Psychiatry

Addictions

Latest AI and machine learning research in addictions for healthcare professionals.

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Counterfactually Fair Reinforcement Learning via Sequential Data Preprocessing

When applied in healthcare, reinforcement learning (RL) seeks to dynamically match the right inter...

A Brain Age Residual Biomarker (BARB): Leveraging MRI-Based Models to Detect Latent Health Conditions in U.S. Veterans

Age prediction using brain imaging, such as MRIs, has achieved promising results, with several stu...

Molecular unbalances between striosome and matrix compartments characterize the pathogenesis of Huntington’s disease model mouse

The pathogenesis of Huntington’s disease is still incompletely understood, despite the remarkable ad...

In vivo Quantification of Neural Criticality and Complexity in Mouse Cortex and Striatum in a Model of Cocaine Abstinence

Self-organized criticality is a hallmark of complex dynamic systems at phase transitions. Systems th...

Astrocyte-Guided Maturation of Neural Constructs in a Modular Biosynthetic Hydrogel for Biohybrid Neurotechnologies

Bionic implants are increasingly used to restore neural function yet achieving a chronically stable ...

Modeling Withdrawal States in Opioid-Dependent Mice with Machine Learning

Understanding opioid withdrawal behaviors in preclinical models is critical to improving therapeutic...

Population analyses reveal heterogenous encoding in the medial prefrontal cortex during naturalistic foraging

Foraging in the wild requires coordinated switching of critical functions, including goal-oriented n...

The Human Omnibus of Targetable Pockets

Hundreds of computational methods for predicting ligand binding pockets exist, but the problem of fi...

Multi-Class Classification of Cannabis and Alcohol Use Disorder: Identifying Common and Substance-Specific Neural Circuits

Machine learning approaches have advanced the identification of neural signatures of substance use, ...

A blueprint for mutation-defined hallmark vulnerabilities across human cancers

Hallmark gene mutations shape cancer cell vulnerabilities and inform drug discovery1–3. A systematic...

Adolescent alcohol consumption alters sex-specific behaviors associated with prefrontal functional connectivity in mice

The prefrontal cortex (PFC) is one of the last brain regions to fully mature, making it particularly...

A unified model of short- and long-term plasticity: Effects on network connectivity and information capacity

Activity-dependent synaptic plasticity is a fundamental learning mechanism that shapes connectivity ...

qcGEM: a graph-based molecular representation with quantum chemistry awareness

The advancement of artificial intelligence (AI) has reshaped drug discovery. AI-based models typical...

BCL-XL Dependence is a Subtype Agnostic Actionable Feature of Difficult-to-Treat Kidney Cancers

The BCL-XL anti-apoptotic protein is a clear cell Renal Cell Carcinoma (ccRCC) dependency; however, ...

Short-Term Mortality After Opioid Initiation Among Opioid-Naïve and Non-Naïve Patients with Dementia: A Retrospective Cohort Study

Despite the ongoing opioid epidemic, the mortality risk of opioid initiation in patients with dement...

DUNE: a versatile neuroimaging encoder captures brain complexity across three major diseases: cancer, dementia and schizophrenia

Magnetic resonance images (MRI) of the brain exhibit high dimensionality that pose significant chall...

Data-Driven Insights on Opioid Use and Health Behavior Trends Following Decriminalization: Zero-Shot Sentiment and Behavior Analysis

Opioid decriminalization has taken on renewed urgency in regions grappling with high mortality and h...

LLM-Guided Pain Management: Examining Socio-Demographic Gaps in Cancer vs non-Cancer cases

Large language models (LLMs) offer potential benefits in clinical care. However, concerns remain reg...

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