Rheumatoid Arthritis

Multimodal discovery of a pathogenic B cell-dependent T cell state in multiple sclerosis.

B cell depleting therapies in multiple sclerosis (MS) have transformed disease management, yet the immunological mechanisms linking B cells to chronic compartmentalised CNS inflammation, the key pathological driver of disability accrual, remain poorly defined. Here, we leverage anti-CD20 therapy as an in vivo perturbational probe to disentangle MS immunobiology. We combine longitudinal, high-dimen...

Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-aging compounds from Dengzhan Shengmai formulation.

Aging is a complex biological process involving multiple dysregulated pathways, and synergistic compound combinations offer distinct therapeutic advantages through multi-target and multi-pathway interactions. Traditional Chinese Medicine (TCM) formulations are inherently synergistic, yet systematically identifying their active anti-aging combinations remains a major challenge. Here, we developed D...

Cough Hypersensitivity in Gastroesophageal Reflux-Induced Chronic Cough: Insights from Reflux Monitoring and High-Resolution Manometry.

BACKGROUND: Cough hypersensitivity contributes to the heterogeneity of gastroesophageal reflux-induced chronic cough (GERC), but its associated factor...

Integrating virtual docking and neural network modeling to predict the anti-inflammatory potential of dietary polyphenols in ulcerative colitis.

While the systemic anti-inflammatory benefits of dietary polyphenols are well-established, the specific activities of structurally diverse polyphenols...

Research progress in traditional Chinese medicine for lymphoma: multi-pathway and multi-drug combination approaches.

OBJECTIVES: Lymphoma is a prevalent hematologic malignancy with complex pathogenesis involving dysregulated signaling pathways and high treatment resi...

Modular multi-task deep learning framework for prediction of treatment initiation in neovascular age-related macular degeneration modular AI for NVAMD treatment initiation study-MANTIS.

PURPOSE: The purpose of this study is to develop a fully automated system for determining the optimal time to begin anti-vascular endothelial growth f...

Development of a Prognostic Survival Risk Score for Lung Cancer Patients With Type 2 Diabetes Mellitus: A Territory-Wide Retrospective Cohort Study.

BACKGROUND: Lung cancer is a leading cause of cancer-related mortality, and its prognosis is often affected by comorbidities such as type 2 diabetes m...

Elevated pro-BNP and low-grade inflammation are associated with low bone mineral density in systemic sclerosis, a case control study.

BACKGROUND: Bone mineral density (BMD) is compromised in patients with systemic sclerosis (SSc) compared to the background population, yet the underly...

Silencing SLC52A2 promotes tertiary lymphoid structure formation and inhibits IL-17 pathway to ameliorate melanoma progression.

Tertiary lymphoid structure (TLS) correlates with improved prognosis in melanoma. The role of solute carrier family 52 member A2 (SLC52A2) in mediatin...

Redundancy-aware AI-guided discovery and experimental validation of antimicrobial peptides for infected wound treatment.

Artificial intelligence (AI) is accelerating antimicrobial peptide (AMP) discovery, but prediction-centered workflows often overlook dataset redundanc...

Myocardial Fibrosis in Pediatric Heart Disease: Mechanisms, Imaging Biomarkers, Clinical Consequences, and Emerging Antifibrotic Therapies.

Myocardial fibrosis is increasingly recognized as a central determinant of adverse cardiac remodeling and long-term cardiovascular outcomes in childre...

Machine learning-driven drug repurposing and computational validation for Nipah virus.

The recurring Nipah virus outbreaks and the lack of effective antiviral therapies, emphasize the urgent need for effective therapeutic interventions. ...

Ligustilide and tectoridin from Danggui Buxue Decoction synergistically attenuate atherosclerosis by targeting the CD36/TRPM2 axis and TNF-α/NF-κB pathway.

BACKGROUND: Atherosclerosis (AS) is a common chronic disease and the primary pathological basis for myocardial infarction, stroke, and other disabling...

When Deepfakes Meet Herd Immunity: Artificial Intelligence, Vaccine Avoidance, and the Next Infodemic Threat.

Vaccination remains among the most effective public health interventions, but its impact increasingly depends on public trust and a reliable informati...

Integrated multi-omics and functional analyses reveal a GDCA-TGR5-mediated immunometabolic signature in anorexia nervosa.

BACKGROUND: Anorexia nervosa (AN) is frequently accompanied by metabolic disturbances and immune dysregulation, yet its peripheral molecular mechanism...

Identification of a novel small-molecule modulator targeting SNX10 to inhibit osteoclastic bone resorption.

Current antiresorptive therapies reduce bone loss by eliminating osteoclasts or inhibiting their formation. However, these approaches could disrupt os...

Antimicrobial peptides for tuberculosis in a post-antibiotic era: from in vitro promise to therapeutic potential.

Tuberculosis remains the leading cause of death from a single infectious pathogen, driven by prolonged treatment regimens and escalating drug resistan...

Artificial intelligence-guided discovery of marine scalaranes as selective COX-2 inhibitors through machine learning and molecular modelling.

Anti-inflammatory agents are critical for managing chronic conditions, yet traditional non-selective inhibitors often lead to severe gastrointestinal ...

Comparison of a Computable Pediatric Sepsis Phenotype Tool in Argentinian and U.S. Cohorts.

OBJECTIVE: Sepsis is a leading cause of mortality in low- and middle-income countries. This study identifies computable pediatric sepsis phenotypes (P...

Antimony- and NSAID-Induced Hepatotoxicity at the Molecular Crossroads: Redox, Inflammasome and Programmed Cell-Death Networks as Therapeutic Targets for Natural Hepatoprotective Agents.

Drug- and metal-induced liver damage (DILI/MILI) continues to be a predominant cause of acute hepatic failure globally, with two clinically significan...