Addictions

Intranasal Abuse Potential, Pharmacokinetics, and Safety of Once-Daily, Single-Entity, Extended-Release Hydrocodone (HYD) in Recreational Opioid Users.

OBJECTIVES: A once-daily, extended-release hydrocodone bitartrate tablet with abuse-deterrent properties (Hysingla ER® [HYD]) is available for the treatment of chronic pain in appropriate patients. This study evaluated the intranasal abuse potential and pharmacokinetics of HYD coarse and fine particles vs hydrocodone powder or placebo.

The utility of automated measures of ocular metrics for detecting driver drowsiness during extended wakefulness.

Slowed eyelid closure coupled with increased duration and frequency of closure is associated with drowsiness. This study assessed the utility of two devices for automated measurement of slow eyelid closure in a standard poor performance condition (alcohol) and following 12-h sleep deprivation. Twenty-two healthy participants (mean age=20.8 (SD 1.9) years) with no history of sleep disorders partici...

A Spiking Neural Network Methodology and System for Learning and Comparative Analysis of EEG Data From Healthy Versus Addiction Treated Versus Addiction Not Treated Subjects.

UNLABELLED: This paper introduces a method utilizing spiking neural networks (SNN) for learning, classification, and comparative analysis of brain dat...

Automated Extraction of Substance Use Information from Clinical Texts.

Within clinical discourse, social history (SH) includes important information about substance use (alcohol, drug, and nicotine use) as key risk factor...

Integrated analysis of oral tongue squamous cell carcinoma identifies key variants and pathways linked to risk habits, HPV, clinical parameters and tumor recurrence.

Oral tongue squamous cell carcinomas (OTSCC) are a homogeneous group of tumors characterized by aggressive behavior, early spread to lymph nodes and a...

A biosensor based on laccase immobilized on nitrogen-doped multiwalled carbon nanotubes and graphene oxide for polyphenol detection.

The use of nanomaterials allows the design of ultrasensitive biosensors with advantages in the detection of organic molecules. Catechol and catechin a...

In vitro, ex vivo and in vivo anti-hypertensive activity of Chrysophyllum cainito L. extract.

Chrysophyllum cainito L., a traditional herbal medicine, could have the potential for management of hypertension due to presence of polyphenolic compo...

Effects of the herb mixture, DTS20, on oxidative stress and plasma alcoholic metabolites after alcohol consumption in healthy young men.

BACKGROUND: This study was designed to investigate the effect of a herbal mixture extract (DTS20) on the attenuation of oxidative stress and hangover ...

MDD-SOH: exploiting maximal dependence decomposition to identify S-sulfenylation sites with substrate motifs.

UNLABELLED: S-sulfenylation (S-sulphenylation, or sulfenic acid), the covalent attachment of S-hydroxyl (-SOH) to cysteine thiol, plays a significant ...

Machine learning on encephalographic activity may predict opioid analgesia.

BACKGROUND: Opioids are used for the treatment of pain. However, 30-50% of patients have insufficient effect to the opioid initially selected by the p...

PsyGeNET: a knowledge platform on psychiatric disorders and their genes.

UNLABELLED: PsyGeNET (Psychiatric disorders and Genes association NETwork) is a knowledge platform for the exploratory analysis of psychiatric disease...

Neural networks for identifying drunk persons using thermal infrared imagery.

Neural networks were tested on infrared images of faces for discriminating intoxicated persons. The images were acquired during controlled alcohol con...

Analysis of connectivity in NeuCube spiking neural network models trained on EEG data for the understanding of functional changes in the brain: A case study on opiate dependence treatment.

The paper presents a methodology for the analysis of functional changes in brain activity across different conditions and different groups of subjects...

Impact of robot-assisted laparoscopic prostatectomy on the management of general anesthesia: efficacy of blood withdrawal during a steep Trendelenburg position.

INTRODUCTION: Robot-assisted laparoscopic prostatectomy (RALP) is being increasingly used. However, a steep Trendelenburg position and pneumoperitoneu...

Functional outcomes after TORS for oropharyngeal cancer: a systematic review.

Summarize functional outcomes after transoral robotic surgery (TORS) ± adjuvant therapy for oropharyngeal cancer (OPC). A systematic review was conduc...

Artificial Intelligence for Energy Optimization in Data Centers

Data centers are increasingly optimized by artificial intelligence and, at the same time, increasingly loaded by it. The literature treats these as tw...

Half of alcohol, drug, and self-harm presentations cannot be identified in coded emergency department data: a diagnostic accuracy study of a large language model

Objective To measure the accuracy of clinical coding, clinician review, and a locally deployed large language model (LLM) in identifying alcohol, drug...

Evaluating computational assays of chronic fatigue using UK Biobank data

Chronic fatigue, characterized by persistent physical and/or mental exhaustion, is a frequent and debilitating symptom in medicine. Despite its impact...

Modifiable Contributors to Socioeconomic Inequality in Brain Aging

Importance Socioeconomic disadvantage is associated with accelerated brain aging. However, the modifiable factors accounting for this association, and...

Unmasking Toxic Mimicry in Medical Offline Reinforcement Learning for ICU Sepsis Management via Counterfactual Clinical Audits

Offline reinforcement learning (RL) offers considerable promise for optimizing ICU treatment decisions, yet standard evaluation metrics Mean Squared E...