Addictions

Multifunctional Hydrogen-Bonded Organic Frameworks for Intelligent Anti-Counterfeiting and Food Safety Monitoring.

In an era of increasing digital threats and product counterfeiting, this study introduces MA-IPA@NPA, a groundbreaking hydrogen-bonded organic framework (HOF) material designed for advanced anticounterfeiting applications. This innovative material showcases distinctive optical properties, including dual fluorescence-phosphorescence emission and an ultralong phosphorescence lifetime, making it exce...

Future Perspectives of Liver Research in the Asia-Pacific Region: Focus on Hepatitis B and C.

The Asia-Pacific region faces serious liver health challenges, primarily because of the comparatively high prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, as well as the increasing disease burden of metabolic-associated steatotic liver disease (MASLD), alcohol-associated liver disease, and hepatocellular carcinoma (HCC). Despite MASLD being the cause with the highest ...

Clinical significance of computer-aided quality assessment systems in colonoscopy: a comprehensive review.

Colonoscopy is the primary tool for colorectal cancer screening. High-quality colonoscopy is crucial for the detection of precancerous adenomas; howev...

Enhancing liver disease diagnosis with hybrid SMOTE-ENN balanced machine learning models-an empirical analysis of Indian patient liver disease datasets.

INTRODUCTION: The liver is one of the vital organs of human body that performs some of the most crucial biological processes such as protein and bioch...

The future of target-controlled infusion and new pharmacokinetic models.

PURPOSE OF REVIEW: To summarize recent developments in the understanding of the pharmacology of the hypnotic and opioid drugs, with relevance to targe...

Identifying key risk factors for intentional self-harm, including suicide, among a cohort of people prescribed opioid agonist treatment: A predictive modelling study.

BACKGROUND AND AIMS: People with opioid use disorder are at increased risk of intentional self-harm and suicide. Although risk factors are well known,...

Development of a Heart Rate Variability Based Ambulatory Stress Detection Model for Clinical Populations.

Biosensor-based, real-time stress detection has generated clinical interest for the purpose of driving just-in-time interventions that support recover...

Automated detection of severe cerebral edema using explainable deep transfer learning after hypoxic ischemic brain injury.

BACKGROUND: Substantial gaps exist in the neuroprognostication of cardiac arrest patients who remain comatose after the restoration of spontaneous cir...

The Digital Transformation of Healthcare Through Intelligent Technologies: A Path Dependence-Augmented-Unified Theory of Acceptance and Use of Technology Model for Clinical Decision Support Systems.

Integrating Artificial Intelligence Clinical Decision Support Systems (AI-CDSSs) into healthcare can improve diagnostic accuracy, optimize clinical w...

Graphene Oxide-Modulated CMC/PVA Films with on-Demand Shape Recovery and Self-Healing Performance.

With the advancement of artificial intelligence technologies, shape-memory polymers (SMPs) have attracted significant research interest due to their r...

New Insights into the Diagnosis and Treatment of Hepatocellular Carcinoma.

Hepatocellular carcinoma remains one of the leading contributors to global cancer mortality, frequently stemming from chronic liver conditions, such a...

Uncemented hip arthroplasty and denosumab: increased postoperative dipeptide concentrations and identification of potential new bone turnover biomarkers.

Denosumab is a potent antagonist of RANKL and is widely used to treat severe postmenopausal osteoporosis. Using high-resolution mass spectrometry (HRM...

Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program.

Substance use disorders (SUDs), including Alcohol Use Disorder, are pressing global public health problems. Executive functions (EFs) are prominently ...

Artificial Intelligence (AI)-Driven Approaches to Manage Postoperative Pain, Anxiety, and Psychological Outcomes in Surgical Patients: A Systematic Review.

Postoperative pain, anxiety, and psychological distress significantly impact surgical recovery, yet conventional management strategies often lack pers...

Milk residue concentrations of ivermectin following pour-on administration to pregnant Holstein cows during different dry periods.

This study aimed to compare ivermectin residue concentrations in milk following pour-on administration to Holstein cows at different stages of the dry...

Lipopolysaccharide-induced abdominal nociception model in adult zebrafish (Danio rerio).

In this study, a behavioral model of LPS-induced abdominal nociception was developed in adult zebrafish (Danio rerio), aZF. Initially, the toxicity of...

A Randomized, Blinded, Placebo-Controlled Crossover Study of the Pharmacokinetics and Pharmacodynamics of Naloxone, Naltrexone, and Nalmefene in Methadone-Sedated Working Dogs.

A randomized, blinded, placebo-controlled crossover study was performed with eight professional working dogs to evaluate the pharmacokinetics and phar...

Efficacy of eprinomectin 5 mg/mL topical solution administered twice pour on at 1 mg per kg body weight against sarcoptic mange (Sarcoptes scabiei) in sheep.

Sarcoptic mange of sheep is a skin disease which compromises the health and welfare of the animals, impacts their productivity and is zoonotic. In Eur...

Supervised and unsupervised learning reveal heroin-induced impairments in astrocyte structural plasticity.

Astrocytes regulate synaptic activity across large brain territories via their complex, interconnected morphology. Emerging evidence supports the invo...

Applying user-centred techniques and expert feedback to refine an AI-based app for addressing mobile gaming addiction in adolescents.

BACKGROUND: The prevalent use of smartphones has contributed to a rise in mobile gaming addiction, especially in young people. This study aimed to des...