Latest AI and machine learning research in cystic fibrosis for healthcare professionals.
N-Acetylcysteine (NAC), a thiol-containing mucolytic agent for COPD, exhibits significant pharmacokinetic variability among patients, motivating the need for convenient therapeutic monitoring. Herein, a colorimetric platform based on copper-doped chiral carbon dots (Cu-D-CDs) was synthesized via a one-pot hydrothermal route using D-histidine and CuCl2 as precursors. The Cu-D-CDs displayed enhanced...
BACKGROUND: Elexacaftor-Tezacaftor-Ivacaftor (ETI) therapy markedly improves pulmonary function in people with cystic fibrosis (pwCF) but induces weight gain, raising concerns about body composition. CT scans routinely performed to assess lung structure offer opportunistic nutritional assessment. In this study, we aimed to evaluate changes in body composition in pwCF after ETI through CT image ana...
BACKGROUND: Despite recent advances, Primary Sclerosing Cholangitis (PSC)-a chronic obstructive biliary disease-still lacks effective therapies to pre...
Nonviral polymeric vectors offer a tunable platform for nucleic acid delivery, yet formulation variables beyond polymer structure remain underexplored...
BACKGROUND: CFTR modulators, including Elexacaftor/Tezacaftor/Ivacaftor (ETI), have markedly improved clinical outcomes for people with cystic fibrosi...
UNLABELLED: Cystic fibrosis (CF) alters gut physiology, yet its impact on microbial communities across colonic regions (ascending, transverse, descend...
BACKGROUND: Cystic fibrosis (CF) monitoring relies on computed tomography (CT), but ultra-short echo time MRI (UTE-MRI) offers a radiation-free altern...
PURPOSE: The purpose of this study was to evaluate the relationship between structural abnormalities on CT and lung function prior to and after initia...
Here, we present a protocol for the rapid functional screening of gene editing and addition strategies in patient-derived organoids using the deep-lea...
INTRODUCTION: In silico tools capable of predicting the functional consequences of genomic differences between individuals, many of which are AI-drive...
Epithelial ion and fluid transport studies in patient-derived organoids (PDOs) are increasingly being used for preclinical studies, drug development a...
Marfan syndrome (MFS) is a hereditary disease with high mortality. This study aimed to explore peripheral blood potential markers and underlying mecha...
In clinical routine, the diagnosis of cystic fibrosis (CF) is still challenging regardless of international consensus on diagnosis guidelines and test...
BACKGROUND: Chest computed tomography (CT) remains the imaging standard for demonstrating cystic fibrosis (CF) airway structural disease . However, vi...
Pre-mRNA splicing is a key controller of human gene expression. Disturbances in splicing due to mutation lead to dysregulated protein expression and c...
causes the fatal fungal bloodstream infection in humans called Candidiasis. Most of the species are resistant to the antifungals used to treat them....
Accurate alternative splicing requires discrimination between adjacent 3' splice sites (3'-ss) during catalysis and is disrupted by pathogenic AG-gain...
Right ventricular (RV) trabeculation may reflect adaptation to loading conditions and imprinting of early developmental processes, yet its genetic det...
Autosomal dominant polycystic kidney disease (ADPKD) exhibits substantial interpatient variability in disease course and therapeutic response, but the...
Overcoming biological barriers remains the paramount challenge for pulmonary mRNA therapeutics. Conventional approaches focus exclusively on passively...