Parenting

Association of blood urea nitrogen to high-density lipoprotein ratio with all-cause and cardiovascular mortality in individuals with mildly reduced eGFR.

BACKGROUND: Patients with mild-to-moderate renal impairment face elevated cardiovascular risk, yet early detection tools remain limited. The Cardiovascular-Kidney-Metabolism (CKM) interplay underscores the need for integrated biomarkers. The Blood Urea Nitrogen (BUN) to High-Density Lipoprotein (HDL) cholesterol ratio (BUN/HDL) was therefore evaluated for early risk stratification. METHODS: This c...

Steatosis liver index: A validated machine learning model using clinical data distinguishes steatotic liver disease phenotypes.

INTRODUCTION AND OBJECTIVES: Steatotic liver disease (SLD) is a leading cause of liver disease worldwide. Itsstratified into metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction and alcohol-associated liver disease (MetALD), and alcohol-associated liver disease (ALD) based on self-reported alcohol use remains a challenge. We developed the Steatosis Liver Index (S...

Frailty index deficit interchangeability: an empirical test using random survival forests in adults with cardiovascular disease.

BACKGROUND: The frailty index (FI) assumes that deficits are interchangeable; the type of individual items matters less than the total count. Machine ...

Mourning the loss of AI companions.

As artificial intelligence (AI) shifts from tool use to social interaction, company-initiated updates can disrupt user well-being. Here we develop an ...

Association Between the Dietary Inflammatory Index and Cardiorenal Anemia Syndrome: Evidence From NHANES and Related-Phenotype Exploration in KNHANES.

Cardiorenal anemia syndrome (CRAS) links heart failure, chronic kidney disease, and anemia, but the role of diet-related inflammation remains unclear....

Exploring Emotional Attachment to Socially Assistive Robots: A Qualitative Study Among Older Adults.

Socially assistive robots (SARs) show potential to alleviate loneliness among older adults but raise ethical risks regarding emotional attachment. Whi...

Waist-to-Height Ratio Reveals Hidden Metabolic Risk in Lean Individuals with MASLD.

BACKGROUND: Lean metabolic dysfunction-associated steatotic liver disease (MASLD) can be overlooked in adults with a normal body mass index (BMI). We ...

Artificial Intelligence Integration With Nanotechnology for Cancer Therapy.

Cancer nanomedicine offers a versatile platform for improving therapeutic index, but its clinical translation remains limited by unpredictable in vivo...

Recent trends in nucleic acid research in plants for future food security.

The agricultural production system is facing unprecedented pressure of climate change, human population, pressure on renewable and non-renewable resou...

Artificial Intelligence Meets Micro/Nanorobotics.

Microrobots and nanorobots are a developing technology, which evolved from simple "motoric" motion-capable micro/nanomachines to physical machine inte...

From Human-Centered Results to Real-World Impact: Medical Humanities Cross-disciplinary Research.

This collaboratively written paper presents three case studies where researchers from the humanities and from biomedicine collaborated on topics relat...

Integrating Environmental Exposure Profiles with Temporal Transcriptomics: An Explainable Machine Learning Model for Cardiovascular Disease Risk Prediction and Biological Validation.

BACKGROUND: Cardiovascular disease (CVD) pathogenesis is strongly associated with environmental exposures and metabolic factors. This study aimed to i...

Computational precision nutrition for sarcopenia and associated multimorbidity in ageing.

Sarcopenia is the age-related progressive decline in both skeletal muscle mass and function. It acts as an exacerbator of multimorbidity, engaging in ...

Associations between human oxytocin receptor gene promoter DNA methylation and brain structural connectome in panic disorder in Korea.

AIMS: Epigenetic regulation of the oxytocin receptor gene (OXTR), particularly DNA methylation (DNAm), has been linked to insecure attachment, anxiety...

Quo Vadis in Anatomical Research? Preserving the Conditions for Discovery in an Era of Predictable Outcomes.

Contemporary anatomical research has become increasingly integrated with clinical practice, generating substantial benefits for patient care and stren...

Fatty Acid Signatures as Nutritional Indices: Molecular Gateways to Health, Aging, and Functional Food Innovation.

Fatty acid signatures (FA signatures), defined as the relative distribution of saturated, monounsaturated, and polyunsaturated fatty acids within spec...

Biotech commercialization should be treated as an engineering discipline.

Improving Dietary Data Quality in Nutrition Studies: Development and Validation of an Explainable, Reproducible, Open Machine Learning-Assisted Framework for Outlier Detection in 24-Hour Recalls.

Twenty-four-hour dietary recalls (24HRs) are widely used in nutritional epidemiology, but repeated administration is required to capture within-person...

CompBio and MIRaS-a multi-omic analysis platform built on a memory-based intelligence engine.

As molecular and cellular technologies have advanced, the need to analyze and interpret the resulting vast and multi-modal data into actionable intell...

Intramuscular Fat Assessed by AI-Assisted Muscle Ultrasound: Association With Cardiometabolic Risk Factors and Diabetic Nephropathy in Diabetes Mellitus.

AIMS: Intramuscular fat (IMF) is increasingly recognized as a marker of ectopic adiposity and adverse cardiometabolic outcomes. Artificial intelligenc...