine pancreatic trypsin inhibitor-chymotrypsin complex.

Protein-protein interactions (PPIs) are shaped by evolutionary pressures that fine-tune binding affi...

When artificial intelligence meets musculoskeletal ultrasound in hemophilia.

Discovery of a novel CaMKⅡα inhibitor by machine learning, molecular docking and molecular dynamics simulation.

CaMKIIα is a central regulator of synaptic plasticity and memory, and its pathological overactivatio...

Elucidating the mechanism of taurine in alleviating osteoarthritis progression based on bioinformatics, machine learning algorithm, and experimental validation.

BACKGROUND: Ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation,...

Selective Effects of Backbone Cyclization and Disulfide Bonding as Global Covalent Constraints on the Conformational Ensemble of Sunflower Trypsin Inhibitor-1.

Backbone cyclization and disulfide bonding are key global covalent constraints in many bioactive pep...

APOBEC mutational signatures predict immune checkpoint inhibitor benefit in TMB-low metastatic NSCLC independent of PD-L1 status.

BACKGROUND: ∼60%-70% of patients with metastatic non-small cell lung cancer (NSCLC) have relatively ...