Geriatrics

Latest AI and machine learning research in geriatrics for healthcare professionals.

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Association between ePWV and delirium risk in icu sepsis patients: a retrospective analysis based on the MIMIC database and development of a predictive model.

BACKGROUND: Sepsis, frequently complicated by delirium with poor prognosis, is common in the Intensive Care Unit (ICU). Estimated Pulse Wave Velocity (ePWV), a non-invasive arterial stiffness marker, remains unexplored regarding delirium risk in ICU sepsis patients. This study investigated ePWV's association with sepsis-linked delirium and developed a predictive model. METHODS: This retrospective ...

Sep 5 2026 42700537

SilicoXplore: An integrated cloud platform coupling machine learning with physics-based modelling for end-to-end drug discovery, applied to the computational prioritisation of putative New Delhi metallo-β-lactamase-1 binders.

Modern drug discovery joins machine learning with physics-based simulation, but building such a pipeline needs Linux administration, dependency management, format conversion and scripting, which keeps out many of the chemists and biologists who ask the questions. We describe SilicoXplore, a cloud-hosted platform of 31 interoperable modules covering structure preparation, five docking engines, de n...

Sep 4 2026 42700759
Frailty index deficit interchangeability: an empirical test using random survival forests in adults with cardiovascular disease.

BACKGROUND: The frailty index (FI) assumes that deficits are interchangeable; the type of individual items matters less than the total count. Machine ...

Sep 4 2026 42696642
Multimodal Large Language Models for Dental Chart Image Interpretation: Cross-Sectional Benchmarking Study With Students and Clinicians.

BACKGROUND: Entering clinical training, dental students must learn to read tooth-centered electronic dental records, but limited teaching time in pati...

Sep 4 2026 42696739
Targeting the mitochondrial functional network: Decoding upstream pathological mechanisms and novel therapeutic paradigms for Alzheimer's disease.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder worldwide. Conventional downstream interventions targeting β-amyloid (Aβ) an...

Sep 4 2026 42697335
Breaking the Autophagy-Oxidative Stress Vicious Cycle in Alzheimer's Disease: Lactiflorin Unlocks P62 Dual Phosphorylation via ULK1 Targeting.

ETHNOPHARMACOLOGICAL RELEVANCE: The dried root of Paeonia lactiflora Pall. has a long history of medicinal use in traditional Chinese medicine. Classi...

Sep 4 2026 42697496
MST-Net: a multi-scale spatial transformation network for automated T2/T3 staging of rectal cancer on preoperative T2-weighted MRI.

OBJECTIVE: This study aimed to develop a deep learning model (MST-Net) for the segmentation-free automated and precise differentiation between T2 and ...

Sep 4 2026 42698053
Development of a YOLO-guided automated (microplastic) particle analysis workflow.

Microplastics (MPs) are an emerging pollutant of global concern, creating an urgent need for rapid and accurate monitoring workflows. Deep learning-ba...

Sep 4 2026 42694007
Long-PVSUNet: A Longitudinal Deep Learning Framework for Count-Oriented Perivascular Space Segmentation in Brain MRI.

Enlarged perivascular spaces (ePVS) are small, sparse MRI-visible markers of cerebral small vessel disease and brain ageing. Their size, low contrast,...

Sep 3 2026 42690525
Development and validation of a machine learning-based diagnostic prediction model for frailty in older adults with diabetes.

BACKGROUND: Frailty is a significant risk factor for death and disability in older adults with diabetes. Early identification of frailty in this popul...

Sep 3 2026 42691928
Deep Learning Method Based on Multimodal Medical Image Fusion for Predicting Acute Vertebral Fracture.

RATIONALE AND OBJECTIVES: The study aimed to develop and validate a deep learning (DL) model based on X-ray and computed tomography (CT) to diagnose a...

Sep 3 2026 42692873
From Volumetrics to 3D Tensors: A Multi-Cohort Evaluation of Machine Learning and Deep Learning for Alzheimer's Classification.

Automated Alzheimer's disease (AD) classification from structural MRI typically employs either feature-engineered machine learning (ML) or end-to-end ...

Sep 3 2026 42693331
Toward harmonized reporting of Alzheimer's disease biomarkers in clinical practice.

Cerebrospinal fluid biomarkers, and more recently blood-based biomarkers, are playing a pivotal role in reshaping the clinical management of neurodege...

Sep 3 2026 42683894
Post-traumatic Psychopathology and Cardiovascular Risk: A Danish Case-Control Study of Sex-Specific Associations.

BACKGROUND: There is increasing recognition that trauma exposure and related psychiatric consequences predict cardiovascular disease risk. However, mo...

Sep 2 2026 42684053
Machine learning classification of mild Alzheimer's disease using EEG during emotional processing.

BackgroundMild Alzheimer's disease (AD) is associated with alterations in brain activity, which can be detected using electroencephalography (EEG). In...

Sep 2 2026 42685686
Harmonizing complexity and efficiency: Helix Fusion HarmonyNet's breakthrough in EEG-based postoperative delirium recognition.

Postoperative delirium (POD) is a common perioperative complication involving central nervous system dysfunction, particularly among critically ill an...

Sep 2 2026 42685753
Assessment of elemental decomposition algorithms for particle therapy dose monitoring using positron emission tomography and prompt-gamma imaging.

Accurate dose verification remains a major challenge in particle therapy. Dose monitoring methods such as positron emission tomography (PET) and promp...

Sep 2 2026 42685782
AI for Opportunistic Identification of BMD and Bone Microarchitecture: A Narrative Review.

Artificial intelligence (AI) has rapidly transformed the potential for opportunistic assessment of bone mineral density (BMD) and bone microarchitectu...

Sep 2 2026 42687048
From assistant to collaborator: A systematic review of the evolution of artificial intelligence in end-stage renal disease care and management.

We aimed to systematically analyze the historical evolution of artificial intelligence (AI) in end-stage renal disease (ESRD) management and propose a...

Sep 2 2026 42685099
Bridging language markers and pathology: correlations between digital speech measures and surrogate CSF biomarkers in Alzheimer's disease.

INTRODUCTION: Digital language markers show promise in detecting early cognitive impairment related to Alzheimer's disease (AD), yet their relationshi...

Sep 2 2026 42688514
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