Public Health & Policy

Clinical Trials

Latest AI and machine learning research in clinical trials for healthcare professionals.

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Predicting postoperative coronal imbalance in Lenke 1/2 adolescent idiopathic scoliosis: A machine learning model with clinical interpretability.

OBJECTIVES: Selective posterior thoracic fusion (sPTF) for Lenke 1/2 adolescent idiopathic scoliosis (AIS) aims to reconcile multi-planar correction with motion preservation. Nevertheless, postoperative coronal imbalance (CIB) frequently compromises these objectives. This study developed an interpretable machine learning architecture to stratify CIB risk and identify key predictors. METHODS: Data ...

Jul 18 2026 42469513

Associations of employment status with social media addiction, anxiety, and parenting self-efficacy among mothers of infants: a cross-sectional study using machine learning.

BACKGROUND: Differences in social media addiction, anxiety, and parenting self-efficacy according to maternal employment status have important implications for maternal and child public health. However, evidence comparing these psychosocial outcomes between employed and non-employed mothers of infants remains limited, hindering the development of targeted maternal and child health interventions. T...

Jul 18 2026 42469713
Artificial Intelligence Across the Vaccine Clinical Trial Lifecycle: Evidence, Readiness, and Guardrails.

Artificial intelligence (AI) is increasingly being used to support clinical research, but its value in vaccine clinical trials requires careful eviden...

Jul 17 2026 42464875
A machine learning approach to profiling anxiety risk among cancer patients on treatment.

PURPOSE: Previous literature has identified multiple risk factors for anxiety among individuals with cancer. However, the relative importance across m...

Jul 17 2026 42467265
Quality by Design to Mitigate Aggregation: Mechanistic Insights and Analytical Strategies for Biopharmaceutical Manufacturing.

This review highlights the problem of protein molecule aggregation, which represents a significant challenge in the field of biopharmaceuticals. Prote...

Jul 17 2026 42467318
AI-SOFA: An EMR-integrated Nursing Informatics-driven Decision Support System for Mortality Risk-informed ICU Clinical Decision-making.

Accurate and timely mortality prediction is essential for nursing clinical decision-making in intensive care units (ICUs). Although the Sequential Org...

Jul 17 2026 42467996
Deployment process for artificial intelligence applications in radiology practice.

Successful deployment of medical artificial intelligence (AI) systems should start with formulating clear goals and understanding organisational workf...

Jul 17 2026 42468491
Clinical applications of artificial intelligence in hypertension management: current evidence and future perspectives.

BACKGROUND: Hypertension remains the leading modifiable risk factor for cardiovascular morbidity and mortality worldwide, with persistently inadequate...

Jul 17 2026 42469487
Development of the nursing artificial intelligence readiness scale for nursing students: a validity and reliability study.

BACKGROUND: The rapid integration of artificial intelligence (AI) into healthcare has amplified the need for nurses who can engage with AI-supported s...

Jul 16 2026 42464259
A Guideline-Concordant Chatbot Framework for Structured Colorectal Cancer Screening: Multistage Feasibility Study.

BACKGROUND: Colorectal cancer (CRC) screening relies on structured risk assessment and guideline-concordant communication, which remain challenging to...

Jul 16 2026 42464799
The illusion of competence: Evaluating the clinical reasoning of large language models in pediatric gastroenterology.

OBJECTIVE: To evaluate the diagnostic accuracy and clinical reasoning of three frontier large language models (LLMs) across standardized pediatric gas...

Jul 16 2026 42460647
AI for Causality Assessment in Pharmacovigilance: Protocol for a Scoping Review.

BACKGROUND: Pharmacovigilance aims to protect patient safety by identifying and managing adverse events associated with pharmaceuticals. Determining t...

Jul 16 2026 42462221
Artificial intelligence-assisted detection and optical differentiation of colorectal lesions in Lynch syndrome surveillance (CADLY2): a multicentre, open-label, randomised controlled superiority trial.

BACKGROUND: Artificial intelligence (AI)-based computer-aided detection (CADe) systems improve adenoma detection in average-risk colorectal cancer scr...

Jul 16 2026 42462747
Supporting Research and Graduate Education in a Troubled Landscape: Report of the 2025-2026 AACP Research and Graduate Affairs Committee.

U.S. colleges and schools of pharmacy face mounting challenges in sustaining robust research programs, supporting early-stage investigators, modernizi...

Jul 16 2026 42463021
Can model attribution bridge AI's accountability gap in safety-critical domains?

The current trend of deploying machine learning models as remote services obscures which specific models users are interacting with, exacerbating an a...

Jul 16 2026 42463221
Is it safe to deploy AI in safety-critical systems?

We consider the reality of deploying artificial intelligence (AI) in safety-critical systems, such as autonomous vehicles, medical diagnoses and weath...

Jul 16 2026 42463222
Online safety by design: towards user-centric development of safer AI-based systems.

In this opinion piece, we present the view that the safety and security of end users should be placed at the heart of the design and development of an...

Jul 16 2026 42463225
Artificial Intelligence and Clinician Burnout in the United States: A Narrative Review.

Burnout remains one of the defining occupational hazards of healthcare in the United States, and it spares no one on the care team: physicians, nurses...

Jul 16 2026 42465700
Behavior Change Content and Implementation of Large Language Model-Driven Conversational Agents in Cardiometabolic Care: Scoping Review.

BACKGROUND: Large language models (LLMs) are increasingly embedded in conversational agents for cardiometabolic care. These systems could support self...

Jul 15 2026 42456008
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