Allergy & Immunology

Latest AI and machine learning research in allergy & immunology for healthcare professionals.

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AlphaMissense pathogenicity scores predict response to immunotherapy and enhances the predictive capability of tumor mutation burden

Tumor Mutational Burden (TMB) is a widely used biomarker for selecting cancer patients for immune ch...

Multivariate analysis of glycogenes reveals coordinated regulation of immunoglobulin glycosylation in an immortalized human B cell system

While neutralizing ability has traditionally been considered the most important antibody function, a...

RoBep: A Region-Oriented Deep Learning Model for B-Cell Epitope Prediction

Accurate in silico identification of B-cell epitope residues is crucial for antibody design and stru...

Characterizing spatial functional microniches with SpaceTravLR

The advent of spatial omics has revolutionized our understanding of tissue biology; however, these t...

Predictive power of different Akkermansia phylogroups in clinical response to PD-1 blockade against non-small cell lung cancer

Immune checkpoint blockade has emerged as a promising form of cancer therapy. However, only some pat...

H3BERTa: A CDR-H3 specific language model for antibody repertoire analysis

Antibodies are central to immune defense and therapeutic design, yet predicting which sequences conf...

IMMUNIA: A Multi-LLM Reasoning Agent for Immunoregulatory Surfaceome Discovery

Biomarker discovery for immunotherapy often requires reasoning across complex immune contexts. We pr...

From Tasks to Topology: Dorsal and Ventral Streams Emerge in Optimized Neural Networks

The primate visual system is organized into dorsal and ventral pathways, classically linked to visuo...

Targeting peptide–MHC complexes with designed T cell receptors and antibodies

Class I major histocompatibility complexes (MHCs), expressed on the surface of all nucleated cells, ...

Self-supervised AI reveals a lethal discohesive phenotype in lung adenocarcinoma

Applications of artificial intelligence (AI) to histopathology are now common, but most require supe...

A transcription factor-responsive enhancer discovery platform for targeted immunotherapy

Synthetic enhancers with high specificity are crucial for therapeutic gene control. Although existin...

DPCMHC: efficient prediction of MHC-peptide binding affinity by deep learning based on dual-padding convolution

Predicting peptide binding affinities to major histocompatibility complex class I (MHCI) is a crucia...

ROSIE-Enabled Spatial Mapping Reveals Architectural Fragmentation and Immune Reprogramming in Lung Adenocarcinoma Evolution

The progression of lung adenocarcinoma (LUAD) from precancerous lesions to invasive carcinoma entail...

Ensemble-DeepSets: an interpretable deep learning framework for single-cell resolution profiling of immunological aging

Immunological aging (immunosenescence) drives increased susceptibility to infections and reduced vac...

Successful Predictive Modeling of Pollen Fitness Phenotypes Is Enabled by Measures of Expression Specificity

The ability to predict phenotypes from genotypes in multicellular organisms remains limited despite ...

Assessing Inflammatory Protein Biomarkers in COPD Subjects with and without Alpha-1 Antitrypsin Deficiency

Individuals homozygous for the Alpha-1 Antitrypsin (AAT) Z allele (Pi*ZZ) exhibit heterogeneity in C...

MUTATE: A Human Genetic Atlas of Multi-organ AI Endophenotypes using GWAS Summary Statistics

Artificial intelligence (AI) has been increasingly integrated into imaging genetics to provide inter...

Machine learning models predict long COVID outcomes based on baseline clinical and immunologic factors

The post-acute sequelae of SARS-CoV-2 (PASC), also known as long COVID, remain a significant health ...

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