Asthma

Comparison of artificial intelligence and multidisciplinary team assessment for evaluating biologic decisions in severe uncontrolled asthma.

BACKGROUND: The management of severe asthma with biologics has become more complex involving multidisciplinary team meetings. Artificial intelligence has been proposed as an adjunct to aid healthcare professionals in other areas of the medical field. OBJECTIVE: Our aim is to determine if there is a role for artificial intelligence, as an adjunct to the severe asthma multidisciplinary team meeting,...

Differential Diagnosis of Asthma and COPD: Established and Emerging Biomarkers and Technologies.

Asthma and chronic obstructive pulmonary disease (COPD) represent the two most prevalent chronic respiratory conditions worldwide, affecting hundreds of millions of individuals and imposing substantial morbidity and mortality. Despite their distinct biological mechanisms, these diseases frequently exhibit overlapping clinical features-including dyspnea, cough, and wheezing-that complicate differen...

Targeting Airway Remodeling in Severe Asthma: Is There a Window of Opportunity for Biologic Therapy Predicting Effects Using Causal Artificial Intelligence?

Airway remodeling is increasingly recognized as a major determinant of asthma progression, fixed airflow limitation, and long-term morbidity, particul...

Identifying and addressing problematic studies in allergy and asthma research: a commentary.

Randomized controlled trials (RCTs) underpin evidence-based medicine, but a growing proportion of trials contain implausible, inaccurate, or fabricate...

An ICD gene set-derived immune contexture signature for colorectal cancer prognosis: integrated single-cell and bulk transcriptomic analysis with external validation.

Immunogenic cell death (ICD) links tumor cell demise with antitumor immunity, but the transcriptional features associated with ICD gene expression pat...

Breathing Life into Data: A Critical Review of Artificial Intelligence and Computational Modelling in COPD Precision Management.

The escalating global burden of chronic obstructive pulmonary disease (COPD) has outpaced the capacity of conventional management paradigms to deliver...

Integrating CBC-derived Inflammatory Biomarkers with Machine Learning for Discriminating Stable and Exacerbated COPD.

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading health burden and global cause of mortality. This study aimed to assess routine ...

Corticosteroid Stewardship: Can it help us avoid the corticosteroid trap? Journal of Allergy and Clinical Immunology: In Practice.

With an almost 20-year experience with asthma biologics, it is now clear that a major impact of all available asthma biologics is the opportunity to r...

The association between serum chloride levels and asthma prevalence: A cross-sectional study with variable screening and validation guided by machine learning.

Prior evidence suggests that ion channel dysfunction plays a significant role in the pathogenesis of asthma, which provides a theoretical basis for th...

Validation of federated analytics across secure data environments: A comparative study of synthetic healthcare datasets using machine learning and general linear models.

OBJECTIVES: To enable research and innovation, most health data systems are moving away from a model of pooled data egress and instead highlight the b...

SMART: structured, meaningful, auditable, responsible, and transparent documentation for clinical AI.

OBJECTIVE: Clinical AI systems and models increasingly need traceable documentation that makes intended use, performance evidence, transparency, and l...

Microbiome-Driven Precision Medicine in Asthma: Roles of Targeted Therapies and Artificial Intelligence.

OBJECTIVE: To evaluate the current evidence regarding airway and gut microbiome alterations in asthma pathogenesis and therapeutic response, and to ex...

Topical exposure to di(2-ethylhexyl) phthalate aggravates atopic dermatitis: an integrated network toxicology, bioinformatics, and experiment analysis.

Di(2-ethylhexyl) phthalate (DEHP) is one of the most widely used plasticizers; however, whether cutaneous DEHP exposure affects atopic dermatitis (AD)...

GPCR Biology-Informed Drug Discovery in Asthma.

Advances in GPCR biology and drug-discovery technology are simultaneously reshaping what can be targeted in asthma and how those strategies must be va...

Large language model accuracy in inhaler technique counselling for asthma and COPD: A comparison of free and paid models across ten devices.

OBJECTIVE: To compare ten large language models (LLMs) from seven AI companies, across free and paid tiers, on inhaler technique instruction accuracy ...

Diagnostic accuracy of electronic medical record retrieval methods and a large language model for identifying cardiovascular events: a multisite retrospective validation study in a medical system in the United States.

OBJECTIVE: To compare the diagnostic accuracy of four available automated electronic medical record (EMR) retrieval methods, including a large languag...

[Advances in the application of artificial intelligence in the whole-course management of bronchial asthma].

Bronchial asthma (asthma) is a common chronic inflammatory airway disease with a steadily increasing global disease burden. Current asthma management ...

Added Value of Expiratory CT in Chronic Airflow Limitation.

BACKGROUND: Expiratory CT and lobar analysis may provide complementary information to inspiratory CT and spirometry for identifying chronic airflow li...

Gut Microbiota and Inflammatory Diseases: Emerging Insights and Therapeutic Perspectives. A Report From the Spanish Inflammatory Diseases Network.

The gut microbiota constitutes a highly complex ecosystem that plays a pivotal role in maintaining human health and modulating the immune response. Dy...

Aberrant mucin expression and keratinization distinguishing severe from mild asthma revealed by interpretable machine learning.

Type 2 (T2) immune cells dominate the airways of mild-moderate asthma (MMA) patients with a more complex Type 1 (T1)-T2 mixed immune response evident ...