Infectious Disease

Association between ePWV and delirium risk in icu sepsis patients: a retrospective analysis based on the MIMIC database and development of a predictive model.

BACKGROUND: Sepsis, frequently complicated by delirium with poor prognosis, is common in the Intensive Care Unit (ICU). Estimated Pulse Wave Velocity (ePWV), a non-invasive arterial stiffness marker, remains unexplored regarding delirium risk in ICU sepsis patients. This study investigated ePWV's association with sepsis-linked delirium and developed a predictive model. METHODS: This retrospective ...

Application of Emerging Technologies in the Antiviral Field.

Viral diseases pose a serious threat to global public health, agriculture, and biosecurity. Conventional antiviral strategies are often limited by an incomplete understanding of disease mechanisms, poor targeting precision, and slow response times. Emerging technologies are now reshaping the landscape of antiviral research. This review examines the roles of four key frontiers, including organoid m...

Structure prediction and drug screening targeting monkeypox virus polymerase and surface proteins.

The global outbreak and ongoing spread of the monkeypox virus (MPXV) have highlighted the urgent need for effective antiviral therapeutics. Here, we i...

Combating New Delhi metallo-beta-lactamase-1 (NDM-1): an integrated review of inhibitor development and next-generation therapeutic platforms.

New Delhi metallo-β-lactamase-1 (NDM-1), which has emerged globally, exhibits resistance to almost all β-lactam antibiotics, including carbapenems, po...

Immunoproteomic Profiling of Autoantibodies and Antibodies against Infectious Agents in Autoimmune Diseases.

Prior research investigated limited antibody sets within individual autoimmune diseases. Using the Nucleic-Acid Programmable Protein Array platform, w...

Large Language Models for Heterogeneous Data Mining in Liver Disease: Framework Development and Retrospective Validation Study.

BACKGROUND: Differentiating among liver disease entities such as autoimmune liver disease (AILD), drug-induced liver injury (DILI), and chronic hepati...

Real-Time Nanoscale Multiparametric Biophysical Phenotyping of Single Cells by Surface Plasmon Resonance Microscopy.

How cell physical state relates to function and stimulus response remains difficult to resolve because most methods measure only one biophysical prope...

Comparative analysis of human papilloma virus detection methods and prognostic significance of transcriptionally active viral load in oropharyngeal squamous cell carcinoma.

BACKGROUND: Human papilloma virus (HPV)-related head and neck squamous cell carcinoma (HNSCC) incidence is rising. Despite the prognostic and therapeu...

Novel RT‒qPCR-based blood signatures for the diagnosis of pulmonary tuberculosis.

Whole-blood gene expression has the potential to become an affordable alternative for the diagnosis of pulmonary tuberculosis (TB). Through an immune-...

Programmable design of synthetic plant immune receptors for pathogen protein recognition.

The limited diversity and recognition scope of natural plant immune receptors impede resistance breeding against rapidly evolving pathogens. Here, we ...

Ecological Filtering by Tuber Compartments Shapes Stable Core Microbiomes That Underpin Potato Plant Growth Across Environments.

Harnessing plant microbiomes for sustainable agriculture requires understanding not only whether they can boost crop performance, but also how ecologi...

Oral and gut microbiota profiles in patients with locally advanced rectal cancer with varying responses to neoadjuvant chemoradiotherapy.

Recent research has focused on gut bacteria in colorectal cancer, but the influence of other microbiota, including oral and nonbacterial gut microbiot...

A unified framework for potency-oriented AMP discovery via multi-modal learning and guided sequence synthesis.

The rapid emergence of drug-resistant pathogens poses a critical threat to global health. With traditional antibiotics losing efficacy, antimicrobial ...

Recent Advances in Surface-Enhanced Raman Spectroscopy for Virus Detection.

Since the onset of the COVID-19 pandemic in 2020, the importance of virus detection and development of new diagnostics for emerging or evolving viruse...

Temporal validation of machine-learning models for shingles vaccine nonvaccination among U.S. adults aged 50 years and older.

BACKGROUND: Herpes zoster vaccination is recommended for U.S. adults aged 50 years and older, yet many remain unvaccinated. Prior National Health Inte...

Global Freshwater Resistomes Reveal Environmental Signatures Associated with the Burden of Drug-resistant Tuberculosis.

Antimicrobial resistance (AMR) is a growing global health threat, yet the extent to which environmental resistomes reflect human disease burden remain...

De novo generation and computational screening of dual-targeting short peptide inhibitors against PBP2b and PBP2x in drug-resistant Streptococcus Pneumoniae.

Deep learning has greatly advanced de novo protein design, yet its application to rational short peptide design remains underexplored. Here, we develo...

Free energy perturbation and machine learning-assisted identification of novel molecules for the Mycobacterium tuberculosis KasA protein: a fragment-based drug design approach.

KasA is an essential enzyme of Mycobacterium tuberculosis (Mtb). It plays a critical role in synthesizing long-chain mycolic acids, the major componen...

Machine Learning-Based Subtype Classification of Sepsis-Associated Acute Kidney Injury and Differential Responses to Renal Replacement Therapy.

BackgroundSepsis-associated acute kidney injury (SA-AKI) is highly heterogeneous with controversial optimal renal replacement therapy (RRT) strategies...

Induction and Enhancement of Bacteriocin Production (Review).

Conventionally, bacteriocins are produced by microorganisms on complex substrates, released as semi-purified preparations or crude fermentates. These ...