Allergy & Immunology

The association between plasma IgG N-glycosylation and viral encephalitis in children: a hospital-based case-control study.

BACKGROUND: Viral encephalitis (VE) is an acute inflammatory disease caused by viral infection. Children are at a significantly higher risk of developing VE than adults. Immunoglobulin G (IgG) N-glycosylation plays a key role in regulating the balance between anti-inflammatory and pro-inflammatory responses. This study aimed to investigate the profile of IgG N-glycosylation among children with VE....

Heterojunction-Engineered Mass Spectrometry Platform for Deciphering Serum Metabolic Fingerprints in Diagnosis of Respiratory Diseases.

Respiratory diseases, including bronchial asthma (BA), chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), and lung cancer (LCa), pose a major global health challenge due to overlapping symptoms that frequently delay accurate diagnosis. Although metabolomics-based molecular phenotyping offers a promising path forward, its application in clinical treatment is limited by t...

Integrating multi-omics analysis and machine learning to refine molecular subtypes and prognostic assessment of lower-grade glioma.

Lower-grade glioma (LGG) is a highly heterogeneous disease, making accurate prognosis prediction and the development of precise, personalized treatmen...

Recent progress in the effects and mechanisms of non-thermal technologies on alleviating food allergy.

Food allergy is a big concern in food safety. Thermal processing is an effective approach to tackle it, but the method might significantly diminish th...

Identification of RPL4 as a biomarker associated with disulfidptosis and arachidonic acid metabolism in breast cancer.

OBJECTIVE: Disulfidptosis is a recently discovered mechanism of cell death caused by disulfide stress. Arachidonic acid metabolism (AAM) is one of the...

Pancreatic cancer.

Pancreatic ductal adenocarcinoma remains one of the deadliest malignancies, characterized by late diagnosis, aggressive biology and limited therapeuti...

A comparison of two- and three-dose MVA-BN mpox vaccination series on anti-monkeypox virus immunity.

The 2022 global outbreak of clade IIb mpox represented a turning point in public health's handling of poxviruses. The primary vaccine available for th...

Machine learning-based prognostic signature integrating mitochondrial function and programmed cell death patterns in pancreatic adenocarcinoma.

The interplay between mitochondria and programmed cell deaths (PCD) is associated with tumor pathogenesis. However, the specific roles of genes relate...

Integrating single-cell multi-omics and machine learning to reveal triaptosis heterogeneity in clear cell renal cell carcinoma.

Triaptosis, an emerging form of cell death, remains poorly characterized in terms of its heterogeneity within clear cell renal cell carcinoma (ccRCC)....

National Institute of Allergy and Infectious Diseases (NIAID) - Bundeswehr Institute of Radiobiology (BIR) Joint Programmatic Workshop on a Global Approach to Medical Countermeasure Development in Radiological Public Health Preparedness.

This invited commentary grew out of a presentation made at the 2025 ConRad Meeting in Munich, Germany, and summarizes talks made by researchers suppor...

Generation of contrast-enhanced cardiac MRI from contrast-free scans: a multi-center, multi-manufacturer study.

BACKGROUND: Late gadolinium enhancement (LGE) cardiac magnetic resonance imaging (MRI) is regarded as the non-invasive gold standard for myocardial ti...

Non-invasive profiling of the tumour microenvironment with spatial ecotypes.

Multicellular programs in the tumour microenvironment (TME) drive cancer pathogenesis and response to therapy but remain challenging to identify and p...

Design and in silico evaluation of an mRNA vaccine against HTLV-1 using AI-driven reverse vaccinology approaches.

Human T-lymphotropic virus type 1 (HTLV-1) is the first discovered human oncogenic retrovirus that can cause adult T-cell leukemia/lymphoma, HTLV-1-as...

Global Trends in Postoperative Sepsis After Pancreatoduodenectomy: A Bibliometric Analysis.

INTRODUCTION: Postoperative sepsis after pancreatoduodenectomy (PSPD) remains a major determinant of morbidity and mortality. Although extensive clini...

Controlled human malaria infection in adults identify combinations of merozoite antigens associated with clinical immunity.

Two vaccines are currently licensed against Plasmodium falciparum malaria but offer only partial protection that wanes, necessitating repeated dosing ...

Homogeneous image-based digital immunoassays with high error tolerance.

There is a significant global health need to translate more in vitro diagnostic tests from clinical laboratories to field-based applications, includin...

Classifying and visualizing medication use in the ABCD study.

Medication use during adolescence provides important insight into current health and treatment patterns. However, these data are often difficult to an...

Engineered artificial antigen-presenting cells for tumor immunotherapy: Design strategies, clinical applications, and translational challenges.

Immunotherapy has long played a pivotal role in cancer treatment, and antigen-presenting cell (APC)-based immunotherapy represents a promising strateg...

Synthetic inducible bacteria normalize the microenvironment of refractory tumors, potentiating checkpoint inhibitor responses.

Immunotherapy has transformed cancer treatment but remains ineffective in many solid tumors, largely due to the immunosuppressive tumor microenvironme...

Overexpression of NMNAT3 suppresses melanoma progression by reprogramming NAD⁺ metabolism.

BACKGROUND: Melanoma represents a highly aggressive and metastatic form of malignant skin cancer. that remains challenging to treat clinically. Tumor ...