Other Cancers

Ex vivo JAK and TNF inhibitor-modulated immune signatures guide first-line therapy selection in rheumatoid arthritis.

BACKGROUND: Rheumatoid arthritis (RA) is a heterogeneous autoimmune disease for which selecting the ...

De Novo Design of a TROP-2-Targeting Peptide PET Tracer via AI-Guided Binding Interface Mimicry.

Trophoblast cell surface antigen 2 (TROP-2) is a transmembrane glycoprotein overexpressed across a r...

Multitask Deep Learning Model for Predicting Lymph Node Metastasis and Disease-Free Survival From Cytology Images in Bladder Cancer: A Multicenter Study With Pan-Cytology Validation.

Accurate prediction of lymph node metastasis (LNM) and survival outcomes is crucial for personalized...

Colorectal cancer surveillance in Lynch syndrome: quality standards, emerging technology and complementary strategies.

Lynch syndrome is the most common hereditary colorectal cancer syndrome, and colonoscopy remains the...

Inferring tissue origin from cell-free DNA in metastatic cancer.

A major clinical challenge in metastatic cancer management is determining not only the presence of t...

Cardiovascular Toxicity Across the Cancer Immunotherapy Spectrum: Mechanisms and Management in Immune Checkpoint Inhibitor (ICI) and Chimeric Antigen Receptor T-Cell (CAR-T) Therapy.

PURPOSE OF REVIEW: This review evaluates the evolving landscape of cardiovascular toxicities associa...

Benchmark Evaluation of Vision-Enabled Large Language Models in Mammography: A Case-Control Study.

OBJECTIVE: To compare the diagnostic performance of five contemporary vision-enabled large language ...

Development of a Novel Real-Time Computer-Assisted Colonoscopy Diagnostic Tool for Colorectal Neoplasia and Cancer to Enable Personalized Patient Management: Protocol for a Multicenter Proof-of-Concept Study.

BACKGROUND: Accurate real-time classification of colorectal polyps during colonoscopy is essential f...

Integrative single-cell and computational pathology analyses reveal a C11orf24-associated stem-like epithelial population linked to tumor microenvironment remodeling and immune evasion in bladder cancer.

BACKGROUND: Cancer stem-like cells drive tumor progression and therapeutic resistance, yet the epith...

TRACE-CLDN: An Integrated Computational Pathology Framework for Tumor-Restricted Quantification of CLDN18.2 Expression Burden from H&E Whole-Slide Images in Intrahepatic Cholangiocarcinoma.

Claudin-18.2 (CLDN18.2) is a membrane-associated biomarker with emerging translational relevance in ...

Comment on "machine learning prognostication in nasopharyngeal carcinoma: a european multicentre analysis of survival and risk of second malignancy" - when the best second-cancer model cannot beat predicting "no" for everyone.

Application of machine learning to identify risk factors for bloodstream infections caused by different antimicrobial resistance phenotypes in chemotherapy patients.

PURPOSE: Bloodstream infections (BSIs) remain a major cause of morbidity and mortality in patients u...

Machine learning-based CT radiomics for identifying high risk esophageal varices of bleeding in hepatocellular carcinoma.

PURPOSE: Esophageal variceal (EV) bleeding is a lethal complication in patients with hepatocellular ...

A WSI-Independent Inference Framework for Cervical and Urinary Cytology Using Hierarchical Labels.

BACKGROUND: Cytology artificial intelligence (AI) systems often depend on whole-slide images (WSIs) ...

Data-Driven Comorbidity Phenotypes and In-Hospital Outcomes Among Patients With Nonvariceal Upper Gastrointestinal Bleeding: Formative Retrospective Cohort Study.

BACKGROUND: Existing risk scores for nonvariceal upper gastrointestinal bleeding (NVUGIB) may not ad...

Psychosocial Distress and Radiation Treatment Interruptions in Patients With Cancer Using Machine Learning and Regression: Retrospective Cohort Study.

BACKGROUND: Uninterrupted delivery of radiation therapy is critical to cancer treatment quality. Unp...

Emerging Role of AI in Single-Cell Sequencing Toward Biomarker Discovery, Therapeutic Target Identification and Precision Medicine in Lung Cancer.

Lung cancer, the most common malignancy worldwide, exists in numerous histological subtypes, renderi...

Super Resolution Reconstruction: A Strategy to Improve the Diagnostic Performance of Radiomics for Predicting Microvascular Invasion in Hepatocellular Carcinoma.

RATIONALE AND OBJECTIVES: Microvascular invasion (MVI) is a key factor associated with high postoper...

Recovering CDR3 sequences from RNA-seq data: a critical assessment of computational and experimental strategies.

The adaptive immune response depends on T cell receptor (TCR) diversity to counter cancers, autoimmu...

Oncogenic mutations in non-small cell lung cancer: from molecular mechanisms to clinical practice.

Targeted therapy has revolutionized the treatment of non-small cell lung cancer (NSCLC) patients har...

Defining the Clinical Indication for Real-Time Artificial Intelligence-Assisted Ultrasound in Breast Lesions with Low Suspicion of Malignancy.

OBJECTIVES: To evaluate whether real-time artificial intelligence (AI) breast ultrasound (US) can id...