FDA General

MESM: integrating multi-source data for high-accuracy protein-protein interactions prediction through multimodal language models.

BACKGROUND: Protein-protein interactions (PPIs) play a critical role in essential biological process...

Non-coding genetic elements of lung cancer identified using whole genome sequencing in 13,722 Chinese.

A substantial portion of lung cancer-associated genetic elements in East Asian populations remains u...

Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation.

Auranofin, an FDA-approved antirheumatic gold drug, has gained ongoing interest in clinical studies ...

Fifty years of monoclonals: the past, present and future of antibody therapeutics.

In 1975, Köhler and Milstein invented hybridoma technology for the generation of murine monoclonal a...

Network-based approach identifies key genes associated with tumor heterogeneity in HPV positive and negative head and neck cancer patients.

Head and Neck Squamous Cell Carcinoma (HNSCC) is the seventh most prevalent cancer worldwide and is ...

BlurryScope enables compact, cost-effective scanning microscopy for HER2 scoring using deep learning on blurry images.

We developed a rapid scanning optical microscope, termed "BlurryScope", that leverages continuous im...

Regulation of biomarker analysis: what can Be translated in the clinic?

INTRODUCTION: The introduction of biomarkers in precision medicine is heralding a new era of diagnos...

Emerging role of AgRP neurons as integrators of metabolic, sensory and environmental cues in the control of energy homeostasis.

The regulation of energy homeostasis is an essential function of every living organism. In mammals a...

In Silico Digital Breast Tomosynthesis Dataset for the Comparative Analysis of Deep Learning Models in Tumor Segmentation.

The scarcity of publicly available digital breast tomosynthesis (DBT) datasets significantly limits ...

Drug repurposing for osteoarthritis disease modification in the Early 21 Century.

Osteoarthritis (OA) is a leading cause of disability worldwide, significantly impacting patient mobi...

Repurposing FDA-approved drugs for treatment of amyotrophic lateral sclerosis using machine learning.

INTRODUCTION: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by lo...

Regulation of the Light Absorption and Photothermal Performance of Melanin-Like Polymers.

ConspectusMelanin-like polymers have attracted significant attention for their excellent light absor...

A Study of Spontaneous Self-Injurious Behavior and Neuroimaging in Rhesus Macaques.

Nonsuicidal self-injury (NSSI) demonstrates escalating prevalence among adolescents as a maladaptive...

A long-term localization and mapping system for autonomous inspection robots in large-scale environments using 3D LiDAR sensors.

Inspection mobile robots equipped with 3D LiDAR sensors are now widely used in substations and other...

Demographic Data Supporting FDA Authorization of AI Devices for Alzheimer Disease and Related Dementias.

Self-Spiking Linear Neuromorphic Soft Pressure Sensor for Underwater Sensing Applications.

Many aquatic vertebrates rely on neuromasts in their lateral line system to detect water vibrations ...

Approaches for regulating enzyme activities: Recent advances in experiment and computation.

Major progress has been made in recent years in terms of strategies for regulating enzyme activities...

Autoparty: Machine Learning-Guided Visual Inspection of Molecular Docking Results.

Human inspection of potential drug compounds is crucial in the virtual drug screening pipeline. Howe...

Use of imaging biomarkers and ambulatory functional endpoints in Duchenne muscular dystrophy clinical trials: Systematic review and machine learning-driven trend analysis.

Duchenne muscular dystrophy (DMD) is a rare X-linked genetic muscle disorder affecting primarily ped...

Novel role of NR1D1 and SLC7A5 in gestational diabetes mellitus: regulation of polyamine metabolism.

BACKGROUND: A potential link exists between gestational diabetes mellitus (GDM) and polyamines, yet ...

Ambulatory physiological state dynamics predict proximal behavioral markers of affect regulation in everyday life.

Human physiology reflects the body's capacity for self-regulation that is crucial for flexible adapt...