Psychiatry

Addictions

Latest AI and machine learning research in addictions for healthcare professionals.

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Multimodal neuroimaging-microbiota integration identifies Akkermansia as a modulator of alcohol-induced gut-liver-brain pathology

Alcohol use disorder (AUD) disrupts the gut-liver-brain axis, yet mechanistically grounded and therapeutically actionable targets within this network remain poorly defined. To identify microbial modulators of alcohol-induced tissue pathology, longitudinal advanced diffusion MRI and fecal 16S rRNA profiling were integrated across Marchigian Sardinian alcohol-preferring rats evaluated at baseline, a...

A Comparative Study of Feature Selection Methods for EHR Diagnosis Codes in Opioid Use Disorder Prediction

Feature selection is a critical step in electronic health record (EHR)-based predictive modeling, where input variables are often high-dimensional, sparse, noisy, and redundant. Large feature sets not only increase computational burden and overfitting risk, but also make model interpretation difficult, leading to limited usefulness in clinical settings. In this study, we focus on diagnosis-related...

Aug 4 2026 2608.04180v1
FaithEyes: Towards Faithful Tool Use via Multi-Agent Process-Image Verification

Agentic vision-language models (VLMs), which interleave textual reasoning with explicit tool calls such as cropping and code-based image manipulation,...

Jul 30 2026 2607.28225v1
See2Think: Do Multimodal Models Really Use Intermediate Visual States?

Multimodal large language models increasingly use sketches, annotations, tools, and intermediate images during reasoning, but it remains unclear wheth...

Jul 29 2026 2607.26769v1
Bayesian Feature Extraction using Gaussian and Diffused-gamma Priors for High Dimensional Spatio-Temporal Data

High-dimensional data with sparse structure and spatio-temporal dependence arise in many scientific domains. We develop a Bayesian feature-extraction ...

Jul 27 2026 2607.24378v1
Assessing Pain Catastrophizing Through Free-Text Responses: A Validation of Large Language Models

Validated measures of pain catastrophizing primarily assess catastrophizing as a stable trait. However, emerging evidence suggests catastrophizing flu...

GEM-GPT Enables Personalized Cell Type-Resolved Therapeutic Design for Systems Pharmacology

Generative artificial intelligence (AI) has emerged as a powerful framework for drug discovery, yet most current approaches follow one-drug-one-gene t...

Spatial machine learning and longitudinal analysis of skilled antenatal care access and fertility-related inequities in Ghana (1988-2022)

This study focuses on the relationship between access to Advanced Neonatal Care (ANC) and fertility across the regions in Ghana between 1988 and 2022....

Causal-Adversarial Probing of Clinical Covariates for Prostate MRI Grading

Deep learning models for prostate MRI-based cancer grading may encode clinical covariates that either reflect useful disease-related signal or non-gen...

Jul 16 2026 2607.14720v1
From Current-Wave to Longitudinal Risk Prediction: A Leakage-Aware Stacked Ensemble Framework for Adolescent Substance Use Using the ABCD Study

Adolescent use of alcohol, nicotine, and marijuana remains a major public health concern in the United States. Early identification of youth at elevat...

Evolution of Accuracy and Visual-Cognitive Errors in a Decade of Vision-Language AI Models

Vision language models (VLMs) have made remarkable progress in visual reasoning during the last decade. Most evaluations have used simple scenes (MS-C...

Jul 10 2026 2607.09654v1
Opioid- and NMDA-receptor-dependent neural plasticity mediates long-term analgesia from motor cortical stimulation

Exogenous opioids that activate mu-opioid receptors (MORs) in nociceptive circuits mediate transient pain relief lasting minutes to hours but have mor...

Prediction of post-operative delirium with machine learning in abdominal surgery with comorbidity indices and laboratory values

Background: Postoperative delirium (POD) is a complication associated with most types of surgery, and is associated with a number of detrimental effec...

Enhancing Road Safety: An IoT-Based Accident Detection and Prevention Mechanism

Road traffic accidents remain a critical global crisis, consistently serving as a primary driver of preventable mortality and severe injury. These inc...

Jun 21 2026 2606.22381v1
A hierarchical clinical fusion transformer model for personalized opioid treatment: Development and validation in diabetic surgical patients

Background Machine learning (ML) models are increasingly used to predict adverse outcomes after surgery. However, most rely on static patient characte...

Stigmatizing Language Detection in Opioid Use Disorder Patient-Directed Discharge Clinical Documentation: A Privacy-Preserving Analysis Using a Locally Deployed Large Language Model

Objective: Stigmatizing language in the electronic health record (EHR) has been associated with adverse patient experience in substance use disorder c...

Phylogenetically Dispersed Subsetting for Species-Level Machine Learning Evaluation: Dependence-Aware Validation and Limited Effective Information

Machine learning is increasingly applied to species-level biological data, but phylogenetic autocorrelation can make evaluation species statistically ...

Widespread use of invalid statistical tests in biomedical machine learning

Machine learning is accelerating biomedical research. Cross-validation is widely used to compare predictive performance -- not only to benchmark algor...

DynoSys 2.0: Graph-Based Modeling of Dynamic Risk States and System Transitions in Human Behaviours Development

Human behavioral and mental health outcomes arise from interactions among genetic, environmental, and neurobiological systems. Existing frameworks oft...

CAWI: Copula-Aligned Weight Initialization for Randomized Neural Networks

Randomized neural networks (RdNNs) enable efficient, backpropagation-free training by freezing randomly initialized input-to-hidden weights, which per...

May 12 2026 2605.12580v1
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